Pathway Details

 Recommended name Arginine and Proline metabolism
 Alternative names
 Reactions
5-Amino-2-oxopentanoate <-> H2O + 1-Pyrroline-2-carboxylate
N2-Succinyl-L-arginine <-> CO2 + 2 NH3 + N2-Succinyl-L-ornithine
trans-4-Hydroxy-L-proline <-> cis-4-Hydroxy-D-proline
trans-4-Hydroxy-L-proline + Acceptor <-> Reduced acceptor + L-1-Pyrroline-3-hydroxy-5-carboxylate
Putrescine + [eIF5A-precursor]-deoxyhypusine <-> Homospermidine + [eIF5A-precursor]-lysine
L-Proline + NADP+ <-> H+ + NADPH + 1-Pyrroline-2-carboxylate
H2O + NADP+ + N2-(D-1,3-Dicarboxypropyl)-L-arginine <-> H+ + L-Arginine + NADPH + 2-Oxoglutarate
H2O + L-Glutamate + NADP+ <-> H+ + NADPH + NH3 + 2-Oxoglutarate
H2O + L-Arginine <-> NH3 + L-Citrulline
H2O + Urea <-> CO2 + 2 NH3
NAD+ + H2O + Formaldehyde <-> NADH + H+ + Formate
H2O + L-1-Pyrroline-3-hydroxy-5-carboxylate <-> L-4-Hydroxyglutamate semialdehyde
ATP + N-Acetyl-L-glutamate <-> ADP + N-Acetyl-L-glutamyl 5-phosphate
Spermidine + [eIF5A-precursor]-lysine <-> 1,3-Diaminopropane + [eIF5A-precursor]-deoxyhypusine
ATP + L-Proline + tRNA(Pro) <-> Diphosphate + AMP + L-Prolyl-tRNA(Pro)
L-Proline + NADP+ <-> H+ + NADPH + (S)-1-Pyrroline-5-carboxylate
L-Glutamate 5-semialdehyde <-> H2O + (S)-1-Pyrroline-5-carboxylate
NAD+ + 2 H2O + L-1-Pyrroline-3-hydroxy-5-carboxylate <-> NADH + H+ + L-erythro-4-Hydroxyglutamate
L-Arginine <-> L-Arginine
H2O + Sarcosine + Acceptor <-> Glycine + Formaldehyde + Reduced acceptor
H2O + Agmatine <-> Urea + Putrescine
4-Coumaroyl-CoA + Agmatine <-> Coenzyme A + N-(4-Guanidinobutyl)-4-hydroxycinnamide
S-Adenosyl-L-methionine + Guanidinoacetate <-> S-Adenosyl-L-homocysteine + Creatine
H2O + O2 + D-Proline <-> NH3 + H2O2 + 2-Oxopentanoate
NAD+ + trans-4-Hydroxy-L-proline <-> NADH + H+ + L-1-Pyrroline-3-hydroxy-5-carboxylate
NADP+ + trans-4-Hydroxy-L-proline <-> H+ + NADPH + 4-Oxoproline
2-Oxoglutarate + N2-Acetyl-L-ornithine <-> L-Glutamate + N-Acetyl-L-glutamate 5-semialdehyde
L-Proline + Acceptor <-> Reduced acceptor + (S)-1-Pyrroline-5-carboxylate
H2O + NADP+ + N2-(1-Carboxyethyl)-L-arginine <-> Pyruvate + H+ + L-Arginine + NADPH
H2O + N1-Acetylputrescine <-> Acetate + Putrescine
ATP + Creatine <-> ADP + Phosphocreatine
Glycine + L-Arginine <-> L-Ornithine + Guanidinoacetate
1,3-Diaminopropane + S-Adenosylmethioninamine <-> 5'-Deoxy-5'-(methylthio)adenosine + Bis(3-aminopropyl)amine
L-Ornithine + Carbamoyl phosphate <-> Phosphate + L-Citrulline
ATP + Urea + Hydrogencarbonate <-> ADP + Phosphate + Urea-1-carboxylate
H+ + L-Arginine + NADPH + O2 <-> NADP+ + L-Citrulline + Nitric oxide
H2O + NADP+ + 4-Aminobutanal <-> H+ + NADPH + 4-Aminobutanoate
L-Arginine + Succinyl-CoA <-> Coenzyme A + N2-Succinyl-L-arginine
NAD+ + L-Proline <-> NADH + H+ + 1-Pyrroline-2-carboxylate
H2O + Creatinine <-> NH3 + N-Methylhydantoin
2-Oxoglutarate + N2-Succinyl-L-ornithine <-> L-Glutamate + N2-Succinyl-L-glutamate 5-semialdehyde
NAD+ + L-Proline <-> NADH + H+ + (S)-1-Pyrroline-5-carboxylate
L-Arginine + 4-Aminobutanoate <-> L-Ornithine + 4-Guanidinobutanoate
H2O + N-Carbamoylputrescine <-> CO2 + NH3 + Putrescine
NADPH + 2 Hexacyanoferrate(III) <-> H+ + NADP+ + 2 Hexacyanoferrate(II)
H2O + Creatinine <-> Creatine
H2O + Agmatine <-> NH3 + N-Carbamoylputrescine
H+ + NADPH + O2 + 2 N-(omega)-Hydroxyarginine <-> NADP+ + 2 L-Citrulline + 2 Nitric oxide
2 ATP + H2O + CO2 + NH3 <-> 2 ADP + Phosphate + Carbamoyl phosphate
H2O + O2 + D-Alanine <-> Pyruvate + NH3 + H2O2
H2O + N-Carbamoylsarcosine <-> CO2 + NH3 + Sarcosine
NAD+ + L-erythro-4-Hydroxyglutamate <-> NADH + H+ + H2O + L-4-Hydroxyglutamate semialdehyde
NAD+ + 2 H2O + (S)-1-Pyrroline-5-carboxylate <-> NADH + H+ + L-Glutamate
NAD+ + H2O + N2-Succinyl-L-glutamate 5-semialdehyde <-> NADH + H+ + N2-Succinyl-L-glutamate
Putrescine + S-Adenosylmethioninamine <-> 5'-Deoxy-5'-(methylthio)adenosine + Spermidine
Acetate + 4-Aminobutanoate <-> H2O + 4-Acetamidobutanoate
Spermidine + S-Adenosylmethioninamine <-> 5'-Deoxy-5'-(methylthio)adenosine + Spermine
H2O + N2-Acetyl-L-ornithine <-> Acetate + L-Ornithine
NADP+ + trans-4-Hydroxy-L-proline <-> H+ + NADPH + L-1-Pyrroline-3-hydroxy-5-carboxylate
H2O + 1-Pyrroline-4-hydroxy-2-carboxylate <-> 2-Oxo-4-hydroxy-5-aminovalerate
L-Glutamate + Acetyl-CoA <-> Coenzyme A + N-Acetyl-L-glutamate
H2O + Creatine <-> Urea + Sarcosine
H2O + O2 + Putrescine <-> NH3 + H2O2 + 4-Aminobutanal
H2O + Urea-1-carboxylate <-> 2 CO2 + 2 NH3
ATP + CO2 + NH3 <-> ADP + Carbamoyl phosphate
D-4-Hydroxy-2-oxoglutarate <-> Pyruvate + Glyoxylate
L-Arginine <-> CO2 + Agmatine
H2O + N2-Succinyl-L-glutamate <-> L-Glutamate + Succinate
H2O + Homocarnosine <-> L-Histidine + 4-Aminobutanoate
L-Glutamine + D-Proline <-> Linatine
H2O + O2 + N1-Acetylputrescine <-> NH3 + H2O2 + N4-Acetylaminobutanal
L-Ornithine + 2-Oxoglutarate <-> L-Glutamate + L-Glutamate 5-semialdehyde
H+ + L-Arginine + NADPH + O2 <-> H2O + NADP+ + N-(omega)-Hydroxyarginine
5-Aminopentanoate + Lipoate <-> D-Proline + Dihydrolipoate
2 H2O + N2-Succinyl-L-arginine <-> CO2 + 2 NH3 + N2-Succinyl-L-ornithine
ATP + L-Arginine <-> ADP + L-Arginine phosphate
2-Oxoglutarate + Putrescine <-> L-Glutamate + 4-Aminobutanal
D-Aspartate + D-4-Hydroxy-2-oxoglutarate <-> Oxaloacetate + L-erythro-4-Hydroxyglutamate
ATP + 2 H2O + N-Methylhydantoin <-> ADP + Phosphate + N-Carbamoylsarcosine
N(omega)-(L-Arginino)succinate <-> L-Arginine + Fumarate
NADH + 2 Hexacyanoferrate(III) <-> NAD+ + H+ + 2 Hexacyanoferrate(II)
H2O + NADP+ + D-Nopaline <-> H+ + L-Arginine + NADPH + 2-Oxoglutarate
H2O + O2 + D-Methionine <-> NH3 + H2O2 + 4-Methylthio-2-oxobutanoate
O2 + 3,4-Dehydro-L-proline <-> H2O2 + Pyrrole-2-carboxylate
H2O + O2 + D-Phenylalanine <-> NH3 + H2O2 + Phenylpyruvate
L-Lysine + Carbamoyl phosphate <-> Phosphate + L-Homocitrulline
L-Proline + O2 + 2-Oxoglutarate <-> CO2 + Succinate + trans-4-Hydroxy-L-proline
H2O + L-Glutamine <-> L-Glutamate + NH3
NAD+ + H2O + 4-Guanidinobutanal <-> NADH + H+ + 4-Guanidinobutanoate
NAD+ + trans-4-Hydroxy-L-proline <-> NADH + H+ + 4-Oxoproline
Acetyl-CoA + Putrescine <-> Coenzyme A + N1-Acetylputrescine
CO2 + 4-Guanidinobutanal <-> 5-Guanidino-2-oxopentanoate
L-Ornithine <-> CO2 + Putrescine
2 H2O + NADP+ + (S)-1-Pyrroline-5-carboxylate <-> H+ + L-Glutamate + NADPH
H2O + Acceptor + Spermidine <-> 4-Aminobutanal + Reduced acceptor + 1,3-Diaminopropane
O2 + D-Proline <-> H2O2 + 1-Pyrroline-2-carboxylate
H2O + 4-Guanidinobutanamide <-> NH3 + 4-Guanidinobutanoate
H2O + L-Arginine + O2 <-> NH3 + H2O2 + 5-Guanidino-2-oxopentanoate
NAD+ + H2O + 4-Aminobutanal <-> NADH + H+ + 4-Aminobutanoate
NAD+ + H2O + L-Glutamate <-> NADH + H+ + NH3 + 2-Oxoglutarate
ATP + Guanidinoacetate <-> ADP + Phosphoguanidinoacetate
2 H2O + NADP+ + L-1-Pyrroline-3-hydroxy-5-carboxylate <-> H+ + NADPH + L-erythro-4-Hydroxyglutamate
NAD+ + H2O + N4-Acetylaminobutanal <-> NADH + H+ + 4-Acetamidobutanoate
ATP + L-Glutamate <-> ADP + L-Glutamyl 5-phosphate
2-Oxoglutarate + L-erythro-4-Hydroxyglutamate <-> L-Glutamate + D-4-Hydroxy-2-oxoglutarate
ATP + L-Glutamate + NH3 <-> ADP + Phosphate + L-Glutamine
ATP + L-Histidine + 4-Aminobutanoate <-> Diphosphate + AMP + Homocarnosine
O2 + cis-4-Hydroxy-D-proline <-> H2O2 + 1-Pyrroline-4-hydroxy-2-carboxylate
S-Adenosyl-L-methionine <-> CO2 + S-Adenosylmethioninamine
O2 + 2-Oxoglutarate + (Pro-Pro-Gly)5 <-> CO2 + Succinate + (Pro-4-hydroxy-Pro-Gly)5
2 ATP + NH3 + L-Ornithine + Hydrogencarbonate <-> 2 ADP + 2 Phosphate + H2O + L-Citrulline
Protein <-> L-Arginyl-tRNA(Arg)
ATP + L-Aspartate + L-Citrulline <-> Diphosphate + AMP + N(omega)-(L-Arginino)succinate
H2O + 1-Pyrroline-4-hydroxy-2-carboxylate <-> NH3 + 2,5-Dioxopentanoate
Carbamoyl phosphate + N2-Acetyl-L-ornithine <-> Phosphate + N-Acetyl-L-citrulline
Phosphate + NADP+ + N-Acetyl-L-glutamate 5-semialdehyde <-> H+ + NADPH + N-Acetyl-L-glutamyl 5-phosphate
L-Glutamate + N2-Acetyl-L-ornithine <-> L-Ornithine + N-Acetyl-L-glutamate
H2O + L-Proline + Acceptor <-> Reduced acceptor + (S)-1-Pyrroline-5-carboxylate
L-Ornithine <-> L-Proline + NH3
Carbamoyl phosphate + Putrescine <-> Phosphate + N-Carbamoylputrescine
Putrescine + Homospermidine <-> Putrescine + Homospermidine
L-Arginine + O2 <-> H2O + CO2 + 4-Guanidinobutanamide
H2O + 4-Guanidinobutanoate <-> Urea + 4-Aminobutanoate
L-Ornithine <-> L-Ornithine
L-Proline <-> D-Proline
FAD + trans-4-Hydroxy-L-proline <-> FADH2 + L-1-Pyrroline-3-hydroxy-5-carboxylate
H2O + Peptide <-> L-Proline + Peptide
Phosphate + NADP+ + L-Glutamate 5-semialdehyde <-> H+ + NADPH + L-Glutamyl 5-phosphate
H2O + 5'-Deoxy-5'-(methylthio)adenosine <-> Adenine + 5-Methylthio-D-ribose
H2O + L-Arginine <-> L-Ornithine + Urea
1-Pyrroline-4-hydroxy-2-carboxylate <-> H2O + Pyrrole-2-carboxylate
NAD+ + H2O + L-Glutamate 5-semialdehyde <-> NADH + H+ + L-Glutamate
NAD+ + H2O + N2-(1-Carboxyethyl)-L-arginine <-> Pyruvate + NADH + H+ + L-Arginine
ATP + L-Arginine + tRNA(Arg) <-> Diphosphate + AMP + L-Arginyl-tRNA(Arg)
Putrescine + Spermidine <-> 1,3-Diaminopropane + Homospermidine
 Classification
Amino Acid Metabolism
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