Enzyme Details

EC Classification

5.3.99.4

Enzyme name
(recommended)

prostaglandin-I synthase

Alternative names

(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate 6-isomerase
prostacyclin synthase
prostacycline synthetase
prostagladin I2 synthetase
PGI2 synthase
PGI2 synthetase

Classification

Isomerases

Intramolecular oxidoreductases

Other intramolecular oxidoreductases

Catalyses reactions

Prostaglandin H2 <-> Prostaglandin I2

Prostaglandin H1 <-> Malondialdehyde + 12-Hydroxy-8,10-heptadecadienoic acid

Prostaglandin H2 <-> Prostaglandin D2

Carbon monoxide + reduced PGIS <-> Enzyme-ligand complex

10-Hydroperoxyoctadeca-8,12-dienoic acid <-> Unknown + 10-Oxodec-8-enoic acid

Imidazole + PGIS <-> Enzyme-ligand complex

PGIS + 4-Phenylimidazole <-> Enzyme-ligand complex

1-Phenylimidazole + PGIS <-> Enzyme-ligand complex

PGIS + 1-Benzylimidazole <-> Enzyme-ligand complex

Clotrimazole + PGIS <-> Enzyme-ligand complex

Minoxidil + PGIS <-> Enzyme-ligand complex

Prostaglandin H2 + PGIS <-> Enzyme-ligand complex

PGIS + Sodium cyanide <-> Enzyme-ligand complex

Pyridine + PGIS <-> Enzyme-ligand complex

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 5.3.99.4