Enzyme Details
EC Classification
6.3.1.9
Enzyme name
(recommended)
trypanothione synthase
Alternative names
glutathionylspermidine:glutathione ligase (ADP-forming)
Classification
Ligases
Forming carbon-nitrogen bonds
Acid-D-ammonia (or amine) ligases (amide synthases)
Catalyses reactions
ATP + Reduced glutathione + Glutathionylspermidine <-> ADP + Phosphate + Reduced trypanothione
ATP + Reduced glutathione + Spermidine <-> ADP + Phosphate + Glutathionylspermidine
Reduced glutathione + Enzyme-Glutathione-Phosphate-Spermidine complex <-> Enzyme-Glutathione-Phosphate-Spermidine-Glutathione-complex
Reduced trypanothione + Enzyme-Glutathione-Phosphate-Spermidine complex <-> Enzyme-Glutathione-Phosphate-Spermidine-Trypanothione complex
ADP <-> pool
Spermidine <-> Enzyme-Spermidine complex
ATP + Enzyme-Glutathione-Glutathionylspermidine complex <-> Enzyme-ATP-Glutathione-Glutathionylspermidine complex
Enzyme-ATP-Glutathione-Glutathionylspermidine complex <-> ADP + Enzyme-Glutathione-Phosphate-Glutathionylspermidine complex
Reduced glutathione + Enzyme-ATP-Glutathionylspermidine complex <-> Enzyme-ATP-Glutathione-Glutathionylspermidine complex
Reduced glutathione + Enzyme-Glutathionylspermidine complex <-> Enzyme-Glutathione-Glutathionylspermidine complex
Reduced glutathione + Enzyme-Glutathione-Phosphate-Glutathionylspermidine complex <-> Enzyme-Glutathione-Phosphate-Glutathionylspermidine-Glutathione complex
Reduced trypanothione + Enzyme-Glutathione-Phosphate-Glutathionylspermidine complex <-> Enzyme-Glutathione-Phosphate-Glutathionylspermidine-Trypanothione complex
Enzyme-Glutathione-Phosphate-Glutathionylspermidine complex <-> Enzyme-Trypanothione complex
Enzyme-Trypanothione complex <-> Reduced trypanothione
ATP + Enzyme-Glutathione-Spermidine complex <-> Enzyme-ATP-Glutathione-Spermidine complex
Reduced glutathione + Enzyme-Spermidine complex <-> Enzyme-Glutathione-Spermidine complex
Reduced glutathione + Enzyme-ATP-Spermidine complex <-> Enzyme-ATP-Glutathione-Spermidine complex
ATP + Enzyme-Spermidine complex <-> Enzyme-ATP-Spermidine complex
Enzyme-ATP-Glutathione-Spermidine complex <-> ADP + Enzyme-Glutathione-Phosphate-Spermidine complex
Spermidine + Enzyme-ATP-Glutathione complex <-> Enzyme-ATP-Glutathione-Spermidine complex
Spermidine + Enzyme-Glutathione complex <-> Enzyme-Glutathione-Spermidine complex
Spermidine + Enzyme-ATP complex <-> Enzyme-ATP-Spermidine complex
Enzyme-Glutathionylspermidine complex <-> Glutathionylspermidine
Enzyme-Glutathione-Phosphate-Spermidine complex <-> Enzyme-Glutathionylspermidine complex
ATP <-> Enzyme-ATP complex
Reduced glutathione + Enzyme-ATP complex <-> Enzyme-ATP-Glutathione complex
Reduced glutathione <-> Enzyme-Glutathione complex
ATP + Enzyme-Glutathione complex <-> Enzyme-ATP-Glutathione complex
Glutathionylspermidine + Enzyme-ATP-Glutathione complex <-> Enzyme-ATP-Glutathione-Glutathionylspermidine complex
Glutathionylspermidine + Enzyme-ATP complex <-> Enzyme-ATP-Glutathionylspermidine complex
Glutathionylspermidine + Enzyme-Glutathione complex <-> Enzyme-Glutathione-Glutathionylspermidine complex
ATP + Enzyme-Glutathionylspermidine complex <-> Enzyme-ATP-Glutathionylspermidine complex
External links
Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop
View all entries for EC Class:
6.3.1.9
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