Enzyme Details

 EC Classification 1.14.16.4
 Enzyme name
(recommended)		 tryptophan 5-monooxygenase
 Alternative names L-tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating)
L-tryptophan hydroxylase
indoleacetic acid-5-hydroxylase
tryptophan 5-hydroxylase
tryptophan hydroxylase
 Classification
Oxidoreductases
Acting on paired donors with incorporation of molecular oxygen
With reduced pteridine as one donor, and incorporation of one atom of oxygen
 Catalyses reactions
L-Phenylalanine + O2 + Tetrahydrobiopterin <-> H2O + L-Tyrosine + 6,7-Dihydrobiopterin
L-Tryptophan + O2 + Tetrahydrobiopterin <-> H2O + 6,7-Dihydrobiopterin + 5-Hydroxy-L-tryptophan
L-Phenylalanine + O2 + 6-Methyltetrahydropterin <-> H2O + L-Tyrosine + 6-Methyldihydropterin
L-Tryptophan + O2 + Tetrahydrobiopterin <-> 5-Hydroxy-L-tryptophan + 4a-Hydroxytetrahydrobiopterin
L-Tryptophan + O2 + 6-Methyltetrahydropterin <-> H2O + 5-Hydroxytryptophan + 6-Methyldihydropterin
L-Tryptophan + O2 + 6-Methyltetrahydropterin <-> H2O + 5-Hydroxytryptophan + 4-Hydroxy-6-methyltetrahydropterin
L-Tryptophan + O2 + 6,7-Dimethyl tetrahydropterin <-> Unknown + H2O + 5-Hydroxytryptophan
 External links Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop


View all entries for EC Class: 1.14.16.4



© HITS gGmbH