Enzyme Details

EC Classification

1.3.1.22

Enzyme name
(recommended)

cholestenone 5alpha-reductase

Alternative names

3-oxo-5alpha-steroid:NADP+ Delta4-oxidoreductase
testosterone Delta4-5alpha-reductase
steroid 5alpha-reductase
3-oxosteroid Delta4-dehydrogenase
5alpha-reductase
steroid 5alpha-hydrogenase
3-oxosteroid 5alpha-reductase
testosterone Delta4-hydrogenase
4-ene-3-oxosteroid 5alpha-reductase
reduced nicotinamide adenine dinucleotide phosphate:Delta4-3-ketosteroid 5alpha-oxidoreductase
4-ene-5alpha-reductase
Delta4-3-ketosteroid 5alpha-oxidoreductase
cholest-4-en-3-one 5alpha-reductase
testosterone 5alpha-reductase

Classification

Oxidoreductases

Acting on the CH-CH group of donors

With NAD(+) or NADP(+) as acceptor

Catalyses reactions

NADP+ + 5alpha-Pregnane-3,20-dione <-> H+ + NADPH + Progesterone

NADP+ + 5alpha-Cholestan-3-one <-> H+ + NADPH + Cholest-4-en-3-one

NADP+ + 5alpha-Androstane-17beta-ol-3-one <-> H+ + NADPH + Testosterone

H+ + NADPH + Corticosterone <-> NADP+ + 5alpha-Dihydrocorticosterone

H+ + NADPH + Cortisol <-> NADP+ + 11beta,17alpha,21-Trihydroxy-5alpha-pregnane-3,20-dione

H+ + NADPH + Androst-4-ene-3,17-dione <-> NADP+ + 5alpha-Androstane-3,17-dione

H+ + NADPH + Campest-4-en-3-one <-> NADP+ + 5alpha-Campestan-3-one

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 1.3.1.22