Enzyme Details

EC Classification

3.2.1.18

Enzyme name
(recommended)

exo-alpha-sialidase

Alternative names

neuraminidase
acetylneuraminyl hydrolase
sialidase
alpha-neuraminidase
acetylneuraminidase

Classification

Hydrolases

Glycosidases

Hydrolysing O-glycosyl compounds

Catalyses reactions

N-Acetylneuraminate + beta-D-Galactosyl-1,4-beta-D-glucosylceramide <-> H2O + GM3

N-Acetylneuraminate + Galactosylceramide <-> H2O + N-Acetylneuraminyl-galactosylceramide

H2O + N-Acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide <-> N-Acetylneuraminate + GA2

N-Acetylneuraminate + D-Galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide <-> H2O + N-Acetylneuraminyl-D-galactosyl-N-acetyl-D-galactosaminyl-(N- acetylneuraminyl)-D-galactosyl-D-glucosylceramide

N-Acetylneuraminate + GT1b <-> H2O + GQ1

H2O + GT1b <-> N-Acetylneuraminate + GD1b

H2O + 2'-(4-Methylumbelliferyl)-alpha-D-N-acetylneuraminic acid <-> N-Acetylneuraminate + 4-Methylumbelliferone

H2O + Mucin <-> N-Acetylneuraminate + Mucin

Lactitol + 3'-Sialyllactose <-> Lactose + Sialyllactitol

3'-Sialyllactose + Lactobionic acid <-> Lactose + Sialyllactobionic acid

N-Acetyllactosamine + 3'-Sialyllactose <-> Lactose + Sialyl-N-acetyllactosamine

3'-Sialyllactose + 3-O-beta-D-Galactopyranosyl-D-arabinitol <-> Lactose + Sialyl-3-O-beta-D-galactopyranosyl-D-arabinitol

Lactose + Sialyl-alpha-(2,3)-lactose <-> Lactose + Sialyllactose

H2O + Sialyllactose <-> Lactose + N-Acetylneuraminate

H2O + Sialyl-alpha-(2,3)-lactose <-> Lactose + N-Acetylneuraminate

H2O + Sialyl-alpha-(2,6)-lactose <-> Lactose + N-Acetylneuraminate

H2O + Sialyl-alpha-(2,3)-lactose <-> Lactose + 2,7-Anhydro-alpha-N-acetylneuraminic acid

H2O + Sialyl-alpha-(2,6)-lactose <-> Lactose + 2,7-Anhydro-alpha-N-acetylneuraminic acid

H2O + Sialyl-alpha-(2,3)-lactose <-> Lactose + 2-Deoxy-2,3-dehydro-N-acetylneuraminic acid

H2O + 4-Cyanophenyl-alpha-D-N-acetylneuraminic acid <-> N-Acetylneuraminate + 4-Cyanophenol

H2O + 3-Nitrophenyl-alpha-D-N-acetylneuraminic acid <-> N-Acetylneuraminate + 3-Nitrophenol

H2O + 3-Chlorophenyl-alpha-D-N-acetylneuraminic acid <-> N-Acetylneuraminate + 3-Chlorophenol

H2O + Phenyl-alpha-D-N-acetylneuraminic acid <-> Phenol + N-Acetylneuraminate

H2O + 4-Methylumbelliferyl alpha-D-sialosyl-(2->3)-beta-D-galactopyranoside <-> N-Acetylneuraminate + 3'-(4-Methylumbelliferyl beta-D-galactoside)

H2O + p-Nitrophenyl-alpha-D-N-acetylneuraminic acid <-> N-Acetylneuraminate + p-Nitrophenol

H2O + 1,2-Dioxetane sialic acid <-> N-Acetylneuraminate + 1,2-Dioxetane

Lactose + Sialylated fetuin <-> Sialyl-alpha-(2,3)-lactose + Fetuin

4-Methylumbelliferyl-beta-D-galactoside + Sialyl-alpha-(2,3)-lactose <-> Lactose + Sialyl-4-methylumbelliferyl-beta-D-galactoside

H2O + alpha-N-Acetylneuraminyl-2,3-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-beta-D-mannosyl-1,4-N-acetylglucosamin <-> N-Acetylneuraminate + beta-D-Galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-beta-D-mannosyl-1,4-N-acetylglucosamin

H2O + alpha-N-Acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-beta-D-mannosyl-1,4-N-acetylglucosamin <-> N-Acetylneuraminate + beta-D-Galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-beta-D-mannosyl-1,4-N-acetylglucosamin

H2O + GD1b <-> N-Acetylneuraminate + D-Galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide

H2O + (N-Glycolylneuraminyl)-D-galactosyl-D-glucosylceramide <-> beta-D-Galactosyl-1,4-beta-D-glucosylceramide + N-Glycoloyl-neuraminate

H2O + alpha-2-3-Sialosylparagloboside <-> N-Acetylneuraminate + asialo-Sialosylparagloboside

H2O + Fetuin <-> N-Acetylneuraminate + Fetuin

H2O + Transferrin <-> N-Acetylneuraminate + Transferrin

H2O + alpha1-acid Glycoprotein <-> N-Acetylneuraminate + alpha1-acid Glycoprotein

H2O + D-Galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide <-> N-Acetylneuraminate + GA1

H2O + Neu5Ac-DSPE <-> N-Acetylneuraminate + DSPE

H2O + alpha-N-Acetylneuraminyl-2,3-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-D-glucosylceramide <-> N-Acetylneuraminate + Gal-beta1->4GlcNAc-beta1->3Gal-beta1->4Glc-beta1->1'Cer

H2O + Neu5Ac-alpha2->3Gal-beta1->4GlcNAc-beta1->3Gal-beta1->4GlcNAc-beta1->3Gal-beta1->4Glc-beta1->1'Cer <-> N-Acetylneuraminate + Gal-beta1->4GlcNAc-beta1->3Gal-beta1->4GlcNAc-beta1->3Gal-beta1->4Glc-beta1->1'Cer

H2O + Neu5Ac-alpha2->3Gal-beta1->4GlcNAc-beta1->3(Neu5Ac-alpha2->3Gal-beta1->4GlcNAc-beta1->6)Gal-beta1->4GlcNAc-beta1->3Gal-beta1->4Glc-beta1->1'Cer <-> N-Acetylneuraminate + Gal-beta1->4GlcNAc-beta1->3(3Gal-beta1->4GlcNAc-beta1->6)Gal-beta1->4GlcNAc-beta1->3Gal-beta1->4Glc-beta1->1'Cer

H2O + Neu5Ac-alpha2->6Gal-beta1->4GlcNAc-beta1->3Gal-beta1->4Glc-beta1->1'Cer <-> N-Acetylneuraminate + Gal-beta1->4GlcNAc-beta1->3Gal-beta1->4Glc-beta1->1'Cer

H2O + Neu5Gc-alpha2->3Gal-beta1->4GlcNAc-beta1->3Gal-beta1->4Glc-beta1->1'Cer <-> N-Glycoloyl-neuraminate + Gal-beta1->4GlcNAc-beta1->3Gal-beta1->4Glc-beta1->1'Cer

H2O + 2-(3'-Methoxyphenyl)-N-acetyl-alpha-neuraminic acid <-> N-Acetylneuraminate + m-Hydroxyanisole

H2O + N-Glycoloyl-neuraminyl-alpha-(2,3)-lactose <-> Lactose + N-Glycoloyl-neuraminate

H2O + Sialyl-alpha-(2,6)-N-acetylgalactosamine <-> N-Acetylgalactosamine + N-Acetylneuraminate

H2O + N-Glycoloyl-neuraminyl-alpha-(2,6)-N-acetylgalactosamine <-> N-Acetylgalactosamine + N-Glycoloyl-neuraminate

H2O + N-Glycolylneuraminyl-D-galactosyl-D-glucosylceramide <-> beta-D-Galactosyl-1,4-beta-D-glucosylceramide + N-Glycoloyl-neuraminate

H2O + GT1 <-> N-Acetylneuraminate + GD1

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 3.2.1.18