| EC Classification |
1.3.1.3
|
Enzyme name
(recommended) |
Delta4-3-oxosteroid 5beta-reductase |
| Alternative names |
5beta-cholestan-3-one:NADP+ 4,5-oxidoreductase
3-oxo-Delta4-steroid 5beta-reductase
5beta-reductase
androstenedione 5beta-reductase
cholestenone 5beta-reductase
cortisone 5beta-reductase
cortisone beta-reductase
cortisone Delta4-5beta-reductase
steroid 5beta-reductase
testosterone 5beta-reductase
Delta4-3-ketosteroid 5beta-reductase
Delta4-5beta-reductase
Delta4-hydrogenase
4,5beta-dihydrocortisone:NADP+ Delta4-oxidoreductase
3-oxo-5beta-steroid:NADP+ Delta4-oxidoreductase
|
| Classification |
| Oxidoreductases |
| Acting on the CH-CH group of donors |
| With NAD(+) or NADP(+) as acceptor |
|
| Catalyses reactions
|
| H+ + NADPH + Progesterone <-> NADP+ + 5beta-Pregnane-3,20-dione |
| NADP+ + 5beta-Cholestan-3-one <-> H+ + NADPH + Cholest-4-en-3-one |
| NADP+ + 11beta,17alpha,21-Trihydroxy-5beta-pregnane-3,20-dione <-> H+ + NADPH + Cortisol |
| Cortisol <-> 11beta,17alpha,21-Trihydroxy-5beta-pregnane-3,20-dione |
| NADP+ + 17alpha,21-Dihydroxy-5beta-pregnane-3,11,20-trione <-> H+ + NADPH + Cortisone |
| NADP+ + 11beta,21-Dihydroxy-3,20-oxo-5beta-pregnan-18-al <-> H+ + NADPH + Aldosterone |
| NADP+ + 7alpha-Hydroxy-5beta-cholestan-3-one <-> H+ + NADPH + 7alpha-Hydroxycholest-4-en-3-one |
| NADP+ + 7alpha,12alpha-Dihydroxy-5beta-cholestan-3-one <-> H+ + NADPH + 7alpha,12alpha-Dihydroxycholest-4-en-3-one |
| H+ + NADPH + Androst-4-ene-3,17-dione <-> NADP+ + 5beta-Androstane-3,17-dione |
| H+ + NADPH + Testosterone <-> NADP+ + 5beta-Androstane-17beta-ol-3-one |
| H+ + NADPH + Boldenone <-> NADP+ + 5beta-Androst-1-en-17beta-ol-3-one |
|
| External links
|
Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop
|
|
View all entries for EC Class:
1.3.1.3
|
