Enzyme Details

EC Classification

2.1.1.100

Enzyme name
(recommended)

protein-S-isoprenylcysteine O-methyltransferase

Alternative names

S-adenosyl-L-methionine:protein-C-terminal-S-farnesyl-L-cysteine O-methyltransferase
farnesyl cysteine C-terminal methyltransferase
farnesyl-protein carboxymethyltransferase
protein C-terminal farnesylcysteine O-methyltransferase
farnesylated protein C-terminal O-methyltransferase
isoprenylated protein methyltransferase
prenylated protein methyltransferase
protein S-farnesylcysteine C-terminal methyltransferase
S-farnesylcysteine methyltransferase
prenylcysteine carboxylmethyltransferase [misleading]
prenylcysteine carboxymethyltransferase [misleading]
prenylcysteine methyltransferase

Classification

Transferases

Transferring one-carbon groups

Methyltransferases

Catalyses reactions

S-Adenosyl-L-methionine + Protein C-terminal S-farnesyl-L-cysteine <-> S-Adenosyl-L-homocysteine + Protein C-terminal S-farnesyl-L-cysteine methyl ester

S-Adenosyl-L-methionine + S-trans-Geranyl-Leu-Ala-Arg-Tyr-Lys-Cys <-> S-Adenosyl-L-homocysteine + S-trans-Geranyl-Leu-Ala-Arg-Tyr-Lys-Cys methyl ester

S-Adenosyl-L-methionine + S-trans,trans-Farnesyl-Leu-Ala-Arg-Tyr-Lys-Cys <-> S-Adenosyl-L-homocysteine + S-trans,trans-Farnesyl-Leu-Ala-Arg-Tyr-Lys-Cys methyl ester

S-Adenosyl-L-methionine + S-all-trans-Geranylgeranyl-Leu-Ala-Arg-Tyr-Lys-Cys <-> S-Adenosyl-L-homocysteine + S-all-trans-Geranylgeranyl-Leu-Ala-Arg-Tyr-Lys-Cys methyl ester

S-Adenosyl-L-methionine + S-Octyl-Leu-Ala-Arg-Tyr-Lys-Cys <-> S-Adenosyl-L-homocysteine + S-Octyl-Leu-Ala-Arg-Tyr-Lys-Cys methyl ester

S-Adenosyl-L-methionine + S-Decyl-Leu-Ala-Arg-Tyr-Lys-Cys <-> S-Adenosyl-L-homocysteine + S-Decyl-Leu-Ala-Arg-Tyr-Lys-Cys methyl ester

S-Adenosyl-L-methionine + S-Tridecyl-Leu-Ala-Arg-Tyr-Lys-Cys <-> S-Adenosyl-L-homocysteine + S-Tridecyl-Leu-Ala-Arg-Tyr-Lys-Cys methyl ester