Enzyme Details

 EC Classification 3.1.1.1
 Enzyme name
(recommended)
carboxylesterase
 Alternative names methylbutyrase
carboxylic-ester hydrolase
ali-esterase
B-esterase
monobutyrase
cocaine esterase
procaine esterase
methylbutyrase
vitamin A esterase
butyryl esterase
carboxyesterase
carboxylate esterase
carboxylic esterase
methylbutyrate esterase
triacetin esterase
carboxyl ester hydrolase
butyrate esterase
alpha-carboxylesterase
propionyl esterase
nonspecific carboxylesterase
esterase D
esterase B
esterase A
serine esterase
carboxylic acid esterase
cocaine esterase
 Classification
Hydrolases
Acting on ester bonds
Carboxylic ester hydrolases
 Catalyses reactions
H2O + Carboxylic ester <-> Alcohol + Carboxylate
H2O + All-trans-Retinyl palmitate <-> Palmitate + Retinol
H2O + Cocaine <-> Benzoate + Ecgonine methyl ester
H2O + p-Nitrophenyl caproate <-> Hexanoate + p-Nitrophenol
H2O + p-Nitrophenyl dodecanoate <-> Dodecanoate + p-Nitrophenol
H2O + Valacyclovir <-> L-Valine + Acyclovir
H2O + p-Nitrophenyl acetate <-> Acetate + p-Nitrophenol
H2O + Phenylacetic acid <-> Acetate + Phenol
H2O + p-Nitrophenyl propionate <-> Propanoate + p-Nitrophenol
H2O + 1-Naphthylacetic acid <-> Acetate + alpha-Naphthol
H2O + p-Nitrophenyl butyrate <-> Butanoate + p-Nitrophenol
H2O + (S)-alpha-Cyano(6-methoxy-2-naphthyl)-methyl-(1S)-cis-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylate <-> (1S)-cis-3-(2,2-Dichlorovinyl)-2,2-dimethylcyclopropane carboxylate + (S)-alpha-Cyano(6-methoxy-2-naphthyl)-methanol
H2O + alpha-Cyano-(6-methoxy-2-naphthyl)-methyl-2,2,3,3-tetramethylcyclopropane-1-carboxylate <-> alpha-Cyano-(6-methoxy-2-naphthyl)-methanol + 1-Carboxy-2,2,3,3-tetramethylcyclopropane
H2O + alpha-Cyano-(6-methoxy-2-naphthyl)-methyl-3-(2,2-dimethylvinyl)-2,2-dimethylcyclopropane carboxylate <-> alpha-Cyano-(6-methoxy-2-naphthyl)-methanol + 3-(2,2-Dimethylvinyl)-2,2-dimethylcyclopropane carboxylate
H2O + (R)-alpha-Cyano(6-methoxy-2-naphthyl)-methyl-(1R)-trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylate <-> (1R)-trans-3-(2,2-Dichlorovinyl)-2,2-dimethylcyclopropane carboxylate + (R)-alpha-Cyano(6-methoxy-2-naphthyl)-methanol
H2O + (S)-alpha-Cyano(6-methoxy-2-naphthyl)-methyl-(1R)-trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylate <-> (1R)-trans-3-(2,2-Dichlorovinyl)-2,2-dimethylcyclopropane carboxylate + (S)-alpha-Cyano(6-methoxy-2-naphthyl)-methanol
H2O + (R)-alpha-Cyano(6-methoxy-2-naphthyl)-methyl-(2R)-2-(4-chlorophenyl)-3-methyl butanoate <-> (R)-alpha-Cyano(6-methoxy-2-naphthyl)-methanol + (2R)-2-(4-Chlorophenyl)-3-methyl butanoate
H2O + (R)-alpha-Cyano(6-methoxy-2-naphthyl)-methyl-(1S)-trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylate <-> (1S)-trans-3-(2,2-Dichlorovinyl)-2,2-dimethylcyclopropane carboxylate + (R)-alpha-Cyano(6-methoxy-2-naphthyl)-methanol
H2O + Cypermethrin <-> 3-(2,2-Dichlorovinyl)-2,2-dimethylcyclopropane carboxylate + alpha-Cyano(3-phenoxyphenyl)methanol
H2O + (S)-alpha-Cyano(6-methoxy-2-naphthyl)-methyl-(1S)-trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylate <-> (1S)-trans-3-(2,2-Dichlorovinyl)-2,2-dimethylcyclopropane carboxylate + (S)-alpha-Cyano(6-methoxy-2-naphthyl)-methanol
H2O + (S)-alpha-Cyano(6-methoxy-2-naphthyl)-methyl-(2R)-2-(4-chlorophenyl)-3-methyl butanoate <-> (2R)-2-(4-Chlorophenyl)-3-methyl butanoate + (S)-alpha-Cyano(6-methoxy-2-naphthyl)-methanol
H2O + (S)-alpha-Cyano(6-methoxy-2-naphthyl)-methyl-(2S)-2-(4-chlorophenyl)-3-methyl butanoate <-> (S)-alpha-Cyano(6-methoxy-2-naphthyl)-methanol + (2S)-2-(4-Chlorophenyl)-3-methyl butanoate
H2O + (S)-alpha-Cyano(6-methoxy-2-naphthyl)-methyl-(1R)-cis-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylate <-> (1R)-cis-3-(2,2-Dichlorovinyl)-2,2-dimethylcyclopropane carboxylate + (S)-alpha-Cyano(6-methoxy-2-naphthyl)-methanol
H2O + (R)-alpha-Cyano(6-methoxy-2-naphthyl)-methyl-(1S)-cis-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylate <-> (1S)-cis-3-(2,2-Dichlorovinyl)-2,2-dimethylcyclopropane carboxylate + (R)-alpha-Cyano(6-methoxy-2-naphthyl)-methanol
H2O + (R)-alpha-Cyano(6-methoxy-2-naphthyl)-methyl-(1R)-cis-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylate <-> (R)-alpha-Cyano(6-methoxy-2-naphthyl)-methanol + (1R)-cis-3-(2,2-Dichlorovinyl)-2,2-dimethylcyclopropane carboxylate
H2O + cis-Permethrin <-> 3-Phenoxybenzyl alcohol + cis-Dichlorochrysanthemic acid
H2O + 1-RS-trans-Permethrin <-> 3-Phenoxybenzyl alcohol + 1-R,S-trans-Dichlorochrysanthemic acid
H2O + Resmethrin <-> Methylchrysanthemic acid + 5-Benzyl-3-furylmethyl alcohol
H2O + trans-Permethrin <-> 3-Phenoxybenzyl alcohol + trans-Dichlorochrysanthemic acid
H2O + 1-R,S-cis-Permethrin <-> 1-R,S-cis-Dichlorochrysanthemic acid + 3-Phenoxybenzyl alcohol
H2O + alpha-Cypermethrin <-> alpha-R,S-Cyano-(3-phenoxyphenyl)methyl alcohol + cis-Dichlorochrysanthemic acid
H2O + p-Nitrophenyl valerate <-> Pentanoate + p-Nitrophenol
H2O + Cholesteryl oleate <-> Cholesterol + Oleate
H2O + Trioleoylglycerol <-> Oleate + sn-1,2-Dioleoylglycerol
H2O + Ethyl hexanoate <-> Ethanol + Hexanoate
H2O + Ethyl pentanoate <-> Ethanol + Pentanoate
H2O + p-Nitrophenyl octanoate <-> Octanoate + p-Nitrophenol
H2O + p-Nitrophenyl decanoate <-> Decanoate + p-Nitrophenol
H2O + Ethyl propionate <-> Ethanol + Propanoate
H2O + Ethyl butanoate <-> Ethanol + Butanoate
H2O + Phenylthioacetate <-> Phenol + Thioacetate
H2O + Hexanoyl acetate <-> Acetate + Hexanol
H2O + Butyl acetate <-> Acetate + Butanol
H2O + Propyl acetate <-> Acetate + 1-Propanol
H2O + Acetic ester <-> Ethanol + Acetate
H2O + 1-Naphthylbutanoic acid <-> Butanoate + alpha-Naphthol
H2O + p-Nitrophenyl hexadecanoate <-> Palmitate + p-Nitrophenol
H2O + p-Nitrophenyl tetradecanoate <-> Myristic acid + p-Nitrophenol
H2O + Deltamethrin <-> Cyanide + 3-Phenoxybenzaldehyde + cis-Dibromochrysanthemic acid
H2O + Esfenvalerate <-> Cyanide + cis-Dichlorochrysanthemic acid + 3-Phenoxybenzaldehyde
H2O + Benzocaine <-> Ethanol + 4-Aminobenzoate
H2O + Propyl 4-aminobenzoate <-> 4-Aminobenzoate + 1-Propanol
H2O + Butyl 4-aminobenzoate <-> 4-Aminobenzoate + Butanol
H2O + p-Nitrophenyl laurate <-> Dodecanoate + p-Nitrophenol
H2O + Oseltamivir <-> Unknown + Oseltamivir carboxylate
H2O + L-Methylphenidate <-> Methanol + Ritalinic acid
H2O + D-Methylphenidate <-> Methanol + Ritalinic acid
H2O + o-Nitrophenyl acetate <-> Acetate + o-Nitrophenol
H2O + 5'-L-Phenylalanyl-floxuridine <-> L-Phenylalanine + 5-Fluorodeoxyuridine
H2O + 5'-D-Phenylalanyl-floxuridine <-> D-Phenylalanine + 5-Fluorodeoxyuridine
H2O + 3'-D-Phenylalanyl-floxuridine <-> D-Phenylalanine + 5-Fluorodeoxyuridine
H2O + 3'-L-Phenylalanyl-floxuridine <-> L-Phenylalanine + 5-Fluorodeoxyuridine
H2O + 5'-L-Prolyl-floxuridine <-> L-Proline + 5-Fluorodeoxyuridine
H2O + 3'-L-Prolyl-floxuridine <-> L-Proline + 5-Fluorodeoxyuridine
H2O + 5'-L-Leucyl-floxuridine <-> L-Leucine + 5-Fluorodeoxyuridine
H2O + 3'-L-Leucyl-floxuridine <-> L-Leucine + 5-Fluorodeoxyuridine
H2O + 3'-L-Lysyl-floxuridine <-> L-Lysine + 5-Fluorodeoxyuridine
H2O + 5'-L-Lysyl-floxuridine <-> L-Lysine + 5-Fluorodeoxyuridine
H2O + 3'-L-Isoleucyl-floxuridine <-> L-Isoleucine + 5-Fluorodeoxyuridine
H2O + 3'-L-Aspartyl-floxuridine <-> L-Aspartate + 5-Fluorodeoxyuridine
H2O + 5'-L-Aspartyl-floxuridine <-> L-Aspartate + 5-Fluorodeoxyuridine
H2O + 5'-D-Valyl-floxuridine <-> D-Valine + 5-Fluorodeoxyuridine
H2O + 5'-L-Valyl-floxuridine <-> L-Valine + 5-Fluorodeoxyuridine
H2O + 3'-L-Valyl-floxuridine <-> L-Valine + 5-Fluorodeoxyuridine
H2O + 3'-D-Valyl-floxuridine <-> D-Valine + 5-Fluorodeoxyuridine
H2O + 5'-L-Isoleucyl-floxuridine <-> L-Isoleucine + 5-Fluorodeoxyuridine
H2O + 3'-L-Phenylalanyl-gemcitabine <-> L-Phenylalanine + Gemcitabine
H2O + 3'-D-Phenylalanyl-gemcitabine <-> D-Phenylalanine + Gemcitabine
H2O + 5'-L-Phenylalanyl-gemcitabine <-> L-Phenylalanine + Gemcitabine
H2O + 5'-D-Phenylalanyl-gemcitabine <-> D-Phenylalanine + Gemcitabine
H2O + 3'-L-Valyl-gemcitabine <-> L-Valine + Gemcitabine
H2O + 3'-L-Isoleucyl-gemcitabine <-> L-Isoleucine + Gemcitabine
H2O + 3'-D-Valyl-gemcitabine <-> D-Valine + Gemcitabine
H2O + 5'-L-Isoleucyl-gemcitabine <-> L-Isoleucine + Gemcitabine
H2O + 5'-D-Valyl-gemcitabine <-> D-Valine + Gemcitabine
H2O + 5'-L-Valyl-gemcitabine <-> L-Valine + Gemcitabine
H2O + 5'-L-Phenylalanyl-2-bromo-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazole <-> L-Phenylalanine + 2-Bromo-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazole
H2O + 5'-D-Phenylalanyl-2-bromo-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazole <-> D-Phenylalanine + 2-Bromo-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazole
H2O + L-Phenylalanine ethyl ester <-> Ethanol + L-Phenylalanine
H2O + L-Phenylalanine benzyl ester <-> L-Phenylalanine + Benzol
H2O + N-Acetyl-L-phenylalanine ethyl ester <-> Ethanol + N-Acetyl-L-phenylalanine
H2O + Irinotecan <-> SN-38 + 1,4'-Bipiperidine-1'-carboxylic acid
H2O + 5'-Cinnamic acid-floxuridin <-> Cinnamic acid + 5-Fluorodeoxyuridine
H2O + 3-Methylbutanol-cysteinylglycine <-> Glycine + Felinine
H2O + Nafamostat <-> p-Guanidinobenzoic acid + 6-Amidino-2-naphthol
H2O + Capecitabine <-> Unknown + 5'-Deoxy-5-fluorocytidine
H2O + 4-Methylumbelliferyl acetate <-> Acetate + 4-Methylumbelliferone
H2O + 4-Methylumbelliferyl butyrate <-> Butanoate + 4-Methylumbelliferone
H2O + 4-Methylumbelliferyl heptanoate <-> 4-Methylumbelliferone + Heptanoate
H2O + 4-Methylumbelliferyl octanoate <-> Octanoate + 4-Methylumbelliferone
H2O + 4-Methylumbelliferyl laurate <-> Dodecanoate + 4-Methylumbelliferone
H2O + 4-Methylumbelliferyl palmitate <-> Palmitate + 4-Methylumbelliferone
H2O + 7-Ethyl-10-[4-(1-piperidino)-1-amino]-carbonyloxycamptothecin <-> SN-38 + 4-Amino-1-piperidinecarboxylic acid
H2O + 7-Ethyl-10-[4-N-(5-aminopentanoic acid)-1-piperidino] carbonyloxycamptothecin <-> SN-38 + 4-((4-Carboxybutyl)amino)piperidine-1-carboxylic acid
H2O + Triacetin <-> Acetate + Diacetin
H2O + Tripropionin <-> Propanoate + Glycerol dipropionate
H2O + Tributyrin <-> Butanoate + Dibutyrylglycerol
H2O + Tricaprilin <-> Octanoate + Dioctanoylglycerol
H2O + Trioleoylglycerol <-> Oleate + Dioleoylglycerol
H2O + Vinylacetate <-> Acetate + Polyvinyl alcohol
H2O + Vinyl propionate <-> Propanoate + Polyvinyl alcohol
H2O + Vinyl butyrate <-> Butanoate + Polyvinyl alcohol
H2O + Vinyl laurate <-> Dodecanoate + Polyvinyl alcohol
H2O + Palmityl oleate <-> Oleate + 1-Hexadecanol
 External links Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
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