Pathway Details

 Recommended name Porphyrin and chlorophyll metabolism
 Alternative names
 Reactions
Oxidized ferredoxin + (3Z)-Phytochromobilin <-> Reduced ferredoxin + Biliverdin
3 O2 + 2 Protoporphyrinogen IX <-> 6 H2O + 2 Protoporphyrin
Transferrin[Fe(II)]2 <-> Fe2+ + Apotransferrin
6 H+ + 2 H2O + Bilirubin beta-diglucuronide <-> 2 D-Glucuronate + D-Urobilinogen
H+ + NADPH + Cobalt-precorrin 6 <-> NADP+ + Cobalt-dihydro-precorrin 6
Phytyl diphosphate + Chlorophyllide a <-> Diphosphate + Bacterio-chlorophylls
4 ATP + 4 L-Glutamine + Adenosyl cobyrinate a,c diamide <-> 4 ADP + 4 Phosphate + 4 L-Glutamate + Adenosyl cobyrinate hexaamide
S-Adenosyl-L-methionine + Cobalt-precorrin 2 <-> S-Adenosyl-L-homocysteine + Cobalt-precorrin 3
S-Adenosyl-L-methionine + Precorrin 4 <-> S-Adenosyl-L-homocysteine + Precorrin 5
3 O2 + FADH2 + Hemoglobin <-> 3 H2O + FAD + Fe2+ + Carbon monoxide + Biliverdin + Globin
H+ + NADPH + Divinyl chlorophyllide a <-> NADP+ + Chlorophyllide a
NAD+ + Precorrin 2 <-> NADH + H+ + Sirohydrochlorin
Myoglobin <-> Heme + Globin
NAD+ + Bilirubin <-> NADH + H+ + Biliverdin
5-Aminolevulinate <-> (S)-4-Amino-5-oxopentanoate
NADP+ + Divinyl chlorophyllide a <-> H+ + NADPH + Divinylprotochlorophyllide
3 O2 + FADH2 + Hemoglobin <-> 3 H2O + FAD + Fe3+ + Carbon monoxide + Biliverdin + Globin
4 H+ + I-Urobilinogen <-> L-Urobilinogen
GTP + Adenosyl cobinamide <-> GDP + Adenosyl cobinamide phosphate
ATP + H2O + Mg2+ + Protoporphyrin <-> ADP + Phosphate + 2 H+ + Magnesium protoporphyrin
Reduced acceptor + Uroporphyrinogen I <-> 6 H+ + Acceptor + Uroporphyrin I
2 5-Aminolevulinate <-> 2 H2O + Porphobilinogen
Acceptor + (3Z)-Phycocyanobilin <-> 2 H+ + Reduced acceptor + (3Z)-Phytochromobilin
H+ + NADPH + 2 Aquacob(III)alamin <-> 2 H2O + NADP+ + 2 Cob(II)alamin
2 H+ + Siroheme <-> Fe2+ + Sirohydrochlorin
ATP + D-1-Aminopropan-2-ol O-phosphate + Adenosyl cobyrinate hexaamide <-> ADP + Phosphate + Adenosyl cobinamide phosphate
2 UDPglucuronate + Bilirubin <-> 2 UDP + Bilirubin beta-diglucuronide
2 ATP + 2 H2O + 2 L-Glutamine + Hydrogenobyrinate <-> 2 ADP + 2 Phosphate + 2 L-Glutamate + Hydrogenobyrinate a,c diamide
1-Aminopropan-2-ol + Adenosyl cobyrinate hexaamide <-> Adenosyl cobinamide
O2 + Precorrin 3A <-> Precorrin 3B
H+ + NADPH + O2 + 13(1)-Oxo-magnesium-protoporphyrin IX 13-monomethyl ester <-> 2 H2O + NADP+ + Divinylprotochlorophyllide
GMP + Coenzyme B12 <-> Adenosine-GDP-cobinamide + alpha-Ribazole
Hydroxymethylbilane <-> H2O + Uroporphyrinogen III
H+ + NADPH + O2 + 13(1)-Hydroxy-magnesium-protoporphyrin IX 13-monomethyl ester <-> 2 H2O + NADP+ + 13(1)-Oxo-magnesium-protoporphyrin IX 13-monomethyl ester
ATP + Adenosyl cobinamide <-> ADP + Adenosyl cobinamide phosphate
Divinylchlorophyll a <-> Chlorophyll a
L-Threonine O-3-phosphate <-> CO2 + D-1-Aminopropan-2-ol O-phosphate
H+ + NADPH + L-Glutamyl-tRNA(Glu) <-> NADP+ + tRNA(Glu) + (S)-4-Amino-5-oxopentanoate
Acceptor + Coproporphyrinogen III <-> 6 H+ + Reduced acceptor + Coproporphyrin III
(R)-1-Aminopropan-2-ol + Adenosyl cobyrinate hexaamide <-> H2O + Adenosyl cobinamide
2 S-Adenosyl-L-methionine + Coproporphyrinogen III <-> 2 L-Methionine + 2 CO2 + 2 5'-Deoxyadenosine + Protoporphyrinogen IX
H+ + NADPH + L-Glutamyl-tRNA(Glu) <-> H2O + NADP+ + tRNA(Glu) + (S)-4-Amino-5-oxopentanoate
2 H+ + D-Urobilinogen <-> I-Urobilinogen
O2 + 2 D-Urobilinogen <-> 2 H2O + 2 D-Urobilin
O2 + Coproporphyrinogen III <-> 2 H2O + 2 CO2 + Protoporphyrinogen IX
NADP+ + Chlorophyllide a <-> H+ + NADPH + Protochlorophyllide
2 S-Adenosyl-L-methionine + Precorrin 6Y <-> CO2 + 2 S-Adenosyl-L-homocysteine + Precorrin 8X
Phytyl diphosphate + Chlorophyllide a <-> Diphosphate + Mg2+ + Bacterio-pheophytins
13(1)-Oxo-magnesium-protoporphyrin IX 13-monomethyl ester <-> 2 H+ + Divinylprotochlorophyllide
H2O + Magnesium protoporphyrin monomethyl ester <-> 13(1)-Hydroxy-magnesium-protoporphyrin IX 13-monomethyl ester
Co2+ + ATP + Hydrogenobyrinate a,c diamide <-> ADP + Phosphate + Cob(II)yrinate a,c diamide
O2 + 2 I-Urobilinogen <-> 2 H2O + 2 I-Urobilin
S-Adenosyl-L-methionine + Precorrin 3B <-> S-Adenosyl-L-homocysteine + Precorrin 4
Heme <-> Catalase
Precorrin 8X <-> Hydrogenobyrinate
Hydroxymethylbilane <-> H2O + Uroporphyrinogen I
S-Adenosyl-L-methionine + Magnesium protoporphyrin <-> S-Adenosyl-L-homocysteine + Magnesium protoporphyrin monomethyl ester
Reduced ferredoxin + 15,16-Dihydrobiliverdin <-> Oxidized ferredoxin + (3Z)-Phycoerythrobilin
Heme <-> Peroxidase
O2 + 2 L-Urobilinogen <-> 2 H2O + 2 L-Urobilin
ATP + Cob(I)alamin <-> Triphosphate + Coenzyme B12
Heme <-> Cytochrome a
H2O + N1-(5-Phospho-alpha-D-ribosyl)-5,6-dimethylbenzimidazole <-> Phosphate + alpha-Ribazole
S-Adenosyl-L-methionine + Precorrin 2 <-> S-Adenosyl-L-homocysteine + Precorrin 3A
NAD+ + 2 Cob(I)alamin <-> NADH + H+ + 2 Cob(II)alamin
2 ATP + 2 H2O + 2 L-Glutamine + Cobyrinate <-> 2 ADP + 2 Phosphate + 2 L-Glutamate + Cob(II)yrinate a,c diamide
Holocytochrome c <-> Heme + Apocytochrome c
H2O + 4 Porphobilinogen <-> 4 NH3 + Hydroxymethylbilane
O2 + Hemoglobin <-> Oxyhemoglobin
Uroporphyrinogen I <-> 4 CO2 + Coproporphyrinogen I
2 S-Adenosyl-L-methionine + Uroporphyrinogen III <-> 2 S-Adenosyl-L-homocysteine + Precorrin 2
H2O + S-Adenosyl-L-methionine + Cobalt-precorrin 5 <-> S-Adenosyl-L-homocysteine + Acetaldehyde + Cobalt-precorrin 6
Cobalt-precorrin 8 <-> Cobyrinate
4 H+ + O2 + 4 Fe2+ <-> 2 H2O + 4 Fe3+
2 S-Adenosyl-L-methionine + Cobalt-dihydro-precorrin 6 <-> CO2 + 2 S-Adenosyl-L-homocysteine + Cobalt-precorrin 8
Ni2+ + Precorrin 2 <-> Coenzyme F430
Acceptor + Uroporphyrinogen III <-> 6 H+ + Reduced acceptor + Uroporphyrin III
NADH + H+ + Cob(II)yrinate a,c diamide <-> NAD+ + Cob(I)yrinate a,c diamide
Pyruvate + 5-Aminolevulinate <-> L-Alanine + 4,5-Dioxopentanoate
13(1)-Hydroxy-magnesium-protoporphyrin IX 13-monomethyl ester <-> 2 H+ + 13(1)-Oxo-magnesium-protoporphyrin IX 13-monomethyl ester
ATP + Protochlorophyllide <-> ADP + Phosphate + Chlorophyllide a
Reduced ferredoxin + Biliverdin <-> Oxidized ferredoxin + (3Z)-Phycocyanobilin
Uroporphyrinogen III <-> 4 CO2 + Coproporphyrinogen III
S-Adenosyl-L-methionine + Cobalt-precorrin 3 <-> S-Adenosyl-L-homocysteine + Cobalt-precorrin 4
Hemoglobin <-> Heme + Globin
Fe2+ + Protoporphyrin <-> 2 H+ + Heme
Acceptor + Coproporphyrinogen I <-> 6 H+ + Reduced acceptor + Coproporphyrin I
H+ + NADPH + O2 + Magnesium protoporphyrin monomethyl ester <-> H2O + NADP+ + 13(1)-Hydroxy-magnesium-protoporphyrin IX 13-monomethyl ester
NADP+ + Precorrin 6Y <-> H+ + NADPH + Precorrin 6X
H2O + Chlorophyll a <-> Phytol + Chlorophyllide a
Reduced ferredoxin + Biliverdin <-> Oxidized ferredoxin + 15,16-Dihydrobiliverdin
NAD+ + Transferrin[Fe(II)]2 <-> NADH + H+ + Transferrin[Fe(III)]2
ATP + (R)-1-Aminopropan-2-ol + Adenosyl cobyrinate hexaamide <-> ADP + Phosphate + Adenosyl cobinamide
4 ATP + 4 H2O + 4 L-Glutamine + Adenosyl cobyrinate a,c diamide <-> 4 ADP + 4 Phosphate + 4 L-Glutamate + Adenosyl cobyrinate hexaamide
2 H+ + Divinylprotochlorophyllide <-> Protochlorophyllide
Heme <-> Heme O
Transferrin[Fe(III)]2 <-> Fe3+ + Apoferritin
2 H+ + Acceptor + (3Z)-Phycocyanobilin <-> 2 H+ + Reduced acceptor + (3Z)-Phycoerythrobilin
Glycine + Succinyl-CoA <-> Coenzyme A + CO2 + 5-Aminolevulinate
S-Adenosyl-L-homocysteine + Acetate + Precorrin 6X <-> H2O + S-Adenosyl-L-methionine + Precorrin 5
NAD+ + 2 H2O + 2 Cob(II)alamin <-> NADH + H+ + 2 Aquacob(III)alamin
Co2+ + Sirohydrochlorin <-> Cobalt-precorrin 2
Heme O <-> Heme A
Cytochrome c <-> Heme + Apocytochrome c
NADP+ + Cyanide + Cob(I)alamin <-> H+ + NADPH + Cyanocob(III)alamin
ATP + Cobinamide <-> Triphosphate + Adenosyl cobinamide
S-Adenosyl-L-methionine + Cobalt-precorrin 4 <-> S-Adenosyl-L-homocysteine + Cobalt-precorrin 5
L-Threonine <-> L-Threonine O-3-phosphate
ATP + Cob(I)yrinate a,c diamide <-> Triphosphate + Adenosyl cobyrinate a,c diamide
Divinyl chlorophyllide a <-> Divinylchlorophyll a
ATP + L-Glutamate + tRNA(Glu) <-> Diphosphate + AMP + L-Glutamyl-tRNA(Glu)
ATP + Cob(I)yrinate a,c diamide <-> Phosphate + Diphosphate + Adenosyl cobyrinate a,c diamide
O2 + 2 Bilirubin <-> 2 H2O + 2 Biliverdin
NADP+ + Bilirubin <-> H+ + NADPH + Biliverdin
GTP + Adenosyl cobinamide phosphate <-> Diphosphate + Adenosine-GDP-cobinamide
Nicotinate D-ribonucleotide + Dimethylbenzimidazole <-> Nicotinate + N1-(5-Phospho-alpha-D-ribosyl)-5,6-dimethylbenzimidazole
Phytyl diphosphate + Chlorophyllide a <-> Diphosphate + Chlorophyll a
 Classification
Metabolism of Cofactors and Vitamins
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