Enzyme Details

 EC Classification 1.2.4.1
 Enzyme name
(recommended)		 pyruvate dehydrogenase (acetyl-transferring)
 Alternative names pyruvate:[dihydrolipoyllysine-residue acetyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-acetylating)
MtPDC (mitochondrial pyruvate dehydogenase complex)
pyruvate decarboxylase
pyruvate dehydrogenase
pyruvate dehydrogenase (lipoamide)
pyruvate dehydrogenase complex
pyruvate:lipoamide 2-oxidoreductase (decarboxylating and acceptor-acetylating)
pyruvic acid dehydrogenase
pyruvic dehydrogenase
 Classification
Oxidoreductases
Acting on the aldehyde or oxo group of donors
With a disulfide as acceptor
 Catalyses reactions
Pyruvate + Lipoamide <-> CO2 + S-Acetyldihydrolipoamide
Pyruvate + NAD+ + Coenzyme A <-> NADH + H+ + CO2 + Acetyl-CoA
Lipoamide + 2-(alpha-Hydroxyethyl)thiamine diphosphate <-> Thiamine diphosphate + S-Acetyldihydrolipoamide
CO2 + 2-(alpha-Hydroxyethyl)thiamine diphosphate <-> Pyruvate + Thiamine diphosphate
Pyruvate + 2,6-Dichloroindophenol <-> CO2 + Acetaldehyde + Reduced 2,6-dichlorophenolindophenol
Thiamine 2-thiazolone diphosphate + PDHc E1 <-> Enzyme-inhibitor complex
PDHc E1 + Thiamine 2-thiothiazolone pyrophosphate <-> Enzyme-inhibitor complex
Thiamine diphosphate + PDHc E1 <-> Enzyme-ligand complex
Pyruvate + H2O + 2 Hexacyanoferrate(III) <-> 2 H+ + CO2 + Acetate + 2 Hexacyanoferrate(II)
H2O + 2-Oxobutyrate + 2 Hexacyanoferrate(III) <-> 2 H+ + CO2 + Propanoate + 2 Hexacyanoferrate(II)
H2O + 4-Methyl-2-oxopentanoate + 2 Hexacyanoferrate(III) <-> 2 H+ + CO2 + 2 Hexacyanoferrate(II) + Isovaleric acid
 External links Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop


View all entries for EC Class: 1.2.4.1



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