Enzyme Details

EC Classification

3.4.24.18

Enzyme name
(recommended)

meprin A

Alternative names

endopeptidase-2
meprin-a
meprin
N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase
PABA-peptide hydrolase
PPH

Classification

Hydrolases

Acting on peptide bonds (peptide hydrolases)

Metalloendopeptidases

Catalyses reactions

H2O + Phe5(4-nitro)bradykinin <-> Ser-Pro-Phe-Arg + Arg-Pro-Pro-Gly-Phe(NO2)

H2O + alpha-Melanotropin <-> Lys-Pro-Val + Met-Glu-His-Phe-Arg-Trp-Gly + Acetyl-Ser-Tyr-Ser

H2O + Neurotensin <-> L-Asparagine + Lys-Pro-Arg-Pro-Tyr-Ile-Leu-NH2 + pyroGlu-Leu-Tyr-Glu

H2O + Luteinizing hormone-releasing hormone <-> L-Serine + Tyr-Gly + Leu-Arg-Pro-Gly + Glu-His-Trp

H2O + Angiotensin I <-> L-Leucine + Ile-His-Pro-Phe-His + Asp-Arg-Val-Tyr

H2O + (des Asp)Angiotensin I <-> L-Leucine + Ile-His-Pro-Phe-His + Arg-Val-Tyr

H2O + 2ABz-Arg-Pro-Gly-Lys-Ser-Pro-Npa-Arg <-> L-Lysine + Ser-Pro-Npa-Arg + 2ABz-Arg-Pro-Gly

H2O + 2ABz-Arg-Pro-Gly-Leu-Ser-Pro-Npa-Arg <-> L-Leucine + Ser-Pro-Npa-Arg + 2ABz-Arg-Pro-Gly

H2O + Angiotensin II <-> Asp-Arg-Val-Tyr + Ile-His-Pro-Phe

H2O + Angiotensin III <-> Arg-Val-Tyr + Ile-His-Pro-Phe

H2O + Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg <-> Ser-Pro-Phe-Arg + Arg-Pro-Pro-Gly-Phe

H2O + Ac-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg <-> Ser-Pro-Phe-Arg + Ac-Arg-Pro-Pro-Gly-Phe

H2O + Arg-Pro-Gly-Phe-Ser-Pro-Phe-Arg <-> Ser-Pro-Phe-Arg + Arg-Pro-Gly-Phe

H2O + Arg-Pro-Pro-Gly-Clp-Ser-Pro-Clp-Arg <-> Ser-Pro-Clp-Arg + Arg-Pro-Pro-Gly-Clp

H2O + Arg-Pro-Hyp-Gly-Phe-Ser-Pro-Phe-Arg <-> Ser-Pro-Phe-Arg + Arg-Pro-Hyp-Gly-Phe

H2O + Arg-Pro-Pro-Gly-Phe-Thr-Pro-Phe-Arg <-> Arg-Pro-Pro-Gly-Phe + Thr-Pro-Phe-Arg

H2O + DArg-Arg-Pro-Hyp-Gly-Thi-Ser-DPhe-Thi-Arg <-> Ser-DPhe-Thi-Arg + DArg-Arg-Pro-Hyp-Gly-Thi

H2O + Arg-Pro-Pro-Gly-Phe-Ser-Pro-DPhe-Arg <-> Arg-Pro-Pro-Gly-Phe-Ser-Pro-DPhe-Arg

H2O + Arg-Pro-Pro-Gly-Npa-Ser-Pro-Phe-Arg <-> Ser-Pro-Phe-Arg + Arg-Pro-Pro-Gly-Npa

H2O + Arg-Pro-Pro-Gly-Npa-Ala-Pro-Phe-Arg <-> Arg-Pro-Pro-Gly-Npa + Ala-Pro-Phe-Arg

H2O + Arg-Pro-Pro-Gly-Npa-Arg-Pro-Phe-Arg <-> Arg-Pro-Pro-Gly-Npa + Arg-Pro-Phe-Arg

H2O + Arg-Pro-Pro-Gly-Npa-Phe-Pro-Phe-Arg <-> Arg-Pro-Pro-Gly-Npa + Phe-Pro-Phe-Arg

H2O + Arg-Pro-Pro-Gly-Npa-Lys-Pro-Phe-Arg <-> Arg-Pro-Pro-Gly-Npa + Lys-Pro-Phe-Arg

H2O + 2ABz-Arg-Pro-Gly-Phe-Ser-Pro-Npa-Arg <-> Ser-Pro-Npa-Arg + 2ABz-Arg-Pro-Gly-Phe

H2O + 2ABz-Arg-Pro-Ile-Phe-Ser-Pro-Npa-Arg <-> Ser-Pro-Npa-Arg + 2ABz-Arg-Pro-Ile-Phe

H2O + 2ABz-Arg-Hyp-Gly-Phe-Ser-Pro-Npa-Arg <-> Ser-Pro-Npa-Arg + 2ABz-Arg-Hyp-Gly-Phe

H2O + 2ABz-Arg-Gly-Pro-Phe-Ser-Pro-Npa-Arg <-> Ser-Pro-Npa-Arg + 2ABz-Arg-Gly-Pro-Phe

H2O + 2ABz-Arg-Pro-Gly-Ala-Ser-Pro-Npa-Arg <-> Ser-Pro-Npa-Arg + 2ABz-Arg-Pro-Gly-Ala

H2O + 2ABz-Arg-Pro-Gly-Glu-Ser-Pro-Npa-Arg <-> Ser-Pro-Npa-Arg + 2ABz-Arg-Pro-Gly-Glu

H2O + Azocasein <-> 2 Peptide

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 3.4.24.18

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