Enzyme Details

 EC Classification 1.6.5.2
 Enzyme name
(recommended)
NAD(P)H dehydrogenase (quinone)
 Alternative names NAD(P)H:quinone oxidoreductase
menadione reductase
phylloquinone reductase
quinone reductase
dehydrogenase, reduced nicotinamide adenine dinucleotide (phosphate, quinone)
DT-diaphorase
flavoprotein NAD(P)H-quinone reductase
menadione oxidoreductase
NAD(P)H dehydrogenase
NAD(P)H menadione reductase
NAD(P)H-quinone dehydrogenase
NAD(P)H-quinone oxidoreductase
NAD(P)H: (quinone-acceptor)oxidoreductase
NAD(P)H: menadione oxidoreductase
NADH-menadione reductase
naphthoquinone reductase
p-benzoquinone reductase
reduced NAD(P)H dehydrogenase
viologen accepting pyridine nucleotide oxidoreductase
vitamin K reductase
diaphorase
reduced nicotinamide-adenine dinucleotide (phosphate) dehydrogenase
vitamin-K reductase
NAD(P)H2 dehydrogenase (quinone)
NQO1
QR1
NAD(P)H:(quinone-acceptor) oxidoreductase
 Classification
Oxidoreductases
Acting on NADH or NADPH
With a quinone or similar compound as acceptor
 Catalyses reactions
H+ + NADPH + Acceptor <-> NADP+ + Reduced acceptor
NADH + H+ + Vitamin K <-> NAD+ + Reduced vitamin K
H+ + NADPH + Menadione <-> NADP+ + Menadiol
NADH + H+ + Menadione <-> NAD+ + Menadiol
NADH + H+ + 2,6-Dichloroindophenol <-> NAD+ + Reduced 2,6-dichlorophenolindophenol
NADH + Methyl red <-> NAD+ + Reduced methyl red
NADH + 5-(Aziridin-1-yl)-2,4-dinitrobenzamide <-> NAD+ + 5-(Aziridin-1-yl)-4-(hydroxyamino)-2-nitrobenzamide
NADH + H+ + 2,6-Dimethyl-1,4-benzoquinone <-> NAD+ + 2,6-Dimethylhydroquinone
H+ + NADPH + 2,6-Dimethyl-1,4-benzoquinone <-> NADP+ + 2,6-Dimethylhydroquinone
NADH + H+ + 5-Hydroxy-1,4-naphthoquinone <-> NAD+ + 1,4,5-Naphthalenetriol
H+ + NADPH + 5-Hydroxy-1,4-naphthoquinone <-> NADP+ + 1,4,5-Naphthalenetriol
NADH + thio-NAD+ <-> NAD+ + thio-NADH
NADPH + thio-NAD+ <-> NADP+ + thio-NADH
H+ + NADPH + 1,4-Benzoquinone <-> NADP+ + Hydroquinone
H+ + NADPH + 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone <-> NADP+ + 2,3-Dichloro-5,6-dicyanohydroquinone
H+ + NADPH + Phenyl-1,4-benzoquinone <-> NADP+ + Phenylhydroquinone
H+ + NADPH + O2 + Hydroquinone <-> H2O + NADP+ + Benzene-1,2,4-triol
NADH + 2 Hexacyanoferrate(III) <-> NAD+ + H+ + 2 Hexacyanoferrate(II)
NADPH + 2 Hexacyanoferrate(III) <-> H+ + NADP+ + 2 Hexacyanoferrate(II)
NADH + H+ + 1,4-Benzoquinone <-> NAD+ + Hydroquinone
NADPH + Methyl-1,4-benzoquinone <-> NADP+ + Methylhydroquinone
 External links Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop


View all entries for EC Class: 1.6.5.2



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