Enzyme Details

EC Classification

1.2.4.4

Enzyme name
(recommended)

3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)

Alternative names

3-methyl-2-oxobutanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating)
2-oxoisocaproate dehydrogenase
2-oxoisovalerate (lipoate) dehydrogenase
3-methyl-2-oxobutanoate dehydrogenase (lipoamide)
3-methyl-2-oxobutanoate:lipoamide oxidoreductase (decarboxylating and acceptor-2-methylpropanoylating)
alpha-keto-alpha-methylvalerate dehydrogenase
alpha-ketoisocaproate dehydrogenase
alpha-ketoisocaproic dehydrogenase
alpha-ketoisocaproic-alpha-keto-alpha-methylvaleric dehydrogenase
alpha-ketoisovalerate dehydrogenase
alpha-oxoisocaproate dehydrogenase
BCKDH
BCOAD
branched chain keto acid dehydrogenase
branched-chain (-2-oxoacid) dehydrogenase (BCD)
branched-chain 2-keto acid dehydrogenase
branched-chain 2-oxo acid dehydrogenase
branched-chain alpha-keto acid dehydrogenase
branched-chain alpha-oxo acid dehydrogenase
branched-chain keto acid dehydrogenase
branched-chain ketoacid dehydrogenase
dehydrogenase, 2-oxoisovalerate (lipoate)
dehydrogenase, branched chain alpha-keto acid

Classification

Oxidoreductases

Acting on the aldehyde or oxo group of donors

With a disulfide as acceptor

Catalyses reactions

NAD+ + Coenzyme A + alpha-Ketovaline <-> NADH + H+ + CO2 + 2-Methylpropanoyl-CoA

Lipoamide + alpha-Ketovaline <-> CO2 + S-(2-Methylpropanoyl)-dihydrolipoamide

Lipoamide + 4-Methyl-2-oxopentanoate <-> CO2 + S-(3-Methylbutanoyl)-dihydrolipoamide

Lipoamide + 3-Methyl-2-oxopentanoate <-> CO2 + S-(2-Methylbutanoyl)-dihydrolipoamide

H2O + alpha-Ketovaline + Acceptor <-> H+ + CO2 + Isobutanoate + Reduced acceptor

NAD+ + Coenzyme A + 4-Methyl-2-oxopentanoate <-> NADH + H+ + CO2 + 3-Methylbutanoyl-CoA

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 1.2.4.4