Pathway Details

 Recommended name Folate biosynthesis
 Alternative names
 Reactions
NADH + H+ + 6,7-Dihydrobiopterin <-> NAD+ + Tetrahydrobiopterin
2 NADP+ + 5,6,7,8-Tetrahydrofolate <-> 2 H+ + 2 NADPH + Folate
L-Glutamine + Chorismate <-> L-Glutamate + 4-Amino-4-deoxychorismate
5,10-Methylenetetrahydrofolate + dUMP <-> dTMP + Dihydrofolate
H+ + NADPH + Quinonoid 6,7-dimethyl dihydropterin <-> NADP+ + 6,7-Dimethyl tetrahydropterin
H2O + 5,10-Methenyltetrahydromethanopterin <-> 5-Formyl-5,6,7,8-tetrahydromethanopterin
NADH + H+ + Quinonoid 6,7-dimethyl dihydropterin <-> NAD+ + 6,7-Dimethyl tetrahydropterin
Tetrahydrofolyl-[Glu](n) <-> 5,6,7,8-Tetrahydrofolate + Poly-L-glutamate
7,8-Dihydroneopterin <-> Glycolaldehyde + 2-Amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine
n-1 ATP + n-1 L-Glutamate + 10-Formyltetrahydrofolyl L-glutamate <-> n-1 ADP + n-1 Phosphate + 10-Formyltetrahydrofolylpolyglutamate
N-(7-Mercaptoheptanoyl)threonine O3-phosphate + 2-(Methylthio)ethanesulfonate <-> Methane + Coenzyme M 7-mercaptoheptanoylthreonine-phosphate heterodisulfide
Coenzyme M 7-mercaptoheptanoylthreonine-phosphate heterodisulfide + Dihydromethanophenazine <-> N-(7-Mercaptoheptanoyl)threonine O3-phosphate + 2-Mercaptoethanesulfonate + Methanophenazine
NAD+ + 5,6,7,8-Tetrahydrofolate <-> NADH + H+ + Dihydrofolate
ATP + 2-Amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine <-> AMP + 2-Amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate
ATP + L-Glutamate + 10-Formyltetrahydrofolate <-> ADP + Phosphate + 10-Formyltetrahydrofolyl L-glutamate
H2O + Formamidopyrimidine nucleoside triphosphate <-> Formate + 2,5-Diaminopyrimidine nucleoside triphosphate
H+ + NADPH + 2-Amino-4-hydroxy-6,7-dimethyldihydropteridine <-> NADP+ + 2-Amino-4-hydroxy-6,7-dimethyltetrahydropteridine
H2O + 7,8-Dihydroneopterin 3'-triphosphate <-> 2,5-Diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)- amino-4-oxopyrimidine
3 H2O + 7,8-Dihydroneopterin 3'-triphosphate <-> 3 Phosphate + 7,8-Dihydroneopterin
Acceptor + 7,8-Dihydroneopterin <-> Reduced acceptor + Neopterin
2,5-Diaminopyrimidine nucleoside triphosphate <-> 2,5-Diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)- amino-4-oxopyrimidine
NADP+ + 5,6,7,8-Tetrahydromethanopterin <-> H+ + NADPH + 7,8-Dihydromethanopterin
ATP + L-Glutamate + Tetrahydrofolyl-[Glu](n) <-> ADP + Phosphate + Tetrahydrofolyl-[Glu](n)
H+ + NADPH + 7,8-Dihydrobiopterin <-> NADP+ + Tetrahydrobiopterin
Coenzyme F420 + Hydrogen <-> Reduced coenzyme F420
2-Mercaptoethanesulfonate + 5-Methyl-5,6,7,8-tetrahydromethanopterin <-> 5,6,7,8-Tetrahydromethanopterin + 2-(Methylthio)ethanesulfonate
Phosphate + 7,8-Dihydroneopterin <-> H2O + Dihydroneopterin phosphate
7,8-Dihydroneopterin 3'-triphosphate <-> Triphosphate + 6-Pyruvoyltetrahydropterin
NADH + H+ + Quinonoid 7,8-dihydropterin <-> NAD+ + Tetrahydropterin
H2O + 7,8-Dihydroneopterin 3'-triphosphate <-> Diphosphate + Dihydroneopterin phosphate
Reduced coenzyme F420 + 5,10-Methylenetetrahydromethanopterin <-> Coenzyme F420 + 5-Methyl-5,6,7,8-tetrahydromethanopterin
ATP + Formate + 5,6,7,8-Tetrahydrofolate <-> ADP + Phosphate + 10-Formyltetrahydrofolate
NADH + H+ + 2-Amino-4-hydroxy-6,7-dimethyldihydropteridine <-> NAD+ + 2-Amino-4-hydroxy-6,7-dimethyltetrahydropteridine
H+ + NADPH + 6,7-Dihydrobiopterin <-> NADP+ + Tetrahydrobiopterin
NH3 + Chorismate <-> H2O + 4-Amino-4-deoxychorismate
2 NADP+ + Tetrahydrobiopterin <-> 2 H+ + 2 NADPH + Biopterin
H2O + Acceptor + Formylmethanofuran <-> CO2 + Reduced acceptor + Methanofuran
4-Amino-4-deoxychorismate <-> Pyruvate + 4-Aminobenzoate
2 S-Adenosyl-L-methionine + 2,5-Diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)- amino-4-oxopyrimidine <-> H2O + 2 S-Adenosyl-L-homocysteine + 6-(3'-Triphosphoryl-1'-methylglyceryl)-7-methyl-7,8-dihydrobiopterin
NADP+ + Tetrahydrobiopterin <-> H+ + NADPH + 6-Lactoyl-5,6,7,8-tetrahydropterin
H2O + 7,8-Dihydroneopterin 3'-triphosphate <-> Triphosphate + 6-Pyruvoyltetrahydropterin
Coenzyme F420 + 5,10-Methylenetetrahydromethanopterin <-> Reduced coenzyme F420 + 5,10-Methenyltetrahydromethanopterin
NADP+ + 5,6,7,8-Tetrahydrofolate <-> H+ + NADPH + Dihydrofolate
2 H2O + 7,8-Dihydroneopterin 3'-triphosphate <-> 2 Phosphate + Molybdopterin
Formate + Formamidopyrimidine nucleoside triphosphate <-> 2,5-Diaminopyrimidine nucleoside triphosphate
NADP+ + Dihydrofolate <-> H+ + NADPH + Folate
NAD+ + 5,6,7,8-Tetrahydrofolate <-> NADH + H+ + Folate
4-Aminobenzoate + 2-Amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine <-> H2O + Dihydropteroate
NADP+ + 6-Lactoyl-5,6,7,8-tetrahydropterin <-> H+ + NADPH + 6-Pyruvoyltetrahydropterin
ATP + L-Glutamate + Dihydropteroate <-> ADP + Phosphate + Dihydrofolate
NAD+ + Dihydrofolate <-> NADH + H+ + Folate
Formylmethanofuran + 5,6,7,8-Tetrahydromethanopterin <-> Methanofuran + 5-Formyl-5,6,7,8-tetrahydromethanopterin
H2O + GTP <-> Formamidopyrimidine nucleoside triphosphate
2-Amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-Aminobenzoate <-> Diphosphate + Dihydropteroate
ATP + L-Glutamate + 5,6,7,8-Tetrahydrofolate <-> ADP + Phosphate + Tetrahydrofolyl-[Glu](2)
H+ + NADPH + Quinonoid 7,8-dihydropterin <-> NADP+ + Tetrahydropterin
 Classification
Metabolism of Cofactors and Vitamins
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