Pathway Details

 Recommended name Benzoate degradation
 Alternative names
 Reactions
H2O + 4-Carboxy-2-hydroxymuconate semialdehyde <-> Formate + 4-Carboxy-2-oxo-4-pentanoate
Succinyl-CoA + 3-Oxoadipate <-> Succinate + 3-Oxoadipyl-CoA
3,4-Dihydroxybenzoate <-> Gallate
Pyruvate + Acetaldehyde <-> 4-Hydroxy-2-oxopentanoate
2 Acetyl-CoA <-> Coenzyme A + Acetoacetyl-CoA
H2O + 2-Ketocyclohexane-1-carboxyl-CoA <-> 6-Carboxyhexanoyl-CoA
CO2 + 2-Hydroxymuconate semialdehyde <-> 3-Carboxy-2-hydroxymuconate semialdehyde
Parapyruvate <-> H2O + 4-Methylene-2-oxoglutarate
2 H2O + 6-Ketoxycyclohex-1-ene-1-carboxyl-CoA <-> 3-Hydroxypimeloyl-CoA
4-Bromobenzoylformate <-> CO2 + 4-Bromobenzaldehyde
4-Hydroxy-4-methyl-2-oxoglutarate <-> H2O + 4-Carboxy-2-oxo-4-pentanoate
4-Ethylbenzoylformic acid <-> CO2 + 4-Ethylbenzaldehyde
H+ + NADPH + O2 + 3,4-Dihydroxybenzoate <-> H2O + NADP+ + CO2 + Benzene-1,2,4-triol
Parapyruvate <-> 2 Pyruvate
2,3-Dihydroxybenzoate <-> CO2 + Catechol
4-Hydroxyphenylglyoxylate <-> CO2 + 4-Hydroxybenzaldehyde
H+ + NADPH + O2 + Anthranilate <-> NADP+ + CO2 + NH3 + Catechol
Benzoate <-> 3-Hydroxybenzoate
NADP+ + 3-Oxoadipate <-> H+ + NADPH + 2-Maleylacetate
3-Carboxy-2,5-dihydro-5-oxofuran-2-acetate <-> 3-Carboxy-cis,cis-muconate
H+ + NADPH + O2 + 3-Hydroxybenzoate <-> H2O + NADP+ + 3,4-Dihydroxybenzoate
NAD+ + 2-Hydroxycyclohexane-1-carboxyl-CoA <-> NADH + H+ + 2-Ketocyclohexane-1-carboxyl-CoA
OH- + 4-Sulfolactone <-> 2-Maleylacetate + HSO3-
2,5-Dihydro-5-oxofuran-2-acetate <-> cis,cis-Muconate
NADP+ + HCl + 4-Chlorobenzoyl-CoA <-> H+ + NADPH + 2,4-Dichlorobenzoyl-CoA
H+ + NADPH + O2 + 4-Aminobenzoate <-> H2O + NADP+ + CO2 + 4-Hydroxyaniline
alpha-Oxo-benzeneacetic acid <-> CO2 + Benzaldehyde
O2 + Gallate <-> H2O + 2-Pyrone-4,6-dicarboxylate
2-Maleylacetate <-> 3-Hydroxy-cis,cis-muconate
H2O + Cyclohex-1-ene-1-carboxyl-CoA <-> 2-Hydroxycyclohexane-1-carboxyl-CoA
(S)-4-Hydroxymandelate + Acceptor <-> Reduced acceptor + 4-Hydroxyphenylglyoxylate
O2 + 3,4-Dihydroxybenzoate <-> 3-Carboxy-cis,cis-muconate
S-1,5-Cyclohexadiene-1-carboxylate coenzymeA <-> Cyclohex-2,5-diene-1-carboxyl-CoA
O2 + 3,4-Dihydroxybenzoate <-> 4-Carboxy-2-hydroxymuconate semialdehyde
(S)-3-Hydroxybutanoyl-CoA <-> H2O + Crotonoyl-CoA
NAD+ + 2-Hydroxy-2-hydropyrone-4,6-dicarboxylate <-> NADH + H+ + 2-Pyrone-4,6-dicarboxylate
ATP + Coenzyme A + 4-Chlorobenzoate <-> Diphosphate + AMP + 4-Chlorobenzoyl-CoA
H2O + 2-Pyrone-4,6-dicarboxylate <-> 4-Carboxy-2-hydroxyhexa-2,4-dienedioate
NADP+ + 2-Hydroxy-2-hydropyrone-4,6-dicarboxylate <-> H+ + NADPH + 2-Pyrone-4,6-dicarboxylate
Acceptor + Cyclohexane-1-carboxyl-CoA <-> Reduced acceptor + Cyclohex-1-ene-1-carboxyl-CoA
ATP + Coenzyme A + 4-Hydroxybenzoate <-> Diphosphate + AMP + 4-Hydroxybenzoyl-CoA
H2O + 6-Carboxyhex-2-enoyl-CoA <-> 3-Hydroxypimeloyl-CoA
H2O + 4-Hydroxybenzoyl-pantetheine <-> 4-Hydroxybenzoate + Pantetheine
(S)-5-Oxo-2,5-dihydrofuran-2-acetate <-> 2-Oxo-2,3-dihydrofuran-5-acetate
O2 + 4-Hydroxy-3-methoxy-benzenemethanol <-> H2O2 + 4-Hydroxy-3-methoxy-benzaldehyde
2 ATP + 2 H2O + Benzoyl-CoA + Reduced acceptor <-> 2 ADP + 2 Phosphate + Acceptor + S-1,5-Cyclohexadiene-1-carboxylate coenzymeA
2-Hydroxy-2-hydropyrone-4,6-dicarboxylate <-> 4-Carboxy-2-hydroxymuconate semialdehyde
4-Hydroxy-4-methyl-2-oxoglutarate <-> 2 Pyruvate
NADH + H+ + O2 + Phthalate <-> NAD+ + cis-4,5-Dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate
NAD+ + cis-1,2-Dihydrobenzene-1,2-diol <-> NADH + H+ + Catechol
NADH + H+ + O2 + 3-Hydroxybenzoate <-> NAD+ + H2O + 2,5-Dihydroxybenzoate
NAD+ + H2O + 2-Hydroxymuconate semialdehyde <-> NADH + H+ + 2-Hydroxymuconate
NADH + H+ + O2 + 4-Aminobenzoate <-> NAD+ + H2O + CO2 + 4-Hydroxyaniline
4-Aminobenzoate + 4-Aminobenzenesulfonate <-> 4 H+ + 4-Carboxy-4'-sulfoazobenzene
H+ + NADPH + O2 + Benzoate <-> H2O + NADP+ + 4-Hydroxybenzoate
NAD+ + Coenzyme A + Acetaldehyde <-> NADH + H+ + Acetyl-CoA
4-Carboxy-4-hydroxy-2-oxoadipate <-> H2O + 4-Carboxy-2-oxo-3-hexenedioate
H2O + 4-Chlorobenzoyl-CoA <-> Cl- + 4-Hydroxybenzoyl-CoA
H2O + 2-Oxo-2,3-dihydrofuran-5-acetate <-> 3-Oxoadipate
O2 + Catechol <-> 2-Hydroxymuconate semialdehyde
NAD+ + 3-Hydroxypimeloyl-CoA <-> NADH + H+ + 3-Oxopimeloyl-CoA
4-Carboxy-4-hydroxy-2-oxoadipate <-> H2O + 4-Carboxy-2-hydroxy-cis,cis-muconate
O2 + 4-Sulfocatechol <-> 3-Sulfomuconate
NAD+ + H2O + Vanillate <-> NADH + H+ + O2 + 4-Hydroxy-3-methoxy-benzaldehyde
NADH + H+ + O2 + 4-Hydroxybenzoate <-> NAD+ + H2O + 3,4-Dihydroxybenzoate
H2O + (Z)-5-Oxohex-2-enedioate <-> CO2 + 4-Hydroxy-2-oxopentanoate
4-Carboxy-2-oxo-3-hexenedioate <-> 4-Carboxy-2-hydroxyhexa-2,4-dienedioate
NADH + H+ + O2 + Toluene-4-sulfonate <-> NAD+ + H2O + 4-Sulfobenzyl alcohol
NADH + H+ + O2 + Anthranilate <-> NAD+ + CO2 + NH3 + Catechol
O2 + 4-Methoxybenzoate + Reduced acceptor <-> H2O + Formaldehyde + 4-Hydroxybenzoate + Acceptor
4-Hydroxyphthalate <-> CO2 + 3-Hydroxybenzoate
H2O + 2-Hydroxy-2,4-pentadienoate <-> 4-Hydroxy-2-oxopentanoate
S-1,5-Cyclohexadiene-1-carboxylate coenzymeA <-> Cyclohex-1,4-diene-1-carboxyl-CoA
H2O + 4-Hydroxybenzoyl-(3'-dephospho)-CoA <-> 4-Hydroxybenzoate + 3'-Dephospho-CoA
O2 + Catechol <-> cis,cis-Muconate
H2O + 4-Hydroxybenzoate + Acceptor <-> O2 + 4-Hydroxybenzaldehyde + Reduced acceptor
4-Carboxy-4-hydroxy-2-oxoadipate <-> Pyruvate + Oxaloacetate
NAD+ + (3S,4R)-3,4-Dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate <-> NADH + H+ + CO2 + 3,4-Dihydroxybenzoate
Coenzyme A + 3-Oxopimeloyl-CoA <-> Acetyl-CoA + Glutaryl-CoA
NAD+ + 3-Oxoadipate <-> NADH + H+ + 2-Maleylacetate
(Z)-5-Oxohex-2-enedioate <-> CO2 + 2-Hydroxy-2,4-pentadienoate
H2O + NADP+ + 4-Hydroxybenzaldehyde <-> H+ + NADPH + 4-Hydroxybenzoate
NAD+ + cis-4,5-Dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate <-> NADH + H+ + 4,5-Dihydroxyphthalate
Acetyl-CoA + Succinyl-CoA <-> Coenzyme A + 3-Oxoadipyl-CoA
(S)-4-Hydroxymandelate <-> (R)-4-Hydroxymandelate
ATP + Coenzyme A + Benzoate <-> Diphosphate + AMP + Benzoyl-CoA
4-Methylbenzoylformic acid <-> CO2 + p-Tolualdehyde
H2O + 4-Hydroxybenzoyl-CoA <-> Coenzyme A + 4-Hydroxybenzoate
NAD+ + H2O + 4-Hydroxybenzaldehyde <-> NADH + H+ + 4-Hydroxybenzoate
Formate + 2-Hydroxy-2,4-pentadienoate <-> H2O + 2-Hydroxymuconate semialdehyde
NAD+ + 1,6-Dihydroxy-cis-2,4-cyclohexadiene-1-carboxylic acid <-> NADH + H+ + CO2 + Catechol
ATP + Coenzyme A + 2,4-Dichlorobenzoate <-> Diphosphate + AMP + 2,4-Dichlorobenzoyl-CoA
H+ + NADPH + O2 + Anthranilate <-> NADP+ + NH3 + 2,3-Dihydroxybenzoate
H2O + S-1,5-Cyclohexadiene-1-carboxylate coenzymeA <-> 6-Hydroxycyclohex-1-enecarbonyl-CoA
O2 + Gallate <-> 4-Carboxy-2-hydroxyhexa-2,4-dienedioate
2-Carboxy-2,5-dihydro-5-oxofuran-2-acetate <-> CO2 + 2-Oxo-2,3-dihydrofuran-5-acetate
2,5-Dihydro-5-oxofuran-2-acetate <-> 2-Oxo-2,3-dihydrofuran-5-acetate
Glutaryl-CoA + Acceptor <-> Reduced acceptor + Glutaconyl-1-CoA
2 H+ + O2 + 4-Aminobenzenesulfonate <-> NH3 + 4-Sulfocatechol
NH3 + 3,4-Dihydroxybenzoate <-> 2 H+ + O2 + 4-Aminobenzoate
2-Hydroxymuconate <-> (Z)-5-Oxohex-2-enedioate
cis,cis-Muconate <-> (S)-5-Oxo-2,5-dihydrofuran-2-acetate
NADH + H+ + O2 + 3,4-Dihydroxybenzoate <-> NAD+ + H2O + CO2 + Benzene-1,2,4-triol
4-Nitrobenzoylformate <-> CO2 + p-Nitrobenzaldehyde
O2 + 3-O-Methylgallate <-> Methanol + 2-Pyrone-4,6-dicarboxylate
NAD+ + H2O + 4-Sulfobenzaldehyde <-> NADH + H+ + 4-Sulfobenzoate
ATP + Coenzyme A + Cyclohexane-1-carboxylate <-> Diphosphate + AMP + Cyclohexane-1-carboxyl-CoA
NADH + H+ + O2 + Vanillate <-> NAD+ + H2O + Formaldehyde + 3,4-Dihydroxybenzoate
Methanol + Gallate <-> H2O + 3-O-Methylgallate
4-Methoxybenzoylformic acid <-> CO2 + 4-Methoxybenzaldehyde
4-Fluorobenzoylformate <-> CO2 + 4-Fluorobenzaldehyde
NAD+ + 6-Hydroxycyclohex-1-enecarbonyl-CoA <-> NADH + H+ + 6-Ketoxycyclohex-1-ene-1-carboxyl-CoA
NAD+ + 4-Sulfobenzyl alcohol <-> NADH + H+ + 4-Sulfobenzaldehyde
H+ + NADPH + O2 + 4-Hydroxybenzoate <-> H2O + NADP+ + 3,4-Dihydroxybenzoate
H2O + NADP+ + 4-Carboxy-2-hydroxymuconate semialdehyde <-> H+ + NADPH + 4-Carboxy-2-hydroxy-cis,cis-muconate
NADH + H+ + O2 + Benzoate <-> NAD+ + CO2 + Catechol
2-Hydroxy-4-oxobutane-1,2,4-tricarboxylate <-> H2O + (E)-4-Oxobut-1-ene-1,2,4-tricarboxylate
2-Carboxy-2,5-dihydro-5-oxofuran-2-acetate <-> 3-Carboxy-cis,cis-muconate
4,5-Dihydroxyphthalate <-> CO2 + 3,4-Dihydroxybenzoate
3-Sulfomuconate <-> 4-Sulfolactone
NADH + H+ + O2 + Terephthalate <-> NAD+ + (3S,4R)-3,4-Dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate
3,4-Dihydroxybenzoate <-> CO2 + Catechol
NADP+ + (S)-3-Hydroxybutanoyl-CoA <-> H+ + NADPH + Acetoacetyl-CoA
O2 + Benzene-1,2,4-triol <-> 3-Hydroxy-cis,cis-muconate
4-Chloro-2-Oxobenzeneacetic acid <-> CO2 + 4-Chlorobenzaldehyde
O2 + 2,3-Dihydroxybenzoate <-> 3-Carboxy-2-hydroxymuconate semialdehyde
O2 + 3-Hydroxybenzoate + Reduced acceptor <-> H2O + 2,3-Dihydroxybenzoate + Acceptor
H+ + NADPH + O2 + 4-Hydroxybenzoate <-> H2O + NADP+ + CO2 + Hydroquinone
NAD+ + 6-Carboxyhexanoyl-CoA <-> NADH + H+ + 6-Carboxyhex-2-enoyl-CoA
NADH + H+ + O2 + 4-Sulfobenzoate <-> NAD+ + 3,4-Dihydroxybenzoate + Sulfite
Glutaconyl-1-CoA <-> CO2 + Crotonoyl-CoA
 Classification
Xenobiotics Biodegradation and Metabolism
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