Enzyme Details

EC Classification

1.2.1.49

Enzyme name
(recommended)

2-oxoaldehyde dehydrogenase (NADP+)

Alternative names

2-oxoaldehyde:NADP+ 2-oxidoreductase
alpha-ketoaldehyde dehydrogenase
methylglyoxal dehydrogenase
NADP+-linked alpha-ketoaldehyde dehydrogenase
2-ketoaldehyde dehydrogenase
NADP+-dependent alpha-ketoaldehyde dehydrogenase
2-oxoaldehyde dehydrogenase (NADP+)

Classification

Oxidoreductases

Acting on the aldehyde or oxo group of donors

With NAD(+) or NADP(+) as acceptor

Catalyses reactions

H2O + NADP+ + 2-Oxoaldehyde <-> H+ + NADPH + 2-Oxo acid

H2O + NADP+ + Methylglyoxal <-> Pyruvate + H+ + NADPH

NADP+ + L-Lactaldehyde <-> H+ + NADPH + Methylglyoxal

H2O + NADP+ + Glyoxal <-> H+ + NADPH + Glyoxylate

H2O + NADP+ + Hydroxypyruvaldehyde <-> H+ + NADPH + 3-Hydroxypyruvate

H2O + NADP+ + Phenylglyoxal <-> H+ + NADPH + alpha-Oxo-benzeneacetic acid

H2O + NADP+ + 2-Keto-3-deoxy-D-glucose <-> H+ + NADPH + 2-Keto-3-deoxy-D-gluconate

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 1.2.1.49