Enzyme Details

EC Classification

2.1.1.43

Enzyme name
(recommended)

histone-lysine N-methyltransferase

Alternative names

S-adenosyl-L-methionine:histone-L-lysine N6-methyltransferase
protein methylase III
protein methylase 3
protein (lysine) methyltransferase
protein methyltransferase II
protein-lysine N-methyltransferase
histone H1-specific S-adenosylmethionine:protein-lysine N-methyltransferase
S-adenosyl-L-methionine:histone-L-lysine 6-N-methyltransferase

Classification

Transferases

Transferring one-carbon groups

Methyltransferases

Catalyses reactions

S-Adenosyl-L-methionine + Protein lysine <-> S-Adenosyl-L-homocysteine + Protein N6-methyl-L-lysine

S-Adenosyl-L-methionine + Histone-L-lysine <-> S-Adenosyl-L-homocysteine + Histone N6-methyl-L-lysine

S-Adenosyl-L-methionine + Protein N6-methyl-L-lysine <-> S-Adenosyl-L-homocysteine + Protein N6,N6-dimethyl-L-lysine

S-Adenosyl-L-methionine + Protein N6,N6-dimethyl-L-lysine <-> S-Adenosyl-L-homocysteine + Protein N6,N6,N6-trimethyl-L-lysine

S-Adenosyl-L-methionine + Histone H3-K4 <-> S-Adenosyl-L-homocysteine + Histone H3-[monomethyl]K4

S-Adenosyl-L-methionine + TAF10-K189 <-> S-Adenosyl-L-homocysteine + TAF10-[monomethyl]K189

S-Adenosyl-L-methionine + p53-K372 <-> S-Adenosyl-L-homocysteine + p53-[monomethyl]K372

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 2.1.1.43