Enzyme Details

 EC Classification 1.14.16.1
 Enzyme name
(recommended)		 phenylalanine 4-monooxygenase
 Alternative names L-phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating)
phenylalaninase
phenylalanine 4-hydroxylase
phenylalanine hydroxylase
 Classification
Oxidoreductases
Acting on paired donors with incorporation of molecular oxygen
With reduced pteridine as one donor, and incorporation of one atom of oxygen
 Catalyses reactions
L-Phenylalanine + O2 + Tetrahydrobiopterin <-> H2O + L-Tyrosine + 6,7-Dihydrobiopterin
L-Phenylalanine + O2 + 6-Methyltetrahydropterin <-> H2O + L-Tyrosine + 6-Methyldihydropterin
L-Tryptophan + O2 + 6-Methyltetrahydropterin <-> H2O + 5-Hydroxytryptophan + 6-Methyldihydropterin
L-Phenylalanine + O2 + Tetrahydrobiopterin <-> L-Tyrosine + 4a-Hydroxytetrahydrobiopterin
L-Tryptophan + O2 + Tetrahydrobiopterin <-> 5-Hydroxy-L-tryptophan + 4a-Hydroxytetrahydrobiopterin
L-Phenylalanine + O2 + 6,7-Dimethyl-tetrahydropteridine <-> H2O + L-Tyrosine + 6,7-Dimethyl-dihydropteridine
L-Phenylalanine + O2 + Tetrahydrodictyopterin <-> L-Tyrosine + 4a-Hydroxytetrahydrodictyopterin
 External links Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop


View all entries for EC Class: 1.14.16.1



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