Enzyme Details

EC Classification

2.1.1.6

Enzyme name
(recommended)

catechol O-methyltransferase

Alternative names

S-adenosyl-L-methionine:catechol O-methyltransferase
COMT I
COMT II
S-COMT (soluble form of catechol-O-methyltransferase)
MB-COMT (membrane-bound form of catechol-O-methyltransferase)
catechol methyltransferase
catecholamine O-methyltransferase

Classification

Transferases

Transferring one-carbon groups

Methyltransferases

Catalyses reactions

S-Adenosyl-L-methionine + Catechol <-> S-Adenosyl-L-homocysteine + Guaiacol

S-Adenosyl-L-methionine + L-Noradrenaline <-> S-Adenosyl-L-homocysteine + L-Normetanephrine

S-Adenosyl-L-methionine + L-Adrenaline <-> S-Adenosyl-L-homocysteine + L-Metanephrine

S-Adenosyl-L-methionine + 3,4-Dihydroxyphenylacetate <-> S-Adenosyl-L-homocysteine + Homovanillate

S-Adenosyl-L-methionine + Dopamine <-> S-Adenosyl-L-homocysteine + 3-Methoxytyramine

S-Adenosyl-L-methionine + 3,4-Dihydroxyphenylethyleneglycol <-> S-Adenosyl-L-homocysteine + 3-Methoxy-4-hydroxyphenylethyleneglycol

S-Adenosyl-L-methionine + 3,4-Dihydroxymandelate <-> S-Adenosyl-L-homocysteine + 3-Methoxy-4-hydroxymandelate

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 2.1.1.6