Pathway Details

 Recommended name Tyrosine metabolism
 Alternative names
 Reactions
O2 + L-Ascorbate + 4-(Trifluoromethyl)phenethylamine <-> H2O + Dehydroascorbate + 4-(Trifluoromethyl)phenylethanolamine
NAD+ + H2O + L-Tyrosine <-> NADH + H+ + NH3 + 3-(4-Hydroxyphenyl)pyruvate
H2O + O2 + 3-Methoxytyramine <-> NH3 + H2O2 + 3-Methoxy-4-hydroxyphenylacetaldehyde
S-Adenosyl-L-methionine + 3,4-Dihydroxymandelate <-> S-Adenosyl-L-homocysteine + 3-Methoxy-4-hydroxymandelate
NADH + H+ + O2 + 4-Hydroxyphenylacetate <-> NAD+ + H2O + 3,4-Dihydroxyphenylacetate
S-Adenosyl-L-methionine + L-Noradrenaline <-> S-Adenosyl-L-homocysteine + L-Adrenaline
H+ + NADPH + O2 + 4-Hydroxyphenylacetate <-> H2O + NADP+ + Homogentisate
L-Tyrosine <-> beta-Tyrosine
PQQ <-> Glutamate + Dopaquinone
O2 + Tyramine + N-(4-Methoxyphenyl)-N'-hydroxyguanidine <-> H2O + 1-(4-Hydroxyphenyl)-2-aminoethanol + N-(4-Methoxyphenyl)-N'-nitrosoimine
O2 + (S)-3-(4-Hydroxyphenyl)lactate <-> H2O2 + 3-(4-Hydroxyphenyl)pyruvate
4-Maleylacetoacetate <-> 4-Fumarylacetoacetate
O2 + 3-(4-Hydroxyphenyl)pyruvate <-> CO2 + Homogentisate
N-Hydroxy-L-tyrosine + Acceptor <-> CO2 + Reduced acceptor + Hydrogen + (Z)-4-Hydroxyphenylacetaldehyde-oxime
NAD+ + H2O + 3,4-Dihydroxyphenylacetaldehyde <-> NADH + H+ + 3,4-Dihydroxyphenylacetate
Pyruvate + Succinate semialdehyde <-> 4-Hydroxy-2-oxo-heptandioate
H2O2 + 2,5-Dihydroxybenzoate <-> H2O + O2 + Gentisate aldehyde
S-Adenosyl-L-methionine + 3,4-Dihydroxyphenylacetate <-> S-Adenosyl-L-homocysteine + Homovanillate
O2 + 2 L-Dopa <-> 2 H2O + 2 L-Dopaquinone
NAD+ + H2O + 3-Methoxy-4-hydroxyphenylacetaldehyde <-> NADH + H+ + Homovanillate
L-Dopa <-> CO2 + Dopamine
NADH + H+ + O2 + 4-Hydroxyphenylacetate <-> NAD+ + H2O + Homogentisate
NAD+ + H2O + 3,4-Dihydroxymandelaldehyde <-> NADH + H+ + 3,4-Dihydroxymandelate
O2 + L-Ascorbate + 2-Phenylethylamine <-> H2O + Phenylethanolamine + Dehydroascorbate
L-Glutamate + 4-Hydroxyphenylacetyl-CoA <-> Coenzyme A + 4-Hydroxyphenylacetylglutamine
3'-Phosphoadenylyl sulfate + Dopamine <-> Adenosine 3',5'-bisphosphate + Dopamine sulfate
NAD+ + H2O + 3-Methoxy-4-hydroxyphenylglycolaldehyde <-> NADH + H+ + 3-Methoxy-4-hydroxymandelate
H2O + O2 + L-Metanephrine <-> H2O2 + Methylamine + 3-Methoxy-4-hydroxyphenylglycolaldehyde
S-Adenosyl-L-methionine + Tyramine <-> S-Adenosyl-L-homocysteine + N-Methyltyramine
NADH + H+ + O2 + 3-Hydroxyphenylacetate <-> NAD+ + H2O + 3,4-Dihydroxyphenylacetate
Reduced acceptor + 3,3',5'-Triiodothyronine <-> H+ + I- + Acceptor + 3,3'-Diiodothyronine
H2O2 + p-Fluorophenol <-> H2O + 4-Fluorocatechol
D-Glucose + 4-Hydroxyphenylethanol <-> H2O + Salidroside
NADP+ + (R)-3-(4-Hydroxyphenyl)lactate <-> H+ + NADPH + 3-(4-Hydroxyphenyl)pyruvate
ATP + Coenzyme A + 4-Hydroxyphenylacetate <-> Diphosphate + AMP + 4-Hydroxyphenylacetyl-CoA
O2 + 2 5,6-Dihydroxyindole <-> 2 H2O + 2 Indole-5,6-quinone
4-Hydroxymandelonitrile + UDPglucose <-> UDP + Dhurrin
Acceptor + Dopaquinone <-> Reduced acceptor + 2-Carboxy-2,3-dihydro-5,6-dihydroxyindole
H2O + O2 + Dopamine <-> NH3 + H2O2 + 3,4-Dihydroxyphenylacetaldehyde
H+ + NADPH + Stizolobinate <-> NADP+ + 5-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde
H2O + L-Tyrosine <-> Pyruvate + NH3 + Phenol
Pyruvate + L-Tyrosine <-> L-Alanine + 3-(4-Hydroxyphenyl)pyruvate
S-Adenosyl-L-methionine + L-Noradrenaline <-> S-Adenosyl-L-homocysteine + L-Normetanephrine
5,6-Dihydroxyindole-2-carboxylate <-> Melanin
L-Tyrosine + O2 + Tetrahydrobiopterin <-> H2O + 6,7-Dihydrobiopterin + L-Dopa
H2O + O2 + Tyramine <-> NH3 + H2O2 + 4-Hydroxyphenylacetaldehyde
NAD+ + H2O + Succinate semialdehyde <-> NADH + H+ + Succinate
S-Adenosyl-L-methionine + 3,4-Dihydroxyphenylacetate <-> S-Adenosyl-L-homocysteine + 3-Methoxy-4-hydroxyphenylacetate
2 L-Tyrosine + O2 <-> 2 L-Dopa
NAD+ + (R)-3-(4-Hydroxyphenyl)lactate <-> NADH + H+ + 3-(4-Hydroxyphenyl)pyruvate
4-Hydroxyphenylacetonitrile <-> 4-Hydroxyphenylacetaldoxime
Caffeoyl-CoA + 3-(3,4-Dihydroxyphenyl)lactate <-> Coenzyme A + Rosmarinate
NAD+ + 3-(4-Hydroxyphenyl)lactate <-> NADH + H+ + 3-(4-Hydroxyphenyl)pyruvate
H+ + L-Tyrosine + NADPH + O2 <-> H2O + NADP+ + N-Hydroxy-L-tyrosine
S-Adenosyl-L-methionine + N-Methyltyramine <-> S-Adenosyl-L-homocysteine + Hordenine
H2O + NADP+ + 3-Methoxy-4-hydroxyphenylacetaldehyde <-> H+ + NADPH + Homovanillate
H2O2 + 3,5-Diiodo-L-tyrosine + 3-Iodo-L-tyrosine <-> 2 H2O + 2-Aminoacrylate + Triiodothyronine
5-Carboxymethyl-2-hydroxymuconate <-> 5-Carboxy-2-oxohept-3-enedioate
NADH + H+ + O2 + Tyramine <-> NAD+ + H2O + Dopamine
4-Hydroxymandelonitrile + UDPglucose <-> UDP + Taxiphyllin
H2O + NADP+ + Succinate semialdehyde <-> H+ + NADPH + Succinate
Pyruvate + Succinate semialdehyde <-> 2,4-Dihydroxyhept-2-enedioate
L-Dopachrome <-> CO2 + 5,6-Dihydroxyindole
2-Oxoglutarate + L-Dopa <-> L-Glutamate + 3-(3,4-Dihydroxyphenyl)pyruvate
Fumarate + Acetoacetate <-> H2O + 4-Fumarylacetoacetate
H2O + 2-Hydroxyhepta-2,4-dienedioate <-> 2,4-Dihydroxyhept-2-enedioate
2-Oxohept-3-enedioate <-> 2-Hydroxyhepta-2,4-dienedioate
H+ + NADPH + Stizolobate <-> NADP+ + 4-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde
H2O + 3-Fumarylpyruvate <-> Pyruvate + Fumarate
L-Tyrosine + O2 + L-Dopa <-> H2O + L-Dopa + Dopaquinone
H2O + NADP+ + 3,4-Dihydroxyphenylacetaldehyde <-> H+ + NADPH + 3,4-Dihydroxyphenylacetate
O2 + L-Ascorbate + 3,4-Dihydroxyphenethylamine <-> H2O + L-Noradrenaline + Dehydroascorbate
O2 + 2 L-Dopa <-> 2 H2O + 2 Dopaquinone
H2O + 2-Hydroxyhepta-2,4-dienedioate <-> 4-Hydroxy-2-ketopimelate
H2O + NADP+ + 3,4-Dihydroxymandelaldehyde <-> H+ + NADPH + 3,4-Dihydroxymandelate
L-Tyrosine + O2 <-> H2O + L-Dopa
H2O + O2 + L-Noradrenaline <-> NH3 + H2O2 + 3,4-Dihydroxymandelaldehyde
H2O + O2 + L-Normetanephrine <-> NH3 + H2O2 + 3-Methoxy-4-hydroxyphenylglycolaldehyde
S-Adenosyl-L-methionine + Dopamine <-> S-Adenosyl-L-homocysteine + 3-Methoxytyramine
O2 + 3,4-Dihydroxyphenylacetate <-> 2-Hydroxy-5-carboxymethylmuconate semialdehyde
NAD+ + 4-Hydroxyphenylethanol <-> NADH + H+ + 4-Hydroxyphenylacetaldehyde
O2 + L-Ascorbate + Tyramine <-> H2O + Dehydroascorbate + 1-(4-Hydroxyphenyl)-2-aminoethanol
3,5-Diiodo-L-tyrosine + HI <-> 3-Iodo-L-tyrosine + Iodine
L-Tyrosine <-> NH3 + 4-Coumarate
NADP+ + 3-(4-Hydroxyphenyl)lactate <-> H+ + NADPH + 3-(4-Hydroxyphenyl)pyruvate
H2O2 + 2 3,5-Diiodo-L-tyrosine <-> 2 H2O + L-Thyroxine + 2-Aminoacrylate
H+ + NADPH + O2 + 4-Hydroxyphenylacetonitrile <-> H2O + NADP+ + 4-Hydroxymandelonitrile
NAD+ + 3,4-Dihydroxyphenylethyleneglycol <-> NADH + H+ + 3,4-Dihydroxymandelaldehyde
NAD+ + 3-(3,4-Dihydroxyphenyl)lactate <-> NADH + H+ + 3-(3,4-Dihydroxyphenyl)pyruvate
5-Carboxy-2-oxohept-3-enedioate <-> CO2 + 2-Hydroxyhepta-2,4-dienedioate
O2 + L-Ascorbate + Dopamine <-> H2O + L-Noradrenaline + Dehydroascorbate
O2 + L-Dopa <-> 5-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde
3-(4-Hydroxyphenyl)pyruvate <-> CO2 + 4-Hydroxyphenylacetaldehyde
O2 + Homogentisate <-> H2O + CO2 + Gentisate aldehyde
L-Tyrosine + 2-Oxoglutarate <-> L-Glutamate + 3-(4-Hydroxyphenyl)pyruvate
H2O + 2-Oxohept-3-enedioate <-> 4-Hydroxy-2-oxo-heptandioate
NADH + H+ + Stizolobate <-> NAD+ + 4-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde
3-Iodo-L-tyrosine + HI <-> L-Tyrosine + Iodine
Glycine + 4-Hydroxyphenylacetyl-CoA <-> Coenzyme A + 4-Hydroxyphenylacetylglycine
H2O + 2-Oxohept-3-enedioate <-> 2,4-Dihydroxyhept-2-enedioate
H2O + L-Tyrosine + O2 <-> NH3 + H2O2 + 3-(4-Hydroxyphenyl)pyruvate
O2 + 2 3-(4-Hydroxyphenyl)pyruvate <-> 2 CO2 + 2 4-Hydroxyphenylacetate
L-Dopa + L-Dopachrome <-> Dopaquinone + 2-Carboxy-2,3-dihydro-5,6-dihydroxyindole
O2 + Indole-5,6-quinone <-> H2O + Melanin
3-Maleylpyruvate <-> 3-Fumarylpyruvate
L-Tyrosine <-> CO2 + Tyramine
H2O2 + Methylparaben <-> H2O + Methyl 3,4-dihydroxybenzoate
S-Adenosyl-L-methionine + L-Adrenaline <-> S-Adenosyl-L-homocysteine + L-Metanephrine
NAD+ + H2O + Gentisate aldehyde <-> NADH + H+ + 2,5-Dihydroxybenzoate
2 H2O2 <-> 2 H2O + O2
O2 + 2,5-Dihydroxybenzoate <-> 3-Maleylpyruvate
2,5-Dihydroxybenzoate <-> CO2 + Hydroquinone
NAD+ + H2O + 3,4-Dihydroxyphenylglycolaldehyde <-> NADH + H+ + 3,4-Dihydroxyphenylglycolate
NAD+ + H2O + 2-Hydroxy-5-carboxymethylmuconate semialdehyde <-> NADH + H+ + 5-Carboxymethyl-2-hydroxymuconate
H2O + NADP+ + 3-Methoxy-4-hydroxyphenylglycolaldehyde <-> H+ + NADPH + 3-Methoxy-4-hydroxymandelate
UDPglucose + (S)-4-Hydroxymandelonitrile <-> UDP + Dhurrin
O2 + Tyramine + N-(4-Chlorophenyl)-N'-hydroxyguanidine <-> H2O + 1-(4-Hydroxyphenyl)-2-aminoethanol + N-(4-Chlorophenyl)-N'-nitrosoimine
O2 + L-Dopa <-> 4-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde
H2O2 + 4-Cresol <-> H2O + 4-Methylcatechol
O2 + Homogentisate <-> 4-Maleylacetoacetate
N-Hydroxy-L-tyrosine + Acceptor <-> CO2 + Reduced acceptor + Hydrogen + 4-Hydroxyphenylacetaldoxime
NADH + H+ + Stizolobinate <-> NAD+ + 5-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde
NAD+ + H2O + 4-Hydroxyphenylacetaldehyde <-> NADH + H+ + 4-Hydroxyphenylacetate
Pyruvate + Succinate semialdehyde <-> 4-Hydroxy-2-ketopimelate
H2O + NADP+ + 2-Hydroxy-5-carboxymethylmuconate semialdehyde <-> H+ + NADPH + 5-Carboxymethyl-2-hydroxymuconate
CO2 + 5,6-Dihydroxyindole <-> 2-Carboxy-2,3-dihydro-5,6-dihydroxyindole
H2O + NADP+ + 4-Hydroxyphenylacetaldehyde <-> H+ + NADPH + 4-Hydroxyphenylacetate
H2O + O2 + L-Adrenaline <-> H2O2 + Methylamine + 3,4-Dihydroxymandelaldehyde
L-Dopa <-> NH3 + 3,4-Dihydroxy-trans-cinnamate
3-(4-Hydroxyphenyl)pyruvate <-> 4-Hydroxy-enol-phenylpyruvate
H2O2 + 4-Chlorophenol <-> H2O + 4-Chlorocatechol
L-Dopachrome <-> 5,6-Dihydroxyindole-2-carboxylate
S-Adenosyl-L-methionine + 3,4-Dihydroxyphenylethyleneglycol <-> S-Adenosyl-L-homocysteine + 3-Methoxy-4-hydroxyphenylethyleneglycol
H2O2 + p-Bromophenol <-> H2O + 4-Bromocatechol
 Classification
Amino Acid Metabolism
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