Enzyme Details

EC Classification

4.4.1.5

Enzyme name
(recommended)

lactoylglutathione lyase

Alternative names

(R)-S-lactoylglutathione methylglyoxal-lyase (isomerizing; glutathione-forming)
methylglyoxalase
aldoketomutase
ketone-aldehyde mutase
glyoxylase I
(R)-S-lactoylglutathione methylglyoxal-lyase (isomerizing)

Classification

Lyases

Carbon-sulfur lyases

Catalyses reactions

(R)-S-Lactoylglutathione <-> Reduced glutathione + Methylglyoxal

Reduced glutathione + Phenylglyoxal <-> S-Mandelylglutathione

Glutathione-methylglyoxal hemithioacetal <-> (R)-S-Lactoylglutathione

Glutathione isopropyl ester-methylglyoxal hemithioacetal <-> S-Lactoylglutathionyl isopropyl ester

N1-Glutathionylspermidine-methylglyoxal hemithioacetal <-> S-Lactoylglutathionylspermidine

Glutathione ethyl ester-methylglyoxal hemithioacetal <-> S-Lactoylglutathionyl ethyl ester

Trypanothione-methylglyoxal hemithioacetal <-> (R)-S-Lactoyltrypanothione

Reduced glutathione + 4-Phenylphenylglyoxal <-> 4-Phenyl-S-mandelylglutathione

Homoglutathione-phenylglyoxal hemithioacetal <-> S-Mandelylhomoglutathione

Reduced glutathione + p-Chlorophenylglyoxal <-> p-Chloro-S-mandelylglutathione

Glutathione-phenylglyoxal hemithioacetal <-> S-Mandelylglutathione

Glutathione-phenylglyoxal hemithioacetal <-> (R)-S-Mandeloylglutathione

Homoglutathione-methylglyoxal hemithioacetal <-> (R)-S-Lactoylhomoglutathione

Reduced glutathione + 2,4,6-Trimethylphenylglyoxal <-> 2,4,6-Trimethyl-S-mandelylglutathione

Glutamylcysteine-phenylglyoxal hemithioacetal <-> S-Mandelylglutamylcysteine

Glutamylcysteine-methylglyoxal hemithioacetal <-> S-Lactoyl-glutamylcysteine

Glutathionylspermidine-phenylglyoxal hemithioacetal <-> S-Mandelylglutathionylspermidine

Trypanothione-phenylglyoxal hemithioacetal <-> (R)-S-Mandelyltrypanothione

Reduced glutathione + 2,4-Dimethylphenylglyoxal <-> 2,4-Dimethyl-S-mandelylglutathione

Reduced glutathione + 3-Methoxyphenylglyoxal <-> 3-Methoxy-S-mandelylglutathione

Reduced glutathione + 4-Methoxyphenylglyoxal <-> 4-Methoxy-S-mandelylglutathione

Reduced glutathione + 4-Methylphenylglyoxal <-> 4-Methyl-S-mandelylglutathione

Reduced glutathione + 4-Bromophenylglyoxal <-> 4-Bromo-S-mandelylglutathione

Reduced glutathione + p-Hydroxyphenylglyoxal <-> p-Hydroxy-S-mandelylglutathione

Reduced glutathione + Kethoxal <-> 3-Ethoxy-2-hydroxybutanoylglutathione

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 4.4.1.5