Reaction Details
Reaction ID
2021
Stochiometric Equation
Coenzyme A + 3-Hydroxy-3-methylglutaryl-CoA <-> H2O + Acetyl-CoA + Acetoacetyl-CoA
Substrates
Coenzyme A
3-Hydroxy-3-methylglutaryl-CoA
Products
H2O
Acetyl-CoA
Acetoacetyl-CoA
Enzymes known to
catalyse this reaction
(curated information)
EC Number
in Organism
UniProtKB Link
PubMedID
2.3.3.10
Enterococcus faecalis
UniProtKB
12107122
2.3.3.10
Enterococcus faecalis
UniProtKB
17128980
2.3.3.10
Gallus gallus
UniProtKB
11087424
2.3.3.10
Gallus gallus
UniProtKB
12743118
2.3.3.10
Gallus gallus
UniProtKB
15247244
2.3.3.10
Gallus gallus
UniProtKB
8755743
2.3.3.10
Mus musculus
UniProtKB
24315375
Pathways
Biosynthesis of secondary metabolites
Butanoate metabolism
Metabolic pathways
Synthesis and degradation of ketone bodies
Terpenoid backbone biosynthesis
Valine, leucine and isoleucine degradation
External Links
KEGG-Pathway-ID
map01110
map00650
map01100
map00072
map00900
map00280
KEGG-Reaction-ID
R01978
MetaNetX-Reaction-ID
MNXR145223
View all entries for reaction Coenzyme A + 3-Hydroxy-3-methylglutaryl-CoA <-> H2O + Acetyl-CoA + Acetoacetyl-CoA
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