Enzyme Details

EC Classification

3.4.21.5

Enzyme name
(recommended)

thrombin

Alternative names

fibrinogenase
thrombase
thrombofort
topical
thrombin-C
tropostasin
activated blood-coagulation factor II
blood-coagulation factor IIa
factor IIa
E thrombin
beta-thrombin
gamma-thrombin

Classification

Hydrolases

Acting on peptide bonds (peptide hydrolases)

Serine endopeptidases

Catalyses reactions

H2O + Fibrinogen <-> Fibrin + Fibrinopeptide B

H2O + Fibrinogen <-> Fibrin + Fibrinopeptide A

H2O + Coagulation Factor XIII <-> Peptide + Coagulation Factor XIIIa

H2O + H-D-Ile-Pro-Arg-p-nitroanilide <-> 4-Nitroaniline + H-D-Ile-Pro-Arg

H2O + t-Butyloxycarbonyl-Val-Pro-Arg-7-Amino-4-methylcoumarin <-> t-Butyloxycarbonyl-Val-Pro-Arg + 7-Amino-4-methylcoumarin

H2O + p-Tosyl-L-arginine methyl ester <-> Methanol + p-Tosyl-L-arginine

H2O + N-Benzoyl-L-arginine-4-nitroanilide <-> 4-Nitroaniline + N-Benzoyl-L-arginine

H2O + Sar-Pro-Arg p-nitroanilide dihydrochloride <-> 4-Nitroaniline + Sar-Pro-Arg

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 3.4.21.5