Enzyme Details

 EC Classification 6.2.1.12
 Enzyme name
(recommended)		 4-coumarate---CoA ligase
 Alternative names 4-coumarate:CoA ligase (AMP-forming)
4-coumaroyl-CoA synthetase
p-coumaroyl CoA ligase
p-coumaryl coenzyme A synthetase
p-coumaryl-CoA synthetase
p-coumaryl-CoA ligase
feruloyl CoA ligase
hydroxycinnamoyl CoA synthetase
4-coumarate:coenzyme A ligase
caffeolyl coenzyme A synthetase
p-hydroxycinnamoyl coenzyme A synthetase
feruloyl coenzyme A synthetase
sinapoyl coenzyme A synthetase
4-coumaryl-CoA synthetase
hydroxycinnamate:CoA ligase
p-coumaryl-CoA ligase
p-hydroxycinnamic acid:CoA ligase
4CL
 Classification
Ligases
Forming carbon-sulfur bonds
Acid--thiol ligases
 Catalyses reactions
ATP + Coenzyme A + 4-Coumarate <-> Diphosphate + AMP + 4-Coumaroyl-CoA
ATP + Coenzyme A + 3,4-Dihydroxy-trans-cinnamate <-> Diphosphate + AMP + Caffeoyl-CoA
ATP + Coenzyme A + Ferulate <-> Diphosphate + AMP + Feruloyl-CoA
ATP + Coenzyme A + Sinapate <-> Diphosphate + AMP + Sinapoyl-CoA
ATP + Coenzyme A + trans-Cinnamate <-> Diphosphate + AMP + Cinnamoyl-CoA
ATP + Coenzyme A + 5-Hydroxyferulate <-> Diphosphate + AMP + 5-Hydroxyferuloyl-CoA
ATP + Coenzyme A + Cinnamic acid <-> Diphosphate + AMP + Cinnamoyl-CoA
ATP + Coenzyme A + 2-Coumarate <-> Diphosphate + AMP + 2-Coumaroyl-CoA
ATP + Coenzyme A + trans-3-Hydroxycinnamate <-> Diphosphate + AMP + 3-Coumaroyl-CoA
ATP + Coenzyme A + Caffeate <-> Diphosphate + AMP + Caffeoyl-CoA
ATP + Coenzyme A + Isoferulic acid <-> Diphosphate + AMP + Isoferuloyl-CoA
ATP + Coenzyme A + 4-Methoxycinnamate <-> Diphosphate + AMP + 4-Methoxycinnamoyl-CoA
ATP + Coenzyme A + 3,4-Dimethoxycinnamic acid <-> Diphosphate + AMP + 3,4-Dimethoxycinnamoyl-CoA
ATP + Triphosphate <-> Diphosphate + Adenosine 5'-tetraphosphate
Triphosphate + P1,P4-Bis(5'-adenosyl) tetraphosphate <-> ATP + Adenosine 5'-tetraphosphate
 External links Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop


View all entries for EC Class: 6.2.1.12



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