Enzyme Details

EC Classification

1.2.1.88

Enzyme name
(recommended)

L-glutamate gamma-semialdehyde dehydrogenase

Alternative names

Delta1-pyrroline-5-carboxylate dehydrogenase
1-pyrroline dehydrogenase
pyrroline-5-carboxylate dehydrogenase
pyrroline-5-carboxylic acid dehydrogenase
L-pyrroline-5-carboxylate-NAD+ oxidoreductase
1-pyrroline-5-carboxylate:NAD+ oxidoreductase
Delta1-pyrroline-5-carboxylic acid dehydrogenase
L-glutamate gamma-semialdehyde:NAD+ oxidoreductase

Classification

Oxidoreductases

Acting on the aldehyde or oxo group of donors

With NAD(+) or NADP(+) as acceptor

Catalyses reactions

H2O + NADP+ + Acetaldehyde <-> H+ + NADPH + Acetate

NAD+ + H2O + L-Glutamate 5-semialdehyde <-> NADH + H+ + L-Glutamate

NAD+ + 2 H2O + (S)-1-Pyrroline-5-carboxylate <-> NADH + H+ + L-Glutamate

NAD+ + 2 H2O + L-1-Pyrroline-3-hydroxy-5-carboxylate <-> NADH + H+ + L-erythro-4-Hydroxyglutamate

NAD+ + H2O + Acetaldehyde <-> NADH + H+ + Acetate

2 H2O + NADP+ + (S)-1-Pyrroline-5-carboxylate <-> H+ + L-Glutamate + NADPH

NAD+ + H2O + Succinate semialdehyde <-> NADH + H+ + Succinate