Enzyme Details

EC Classification

1.3.1.48

Enzyme name
(recommended)

15-oxoprostaglandin 13-oxidase

Alternative names

11alpha-hydroxy-9,15-dioxoprostanoate:NAD(P)+ Delta13-oxidoreductase
15-oxo-Delta13-prostaglandin reductase
Delta13-15-ketoprostaglandin reductase
15-ketoprostaglandin Delta13-reductase
prostaglandin Delta13-reductase
prostaglandin 13-reductase
15-ketoprostaglandin Delta13-reductase
(5Z)-(15S)-11alpha-hydroxy-9,15-dioxoprostanoate:NAD(P)+ Delta13-oxidoreductase
(5Z)-11alpha-hydroxy-9,15-dioxoprost-5-enoate:NAD(P)+ Delta13-oxidoreductase

Classification

Oxidoreductases

Acting on the CH-CH group of donors

With NAD(+) or NADP(+) as acceptor

Catalyses reactions

NAD+ + (5Z)-(15S)-11alpha-Hydroxy-9,15-dioxoprostanoate <-> NADH + H+ + (5Z,13E)-11alpha-Hydroxy-9,15-dioxoprost-13-enoate

H+ + NADPH + (5Z,13E)-11alpha-Hydroxy-9,15-dioxoprost-13-enoate <-> NADP+ + (5Z)-(15S)-11alpha-Hydroxy-9,15-dioxoprostanoate

H+ + NADPH + 15-Keto-prostaglandin F2alpha <-> NADP+ + 13,14-Dihydro-15-keto-prostaglandin F2alpha

H+ + NADPH + 15-Keto-prostaglandin E1 <-> NADP+ + 13,14-Dihydro-15-keto-prostaglandin E1

H+ + NADPH + 15-Keto-prostaglandin F1alpha <-> NADP+ + 13,14-Dihydro-15-keto-prostaglandin F1alpha

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 1.3.1.48