Reaction Details

Reaction ID

1788

Stochiometric Equation

NAD+ + Coenzyme A + 4-Methyl-2-oxopentanoate <-> NADH + H+ + CO2 + 3-Methylbutanoyl-CoA

Substrates

Coenzyme A

NAD+

4-Methyl-2-oxopentanoate

Products

CO2

NADH

3-Methylbutanoyl-CoA

H+

Enzymes known to
catalyse this reaction
(curated information)

EC Number	in Organism	UniProtKB Link	PubMedID
1.2.4.4	Rattus norvegicus	UniProtKB	8537366
Complex: 1.2.4.4 / 2.3.1.168	Bos taurus	UniProtKB	283398
Complex: 1.2.4.4 / 2.3.1.168	Oryctolagus cuniculus	UniProtKB	7142221
Complex: 1.2.4.4 / 2.3.1.168	Rattus norvegicus	UniProtKB	658436
Complex: 1.2.4.4 / 2.3.1.168 / 1.8.1.4	Homo sapiens	UniProtKB	3593587
Complex: 1.2.4.4 / 2.3.1.168 / 1.8.1.4	Rattus norvegicus	UniProtKB	3571202

Pathways

Valine, leucine and isoleucine degradation

External Links

KEGG-Pathway-ID

map00280

KEGG-Reaction-ID

R01651

MetaNetX-Reaction-ID

MNXR102172

Rhea-Reaction-ID

25177 25178 25180 25179

MetaCyc-Reaction-ID

2KETO-4METHYL-PENTANOATE-DEHYDROG-RXN