Enzyme Details

EC Classification

2.7.1.1

Enzyme name
(recommended)

hexokinase

Alternative names

ATP:D-hexose 6-phosphotransferase
hexokinase type IV glucokinase
hexokinase D
hexokinase type IV
hexokinase (phosphorylating)
ATP-dependent hexokinase
glucose ATP phosphotransferase

Classification

Transferases

Transferring phosphorous-containing groups

Phosphotransferases with an alcohol group as acceptor

Catalyses reactions

ATP + alpha-D-Glucose <-> alpha-D-Glucose 6-phosphate + ADP

ITP + D-Glucose <-> IDP + D-Glucose 6-phosphate

dATP + D-Glucose <-> dADP + D-Glucose 6-phosphate

ATP + D-Fructose <-> beta-D-Fructose 6-phosphate + ADP

ATP + H2O <-> ADP + Phosphate

ATP + D-Mannose <-> ADP + D-Mannose 6-phosphate

ATP + D-Glucose <-> ADP + D-Glucose 6-phosphate

ATP + D-Fructose <-> ADP + D-Fructose 6-phosphate

ATP + N-Acetyl-D-glucosamine <-> ADP + N-Acetyl-D-glucosamine 6-phosphate

ITP + D-Mannose <-> IDP + D-Mannose 6-phosphate

dATP + D-Mannose <-> dADP + D-Mannose 6-phosphate

ATP + D-Arabinose <-> ADP + D-Arabinose 5-phosphate

ATP + beta-D-Glucose <-> ADP + beta-D-Glucose 6-phosphate

ATP + D-Glucosamine <-> ADP + D-Glucosamine 6-phosphate

ITP + D-Glucosamine <-> IDP + D-Glucosamine 6-phosphate

dATP + D-Glucosamine <-> dADP + D-Glucosamine 6-phosphate

ATP + D-Hexose <-> ADP + D-Hexose 6-phosphate

ITP + D-Hexose <-> IDP + D-Hexose 6-phosphate

dATP + D-Hexose <-> dADP + D-Hexose 6-phosphate

ATP + Sorbitol <-> ADP + Sorbitol 6-phosphate

ITP + Sorbitol <-> IDP + Sorbitol 6-phosphate

dATP + Sorbitol <-> dADP + Sorbitol 6-phosphate

ATP + D-Allose <-> ADP + D-Allose 6-phosphate

ATP + beta-D-Fructose <-> beta-D-Fructose 6-phosphate + ADP

ATP + 2-Deoxy-D-glucose <-> ADP + 2-Deoxy-D-glucose 6-phosphate

ATP + 2-Deoxyglucose <-> ADP + 2-Deoxyglucose 6-phosphate

ATP + Glucose <-> ADP + Glucose 6-phosphate

ATP + 6-Aminoglucono-1,5-lactone <-> ADP + 6-Aminoglucose 1-phosphate

ATP + Fructose <-> ADP + Fructose 6-phosphate

ATP + 6-Aminoglucose <-> ADP + 6-Aminoglucose 6-phosphate

GTP + D-Glucose <-> GDP + D-Glucose 6-phosphate

ITP + D-Glucose <-> IDP + Glucose 6-phosphate

ATP + D-Glucose <-> ADP + Glucose 6-phosphate

ATP + 1-Deoxy-D-fructose <-> ADP + 1-Deoxy-D-fructose 6-phosphate

ATP + D-Talose <-> ADP + D-Talose 6-phosphate

ATP + 1,5-Anhydro-D-glucitol <-> ADP + 1,5-Anhydro-D-glucitol 6-phosphate

ATP + D-Gulose <-> ADP + D-Gulose 6-phosphate

ATP + beta-D-Arabinofuranose <-> ADP + D-Arabinose 5-phosphate

ATP + 1,5-Anhydro-D-mannitol <-> ADP + 1,5-Anhydro-D-mannitol 6-phosphate

ATP + 2,5-Anhydro-D-mannitol <-> ADP + 2,5-Anhydro-D-mannitol 6-phosphate

ATP + 2,5-Anhydro-D-glucitol <-> ADP + 2,5-Anhydro-D-glucitol 6-phosphate

ATP + 2,5-Anhydro-D-mannose <-> ADP + 2,5-Anhydro-D-mannose 6-phosphate

ATP + D-Galactose <-> ADP + D-Galactose 6-phosphate

UTP + D-Glucose <-> UDP + Glucose 6-phosphate

CTP + D-Glucose <-> CDP + Glucose 6-phosphate

CTP + D-Glucose <-> CDP + D-Glucose 6-phosphate

UTP + D-Glucose <-> UDP + D-Glucose 6-phosphate

ATP + D-Mannosamine <-> ADP + D-Mannosamine 6-phosphate

D-Glucose + dTTP <-> D-Glucose 6-phosphate + TDP

ATP + 2-Deoxy-2-fluoro-D-glucose <-> ADP + 2-Deoxy-2-fluoro-D-glucose 6-phosphate

H2O + 2-Deoxy-D-glucose 6-phosphate <-> Phosphate + 2-Deoxy-D-glucose

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 2.7.1.1

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