Enzyme Details

EC Classification

6.3.2.8

Enzyme name
(recommended)

UDP-N-acetylmuramate---L-alanine ligase

Alternative names

UDP-N-acetylmuramate:L-alanine ligase (ADP-forming)
MurC synthetase
UDP-N-acetylmuramoyl-L-alanine synthetase
uridine diphospho-N-acetylmuramoylalanine synthetase
UDP-N-acetylmuramoylalanine synthetase
L-alanine-adding enzyme
UDP-acetylmuramyl-L-alanine synthetase
UDPMurNAc-L-alanine synthetase
L-Ala ligase
uridine diphosphate N-acetylmuramate:L-alanine ligase
uridine 5'-diphosphate-N-acetylmuramyl-L-alanine synthetase
uridine-diphosphate-N-acetylmuramate:L-alanine ligase
UDP-MurNAc:L-alanine ligase
alanine-adding enzyme
UDP-N-acetylmuramyl:L-alanine ligase

Classification

Ligases

Forming carbon-nitrogen bonds

Acid--amino-acid ligases (peptide synthases)

Catalyses reactions

ATP + L-Alanine + UDP-N-acetylmuramate <-> ADP + Phosphate + UDP-N-acetylmuramoyl-L-alanine

ATP + L-Serine + UDP-N-acetylmuramate <-> ADP + Phosphate + UDP-N-acetylmuramoyl-L-serine

ATP + Glycine + UDP-N-acetylmuramate <-> ADP + Phosphate + UDP-N-acetylmuramoyl-glycine

ATP + UDP-N-acetylmuramate + 3-Chloro-L-alanine <-> ADP + Phosphate + UDP-N-acetylmuramoyl-L-3-chloro-L-alanine

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 6.3.2.8