Enzyme Details

 EC Classification 3.4.17.23
 Enzyme name
(recommended)		 angiotensin-converting enzyme 2
 Alternative names ACE-2
ACE2
hACE2
angiotensin converting enzyme 2
angiotensin converting enzyme-2
Tmem27
 Classification
Hydrolases
Acting on peptide bonds (peptide hydrolases)
Metallocarboxypeptidases
 Catalyses reactions
H2O + Angiotensin II <-> L-Phenylalanine + Angiotensin-(1-7)
H2O + (7-Methoxycoumarin-4-yl)acetyl-Ala-Pro-Lys-(2,4-dinitrophenyl) <-> N6-(2,4-Dinitrophenyl)-L-Lys + (7-Methoxycoumarin-4-yl)acetyl-Ala-Pro
H2O + Angiotensin I <-> L-Leucine + Angiotensin-(1-9)
H2O + Apelin-13 <-> L-Phenylalanine + Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro
H2O + des-Arg9-bradykinin <-> L-Phenylalanine + Arg-Pro-Pro-Gly-Phe-Ser-Pro
H2O + Lys-des-Arg9-bradykinin <-> L-Phenylalanine + Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro
H2O + beta-Casomorphin <-> L-Isoleucine + Tyr-Pro-Phe-Val-Glu-Pro
H2O + Dynorphin A (1-13) <-> L-Lysine + Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu
H2O + Neurotensin (1-8) <-> L-Arginine + pyroGlu-Leu-Tyr-Glu-Asn-Lys-Pro
ACE2 + Spike glycoprotein <-> Spike glycoprotein-ACE2 complex
ACE2 + Spike glycoprotein RBD-SD1 <-> Spike glycoprotein RBD-SD1-ACE2 complex
hACE2 + SARS-CoV-2 pseudovirus <-> hACE2 + SARS-CoV-2 pseudovirus
hACE2 + SARS-CoV pseudovirus <-> hACE2 + SARS-CoV pseudovirus
hDPP4 + MERS-CoV pseudovirus <-> hDPP4 + MERS-CoV pseudovirus
 External links Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop


View all entries for EC Class: 3.4.17.23



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