Web Services provide customizable access to SABIO-RK in a language independent fashion. To use them programmatically, developers can create their own client application to automate the access to the database directly from their simulation software, tools or databases. SABIO-RK can be automatically accessed via RESTful Web Services which are using a Representational State Transfer approach and are designed with speed and ease of use in mind. The Web Services allow the direct SABIO-RK data access by other tools or systems biology modelling platforms. The output of this Web Services search is available in different formats (e.g. SBML, XML).