Enzyme Details

 EC Classification 1.8.4.2
 Enzyme name
(recommended)		 protein-disulfide reductase (glutathione)
 Alternative names glutathione:protein-disulfide oxidoreductase
glutathione-insulin transhydrogenase
insulin reductase
reductase, protein disulfide (glutathione)
protein disulfide transhydrogenase
glutathione-protein disulfide oxidoreductase
protein disulfide reductase (glutathione)
GSH-insulin transhydrogenase
protein-disulfide interchange enzyme
protein-disulfide isomerase/oxidoreductase
thiol:protein-disulfide oxidoreductase
thiol-protein disulphide oxidoreductase
 Classification
Oxidoreductases
Acting on a sulfur group of donors
With a disulfide as acceptor
 Catalyses reactions
2 Reduced glutathione + Insulin <-> Oxidized glutathione + Insulin dithiol
Oxidized glutathione + Protein dithiol <-> 2 Reduced glutathione + Protein disulfide
Reduced glutathione + Glutathionylated RNase A <-> Oxidized glutathione + RNase A
Reduced glutathione + Glutathionylated bovine serum albumin <-> Oxidized glutathione + Bovine serum albumin
Reduced glutathione + Glutathionylated 2-mercaptoethanol <-> Oxidized glutathione + 2-Mercaptoethanol
2 Reduced glutathione + Hydroxyethyl disulfide <-> Oxidized glutathione + 2 2-Mercaptoethanol
H+ + NADPH + Hydroxyethyl disulfide <-> NADP+ + 2 2-Mercaptoethanol
NADP+ + 2 Coenzyme A <-> H+ + NADPH + CoA-disulfide
NADP+ + Coenzyme A + Reduced glutathione <-> H+ + NADPH + CoA-glutathione
L-Cysteine + NADP+ + Reduced glutathione <-> H+ + NADPH + S-Glutathionyl-L-cysteine
NADP+ + 2 Reduced glutathione <-> H+ + NADPH + Oxidized glutathione
 External links Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop


View all entries for EC Class: 1.8.4.2



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