Enzyme Details

EC Classification

6.3.2.11

Enzyme name
(recommended)

carnosine synthase

Alternative names

L-histidine:beta-alanine ligase (ADP-forming)
carnosine synthetase
carnosine-anserine synthetase
homocarnosine-carnosine synthetase
carnosine-homocarnosine synthetase
L-histidine:beta-alanine ligase (AMP-forming) (incorrect)

Classification

Ligases

Forming carbon-nitrogen bonds

Acid--amino-acid ligases (peptide synthases)

Catalyses reactions

ATP + L-Lysine + beta-Alanine <-> Diphosphate + AMP + beta-Alanyl-L-lysine

ATP + L-Arginine + beta-Alanine <-> Diphosphate + AMP + beta-Alanyl-L-arginine

ATP + L-Histidine + beta-Alanine <-> Diphosphate + AMP + Carnosine

ATP + L-Histidine + 4-Aminobutanoate <-> Diphosphate + AMP + Homocarnosine

ATP + beta-Alanine + N(pai)-Methyl-L-histidine <-> H2O + Diphosphate + AMP + beta-Alanyl-N(pai)-methyl-L-histidine

ATP + beta-Alanine + N(pai)-Methyl-L-histidine <-> Diphosphate + AMP + beta-Alanyl-N(pai)-methyl-L-histidine

ATP + L-Histidine + beta-Alanine <-> ADP + Phosphate + Carnosine

ATP + L-Histidine + 4-Aminobutanoate <-> ADP + Phosphate + Homocarnosine

ATP + L-Lysine + beta-Alanine <-> ADP + Phosphate + beta-Alanyl-L-lysine

ATP + L-Ornithine + beta-Alanine <-> ADP + Phosphate + beta-Alanyl-L-ornithine

ATP + beta-Alanine + N(pai)-Methyl-L-histidine <-> ADP + Phosphate + beta-Alanyl-N(pai)-methyl-L-histidine

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 6.3.2.11