Enzyme Details

EC Classification

2.4.1.212

Enzyme name
(recommended)

hyaluronan synthase

Alternative names

Alternating UDP-alpha-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1->3)-[nascent hyaluronan] 4-N-acetyl-beta-D-glucosaminyltransferase and UDP-alpha-D-glucuronate:N-acetyl-beta-D-glucosaminyl-(1->4)-[nascent hyaluronan] 3-beta-D-glucuronosyltransferase
spHAS
seHAS

Classification

Transferases

Glycosyltransferases

Hexosyltransferases

Catalyses reactions

n UDP-N-acetyl-D-glucosamine + n UDPglucuronate <-> 2n UDP + Hyaluronate

UDP-N-acetyl-D-glucosamine + beta-D-Glucuronosyl-(1-3)-N-acetyl-beta-D-glucosaminyl-(1-4)-(nascent hyaluronan) <-> UDP + N-Acetyl-beta-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-N-acetyl-beta-D-glucosaminyl-(1-4)-(nascent hyaluronan)

UDP-D-glucuronate + N-Acetyl-beta-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-(nascent hyaluronan) <-> UDP + beta-D-Glucuronosyl-(1-3)-N-acetyl-beta-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-(nascent hyaluronan)

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 2.4.1.212