Enzyme Details

 EC Classification 2.1.1.45
 Enzyme name
(recommended)
thymidylate synthase
 Alternative names 5,10-methylenetetrahydrofolate:dUMP C-methyltransferase
dTMP synthase
thymidylate synthetase
methylenetetrahydrofolate:dUMP C-methyltransferase
TMP synthetase
 Classification
Transferases
Transferring one-carbon groups
Methyltransferases
 Catalyses reactions
5,10-Methylenetetrahydrofolate + dUMP <-> dTMP + Dihydrofolate
ATP + L-Glutamate + Dihydropteroate <-> ADP + Phosphate + Dihydrofolate
2-Mercaptoethanol + E-5-(2-Bromovinyl)-2'-deoxyuridine monophosphate <-> 1-(3-Hydroxy-4-hydroxymethyl-cyclopentyl)-5-[1,4]oxathian-2-yl-1H-pyrimidine-2,4-dione
1,4-Dithiothreitol + 5-Bromo-dUMP <-> dUMP + Oxidized dithiothreitol + Hydrobromic acid
dCMP + 5,10-Methylenetetrahydrofolate <-> Dihydrofolate + 5-Methyldeoxycytidine 5'-phosphate
2 2-Mercaptoethanol + 5-Bromo-dUMP <-> Br- + dUMP + Hydroxyethyl disulfide
 External links Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop


View all entries for EC Class: 2.1.1.45



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