Pathway Details

 Recommended name Biosynthesis of cofactors
 Alternative names
 Reactions
NADP+ + Precorrin 6Y <-> H+ + NADPH + Precorrin 6X
ATP + NH4+ + Deamino-NAD+ <-> NAD+ + H+ + Diphosphate + AMP
H2O + Oxidized dithiothreitol + Phylloquinone <-> 1,4-Dithiothreitol + Vitamin K epoxide
L-Tryptophan + O2 <-> Formylkynurenine
NAD+ + L-Galactose <-> NADH + H+ + L-Galactono-1,4-lactone
Phosphate + Thiamin <-> H2O + Thiamine monophosphate
S-Adenosyl-L-methionine + Precorrin 4 <-> S-Adenosyl-L-homocysteine + Precorrin 5
2 ATP + 2 H2O + 2 L-Glutamine + Hydrogenobyrinate <-> 2 ADP + 2 Phosphate + 2 L-Glutamate + Hydrogenobyrinate a,c diamide
H2O + 5,10-Methenyltetrahydrofolate <-> H+ + 10-Formyltetrahydrofolate
2-Amino-3-oxo-4-phosphonooxybutyrate <-> CO2 + 3-Amino-2-oxopropyl phosphate
NAD+ + L-Dihydroorotate <-> NADH + H+ + Orotate
L-Valine + 2-Oxoglutarate <-> L-Glutamate + alpha-Ketovaline
L-Tyrosine <-> CO2 + Tyramine
NADH + H+ + FAD <-> NAD+ + FADH2
2 NADP+ + Tetrahydrobiopterin <-> 2 H+ + 2 NADPH + Biopterin
ATP + AMP <-> 2 ADP
NAD+ + Dihydrofolate <-> NADH + H+ + Folate
4-Amino-4-deoxychorismate <-> Pyruvate + 4-Aminobenzoate
H2O + N1-(5-Phospho-alpha-D-ribosyl)-5,6-dimethylbenzimidazole <-> Phosphate + alpha-Ribazole
H+ + NADPH + D-Galacturonate <-> NADP+ + L-Galactonate
H2O + GTP <-> Formate + 7,8-Dihydroneopterin 3'-triphosphate
3-Sulfopyruvate <-> CO2 + Sulfoacetaldehyde
ATP + (R)-1-Aminopropan-2-ol + Adenosyl cobyrinate hexaamide <-> ADP + Phosphate + Adenosyl cobinamide
L-Glutamate + GTP + Coenzyme F420-1 <-> Phosphate + GDP + Coenzyme gamma-F420-2
ATP + Adenosyl cobinamide <-> ADP + Adenosyl cobinamide phosphate
ATP + Pyridoxal <-> ADP + Pyridoxal phosphate
Heme <-> Heme O
(2S)-Lactyl-2-diphospho-5'-guanosine + 7,8-Didemethyl-8-hydroxy-5-deazariboflavin <-> GMP + Coenzyme F420-0
2 6,7-Dimethyl-8-(1-D-ribityl)lumazine <-> Riboflavin + 4-(1-D-Ribitylamino)-5-amino-2,6-dihydroxypyrimidine
GTP + D-Mannose 1-phosphate <-> Diphosphate + GDPmannose
ATP + 4-Amino-5-hydroxymethyl-2-methylpyrimidine <-> ADP + 4-Amino-2-methyl-5-phosphomethylpyrimidine
D-Mannose 6-phosphate <-> beta-D-Fructose 6-phosphate
H+ + NADPH + FAD <-> NADP+ + FADH2
Tetrahydrofolyl-[Glu](n) <-> 5,6,7,8-Tetrahydrofolate + Poly-L-glutamate
O2 + 3-(4-Hydroxyphenyl)pyruvate <-> CO2 + Homogentisate
ATP + NAD+ <-> ADP + NADP+
ATP + Formate + 5,6,7,8-Tetrahydrofolate <-> ADP + Phosphate + 10-Formyltetrahydrofolate
4-Aminobenzoate + 2-Amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine <-> H2O + Dihydropteroate
ATP + L-Glutamate + Tetrahydrofolyl-[Glu](n) <-> ADP + Phosphate + Tetrahydrofolyl-[Glu](n)
ATP + Dephospho-CoA <-> ADP + Coenzyme A
S-Adenosyl-L-methionine + 8-Amino-7-oxononanoate <-> 7,8-Diaminononanoate + S-Adenosyl-4-methylthio-2-oxobutanoate
L-Alanine + 6-Carboxyhexanoyl-CoA <-> Coenzyme A + CO2 + 8-Amino-7-oxononanoate
H2O + Nicotinamide <-> NH3 + Nicotinate
2 NAD+ + H2O + UDPglucose <-> 2 NADH + H+ + UDPglucuronate
NAD+ + H2O + D-Erythrose 4-phosphate <-> NADH + H+ + 4-Phospho-D-erythronate
2-Succinylbenzoyl-CoA <-> H2O + 1,4-Dihydroxy-2-naphthoyl-CoA
Nicotinate D-ribonucleotide + Dimethylbenzimidazole <-> Nicotinate + N1-(5-Phospho-alpha-D-ribosyl)-5,6-dimethylbenzimidazole
Uroporphyrinogen III <-> 4 CO2 + Coproporphyrinogen III
Diphosphate + UDP-D-galacturonate <-> UTP + D-Galacturonate 1-phosphate
NADP+ + 5,6,7,8-Tetrahydromethanopterin <-> H+ + NADPH + 7,8-Dihydromethanopterin
2 S-Adenosyl-L-methionine + Precorrin 6Y <-> CO2 + 2 S-Adenosyl-L-homocysteine + Precorrin 8X
H+ + NADPH + 9-cis-Retinal <-> NADP+ + 9-cis-Retinol
H2O + L-Galactono-1,4-lactone <-> L-Galactonate
Pyruvate + ATP <-> Phosphoenolpyruvate + ADP
NAD+ + 4-Phospho-D-erythronate <-> NADH + H+ + 2-Oxo-3-hydroxy-4-phosphobutanoate
ATP + Riboflavin <-> ADP + Riboflavin-5-phosphate
3 O2 + Coproporphyrinogen III <-> 3 H2O2 + Coproporphyrin III
UDPglucuronate <-> UDP-D-galacturonate
ATP + Coenzyme A + 2-Succinylbenzoate <-> Diphosphate + AMP + 2-Succinylbenzoyl-CoA
L-Glutamate + GTP + Coenzyme F420-0 <-> Phosphate + GDP + Coenzyme F420-1
NAD+ + O-Phospho-4-hydroxy-L-threonine <-> NADH + H+ + 2-Amino-3-oxo-4-phosphonooxybutyrate
NAD+ + L-Aspartate <-> NADH + H+ + Iminoaspartate
AMP + NTP <-> ADP + NDP
H2O + L-Gulono-1,4-lactone <-> L-Gulonate
ATP + L-Glutamate + L-Cysteine <-> ADP + Phosphate + gamma-L-Glutamyl-L-cysteine
2 ATP + 2 H2O + 2 L-Glutamine + Cobyrinate <-> 2 ADP + 2 Phosphate + 2 L-Glutamate + Cob(II)yrinate a,c diamide
H2O + Pyridoxal phosphate <-> Phosphate + Pyridoxal
O2 + Pyridoxine phosphate <-> Pyridoxal phosphate + H2O2
Glycine + Succinyl-CoA <-> Coenzyme A + CO2 + 5-Aminolevulinate
2 ATP + H2O + L-Glutamine + Hydrogencarbonate <-> 2 ADP + Phosphate + L-Glutamate + Carbamoyl phosphate
L-Aspartate + O2 <-> H2O2 + Iminoaspartate
ATP + Coenzyme A + Pimelate <-> Diphosphate + AMP + 6-Carboxyhexanoyl-CoA
O2 + 3-Hydroxyanthranilate <-> 2-Amino-3-carboxymuconate semialdehyde
Phosphate + 7,8-Dihydroneopterin <-> H2O + Dihydroneopterin phosphate
NAD+ + Retinol <-> NADH + H+ + all-trans-Retinal
H2O + beta-D-Glucuronide <-> Alcohol + D-Glucuronate
UTP + D-Glucose 1-phosphate <-> Diphosphate + UDPglucose
4-Hydroxybenzoate + n Polyisopentenylpyrophosphate <-> n Diphosphate + 4-Hydroxy-3-polyprenylbenzoate
H2O + Dihydroneopterin triphosphate <-> Diphosphate + Dihydroneopterin phosphate
L-Tryptophan + O2 <-> L-Formylkynurenine
H2O + L-Formylkynurenine <-> Formate + L-Kynurenine
Diphosphate + Orotidine 5'-phosphate <-> 5-Phospho-alpha-D-ribose 1-diphosphate + Orotate
S-Adenosyl-L-methionine + Precorrin 3B <-> S-Adenosyl-L-homocysteine + Precorrin 4
H2O + 4 Porphobilinogen <-> 4 NH3 + Hydroxymethylbilane
Diphosphate + 3'-Dephospho-CoA <-> ATP + 4'-Phosphopantetheine
NADP+ + (R)-Pantoate <-> H+ + NADPH + 2-Dehydropantoate
L-Aspartate <-> CO2 + beta-Alanine
NADH + H+ + 9-cis-Retinal <-> NAD+ + 9-cis-Retinol
D-Ribulose 5-phosphate <-> Formate + 3,4-Dihydroxy-2-butanone 4-phosphate
GTP + (2S)-2-Phospholactate <-> Diphosphate + (2S)-Lactyl-2-diphospho-5'-guanosine
ATP + beta-Alanine + (R)-Pantoate <-> Diphosphate + AMP + (R)-Pantothenate
H2O + 5,10-Methylenetetrahydrofolate + alpha-Ketovaline <-> 5,6,7,8-Tetrahydrofolate + 2-Dehydropantoate
ATP + ADP <-> ATP + ADP
Phosphate + Pyridoxine <-> H2O + Pyridoxine phosphate
5-Aminolevulinate <-> (S)-4-Amino-5-oxopentanoate
3 H2O + GTP <-> Diphosphate + Formate + 2,5-Diamino-6-hydroxy-4-(5'-phosphoribosylamino)-pyrimidine
ATP + UMP <-> ADP + UDP
Chorismate <-> Isochorismate
(R)-4'-Phosphopantothenoyl-L-cysteine <-> CO2 + 4'-Phosphopantetheine
H2O + 7,8-Dihydroneopterin 3'-triphosphate <-> Diphosphate + Dihydroneopterin phosphate
L-Aspartate + Carbamoyl phosphate <-> Phosphate + N-Carbamoyl-L-aspartate
NAD+ + Precorrin 2 <-> NADH + H+ + Sirohydrochlorin
CO2 + Diphosphate + Nicotinate D-ribonucleotide <-> 5-Phospho-alpha-D-ribose 1-diphosphate + Pyridine-2,3-dicarboxylate
4-(1-D-Ribitylamino)-5-amino-2,6-dihydroxypyrimidine + 3,4-Dihydroxy-2-butanone 4-phosphate <-> Phosphate + 2 H2O + 6,7-Dimethyl-8-(1-D-ribityl)lumazine
H2O + 3-Hydroxykynurenine <-> L-Alanine + 3-Hydroxyanthranilate
ATP + D-1-Aminopropan-2-ol O-phosphate + Adenosyl cobyrinate hexaamide <-> ADP + Phosphate + Adenosyl cobinamide phosphate
NAD+ + (2R)-3-Sulfolactate <-> NADH + H+ + 3-Sulfopyruvate
Diphosphate + Nicotinate D-ribonucleotide <-> 5-Phospho-alpha-D-ribose 1-diphosphate + Nicotinate
2 S-Adenosyl-L-methionine + Uroporphyrinogen III <-> 2 S-Adenosyl-L-homocysteine + Precorrin 2
UTP + alpha-D-Glucose 1-phosphate <-> Diphosphate + UDP-D-glucose
2-Oxoglutarate + Isochorismate <-> CO2 + 5-Enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate
H2O + 2-Succinylbenzoate <-> 2-Succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate
2-Oxoglutarate + O-Phospho-4-hydroxy-L-threonine <-> L-Glutamate + 2-Oxo-3-hydroxy-4-phosphobutanoate
ATP + Thiamin <-> AMP + Thiamine diphosphate
NADP+ + 5-Amino-6-(5'-phosphoribitylamino)uracil <-> H+ + NADPH + 5-Amino-6-(5'-phosphoribosylamino)uracil
H2O + Pyridine-2,3-dicarboxylate <-> 2-Amino-3-carboxymuconate semialdehyde
NADP+ + L-Gulonate <-> H+ + NADPH + D-Glucuronate
H+ + NADPH + O2 + L-Kynurenine <-> H2O + NADP+ + 3-Hydroxy-L-kynurenine
1-Deoxy-D-xylulose 5-phosphate + 3-Amino-2-oxopropyl phosphate <-> Phosphate + 2 H2O + Pyridoxine phosphate
GTP + D-Mannose 1-phosphate <-> Diphosphate + GDP-D-mannose
NADP+ + 5,10-Methylenetetrahydrofolate <-> H+ + NADPH + 5,10-Methenyltetrahydrofolate
ATP + 4-Amino-2-methyl-5-phosphomethylpyrimidine <-> ADP + 2-Methyl-4-amino-5-hydroxymethylpyrimidine diphosphate
H2O + O2 + Spermine <-> H2O2 + 3-Aminopropanal + Spermidine
H2O + Glycine + 5,10-Methylenetetrahydrofolate <-> L-Serine + 5,6,7,8-Tetrahydrofolate
H2O + Formylkynurenine <-> Formate + L-Kynurenine
ATP + Nicotinate D-ribonucleotide <-> Diphosphate + Deamino-NAD+
GDP-D-mannose <-> GDP-L-galactose
H+ + NADPH + all-trans-Retinal <-> NADP+ + Retinol
L-Aspartate + GTP + IMP <-> Phosphate + GDP + N6-(1,2-Dicarboxyethyl)-AMP
Coenzyme A + Homocitrate <-> H2O + Acetyl-CoA + 2-Oxoglutarate
GMP + Coenzyme B12 <-> Adenosine-GDP-cobinamide + alpha-Ribazole
NADP+ + 5,6,7,8-Tetrahydrofolate <-> H+ + NADPH + Dihydrofolate
Hydroxymethylbilane <-> H2O + Uroporphyrinogen III
NADP+ + Reduced FMN <-> H+ + NADPH + Riboflavin-5-phosphate
Pyruvate + 4-Hydroxybenzoate <-> Chorismate
2-Amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-Aminobenzoate <-> Diphosphate + Dihydropteroate
NAD+ + H2O + beta-Aminopropion aldehyde <-> NADH + H+ + beta-Alanine
ATP + 5-(2-Hydroxyethyl)-4-methylthiazole <-> ADP + 4-Methyl-5-(2-phosphoethyl)-thiazole
NAD+ + 5,10-Methylenetetrahydrofolate <-> NADH + H+ + 5,10-Methenyltetrahydrofolate
NADP+ + Dihydrofolate <-> H+ + NADPH + Folate
Heme O <-> Heme A
ATP + 4'-Phosphopantetheine <-> Diphosphate + Dephospho-CoA
GTP + Adenosyl cobinamide <-> GDP + Adenosyl cobinamide phosphate
ATP + L-Glutamate + 5,6,7,8-Tetrahydrofolate <-> ADP + Phosphate + Tetrahydrofolyl-[Glu](2)
2 S-Adenosyl-L-methionine + Coproporphyrinogen III <-> 2 L-Methionine + 2 CO2 + 2 5'-Deoxyadenosine + Protoporphyrinogen IX
ATP + (R)-Pantothenate <-> ADP + D-4'-Phosphopantothenate
ATP + L-Glutamate + Dihydropteroate <-> ADP + Phosphate + Dihydrofolate
S-Adenosyl-L-homocysteine + Acetate + Precorrin 6X <-> H2O + S-Adenosyl-L-methionine + Precorrin 5
2-Methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-Methyl-5-(2-phosphoethyl)-thiazole <-> Diphosphate + Thiamine monophosphate
ATP + NH3 + UTP <-> ADP + Phosphate + CTP
ATP + Glycine + gamma-L-Glutamyl-L-cysteine <-> ADP + Phosphate + Reduced glutathione
L-Glutamine + Chorismate <-> L-Glutamate + 4-Amino-4-deoxychorismate
7,8-Dihydroneopterin <-> Glycolaldehyde + 2-Amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine
Phosphate + Diphosphate + S-Adenosyl-L-methionine <-> ATP + H2O + L-Methionine
Fe2+ + Protoporphyrin <-> 2 H+ + Heme
GTP + Adenosyl cobinamide phosphate <-> Diphosphate + Adenosine-GDP-cobinamide
2 NAD+ + H2O + UDP-D-glucose <-> 2 NADH + H+ + UDPglucuronate
Cobalt-precorrin 8 <-> Cobyrinate
NAD+ + 5,6,7,8-Tetrahydrofolate <-> NADH + H+ + Folate
H2O + 1,4-Dihydroxy-2-naphthoyl-CoA <-> Coenzyme A + 1,4-Dihydroxy-2-naphthoate
GDPmannose <-> GDP-L-galactose
D-Mannose 6-phosphate <-> D-Mannose 1-phosphate
7,8-Dihydroneopterin 3'-triphosphate <-> Triphosphate + 6-Pyruvoyltetrahydropterin
4-Amino-5-hydroxymethyl-2-methylpyrimidine <-> Aminoimidazole ribotide
NAD+ + 5,6,7,8-Tetrahydrofolate <-> NADH + H+ + Dihydrofolate
ATP + CDP <-> ADP + CTP
Orotidine 5'-phosphate <-> CO2 + UMP
3 H2O + 7,8-Dihydroneopterin 3'-triphosphate <-> 3 Phosphate + 7,8-Dihydroneopterin
S-Adenosyl-L-methionine + gamma-Tocopherol <-> S-Adenosyl-L-homocysteine + alpha-Tocopherol
O2 + beta-Carotene <-> 2 all-trans-Retinal
H2O + 3-Hydroxy-L-kynurenine <-> L-Alanine + 3-Hydroxyanthranilate
ATP + CO2 + 7,8-Diaminononanoate <-> ADP + Phosphate + Dethiobiotin
ATP + H2O + L-Glutamine + UTP <-> ADP + Phosphate + L-Glutamate + CTP
H2O + (2R)-2-Phospho-3-sulfolactate <-> Phosphate + (2R)-3-Sulfolactate
ATP + UDP <-> ADP + UTP
ATP + L-Glutamate + tRNA(Glu) <-> Diphosphate + AMP + L-Glutamyl-tRNA(Glu)
2 5-Aminolevulinate <-> 2 H2O + Porphobilinogen
2 H+ + Siroheme <-> Fe2+ + Sirohydrochlorin
N6-(1,2-Dicarboxyethyl)-AMP <-> AMP + Fumarate
L-Aspartate + NADP+ <-> H+ + NADPH + Iminoaspartate
ATP + Pyridoxine <-> ADP + Pyridoxine phosphate
O2 + L-Dihydroorotate <-> H2O2 + Orotate
L-Cysteine + CTP + D-4'-Phosphopantothenate <-> Diphosphate + CMP + (R)-4'-Phosphopantothenoyl-L-cysteine
Phosphate + 2 H2O + Pyridine-2,3-dicarboxylate <-> Glycerone phosphate + Iminoaspartate
H2O + L-Dihydroorotate <-> N-Carbamoyl-L-aspartate
2 NADP+ + 5,6,7,8-Tetrahydrofolate <-> 2 H+ + 2 NADPH + Folate
4 ATP + 4 H2O + 4 L-Glutamine + Adenosyl cobyrinate a,c diamide <-> 4 ADP + 4 Phosphate + 4 L-Glutamate + Adenosyl cobyrinate hexaamide
Fumarate + L-Dihydroorotate <-> Succinate + Orotate
ATP + Thiamine monophosphate <-> ADP + Thiamine diphosphate
H2O + 5-Amino-6-(5'-phosphoribitylamino)uracil <-> Phosphate + 4-(1-D-Ribitylamino)-5-amino-2,6-dihydroxypyrimidine
ATP + Riboflavin-5-phosphate <-> Diphosphate + FAD
NADP+ + Gulonate <-> H+ + NADPH + Glucuronate
NAD+ + Homoisocitrate <-> NADH + H+ + CO2 + 2-Oxoadipate
Phosphoenolpyruvate + Sulfite <-> (2R)-2-Phospho-3-sulfolactate
NAD+ + Reduced FMN <-> NADH + H+ + Riboflavin-5-phosphate
O2 + Coproporphyrinogen III <-> 2 H2O + 2 CO2 + Protoporphyrinogen IX
Precorrin 8X <-> Hydrogenobyrinate
 Classification
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