Pathway Details

 Recommended name Pantothenate and CoA biosynthesis
 Alternative names
 Reactions
ATP + N-((R)-Pantothenoyl)-L-cysteine <-> ADP + (R)-4'-Phosphopantothenoyl-L-cysteine
NAD+ + (R)-Pantoate <-> NADH + H+ + (R)-4-Dehydropantoate
2-Dehydropantoate + NHDPH <-> (R)-Pantoate + NHDP+
ATP + (R)-Pantothenate <-> ADP + D-4'-Phosphopantothenate
H2O + Holo-[acyl-carrier protein] <-> Apo-[acyl-carrier protein] + 4'-Phosphopantetheine
ATP + L-Cysteine + D-4'-Phosphopantothenate <-> ADP + Phosphate + (R)-4'-Phosphopantothenoyl-L-cysteine
L-Cysteine + CTP + D-4'-Phosphopantothenate <-> Phosphate + CDP + (R)-4'-Phosphopantothenoyl-L-cysteine
H2O + (R)-Pantothenate <-> beta-Alanine + (R)-Pantoate
NAD+ + (R)-3,3-Dimethylmalate <-> NADH + CO2 + alpha-Ketovaline
H2O + N-Carbamoyl-beta-alanine <-> CO2 + NH3 + beta-Alanine
H2O + Dephospho-CoA <-> AMP + 4'-Phosphopantetheine
H2O + Pantetheine <-> Cysteamine + (R)-Pantothenate
ATP + Dephospho-CoA <-> ADP + Coenzyme A
CO2 + 2-Acetolactate <-> 2 Pyruvate
2-Dehydropantoate + 3-APADPH <-> (R)-Pantoate + 3-APADP+
NAD+ + H2O + (R)-4-Dehydropantoate <-> NADH + H+ + (R)-3,3-Dimethylmalate
NAD+ + (R)-3,3-Dimethylmalate <-> NADH + H+ + CO2 + alpha-Ketovaline
Acceptor + (R)-Pantothenate <-> Reduced acceptor + Pantothenol
2,3-Dihydroxy-3-methylbutanoate <-> H2O + alpha-Ketovaline
ATP + Pantetheine <-> ADP + 4'-Phosphopantetheine
H+ + NADPH + alpha-Ketovaline <-> NADP+ + Hydroxyisovalerate
2-Dehydropantoate + 3'-NADPH <-> (R)-Pantoate + 3'-NADP+
ATP + 4'-Phosphopantetheine <-> Diphosphate + Dephospho-CoA
L-Cysteine + CTP + D-4'-Phosphopantothenate <-> Diphosphate + CMP + (R)-4'-Phosphopantothenoyl-L-cysteine
N-((R)-Pantothenoyl)-L-cysteine <-> CO2 + Pantetheine
Coenzyme A + Apo-[acyl-carrier protein] <-> Adenosine 3',5'-bisphosphate + Holo-[acyl-carrier protein]
NADP+ + (R)-Pantoate <-> H+ + NADPH + 2-Dehydropantoate
H2O + 5,10-Methylenetetrahydrofolate + alpha-Ketovaline <-> 5,6,7,8-Tetrahydrofolate + 2-Dehydropantoate
NAD+ + 5,6-Dihydrouracil <-> NADH + H+ + Uracil
L-Valine + 2-Oxoglutarate <-> L-Glutamate + alpha-Ketovaline
L-Aspartate <-> CO2 + beta-Alanine
(R)-4'-Phosphopantothenoyl-L-cysteine <-> CO2 + 4'-Phosphopantetheine
ATP + beta-Alanine + (R)-Pantoate <-> Diphosphate + AMP + (R)-Pantothenate
H+ + NADPH + 3-Methyl-2-oxopentanoate <-> NADP+ + 2-Hydroxy-3-methyl-n-valerate
NADP+ + 5,6-Dihydrouracil <-> H+ + Uracil + NADPH
H2O + 5,6-Dihydrouracil <-> N-Carbamoyl-beta-alanine
2-Dehydropantoate + alpha-NADPH <-> (R)-Pantoate + alpha-NADP+
H+ + NADPH + 2-Acetolactate <-> NADP+ + 2,3-Dihydroxy-3-methylbutanoate
2-Dehydropantoate + tNADPH <-> (R)-Pantoate + tNADP+
 Classification
Metabolism of Cofactors and Vitamins
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