Enzyme Details

EC Classification

1.2.1.3

Enzyme name
(recommended)

aldehyde dehydrogenase (NAD+)

Alternative names

aldehyde:NAD+ oxidoreductase
CoA-independent aldehyde dehydrogenase
m-methylbenzaldehyde dehydrogenase
NAD-aldehyde dehydrogenase
NAD-dependent 4-hydroxynonenal dehydrogenase
NAD-dependent aldehyde dehydrogenase
NAD-linked aldehyde dehydrogenase
propionaldehyde dehydrogenase
aldehyde dehydrogenase (NAD)

Classification

Oxidoreductases

Acting on the aldehyde or oxo group of donors

With NAD(+) or NADP(+) as acceptor

Catalyses reactions

NAD+ + H2O + Aldehyde <-> NADH + H+ + Acid

NAD+ + H2O + Glycolaldehyde <-> NADH + H+ + Glycolate

H2O + NADP+ + Acetaldehyde <-> H+ + NADPH + Acetate

NAD+ + H2O + Acetaldehyde <-> NADH + H+ + Acetate

NAD+ + H2O + Aldehyde <-> NADH + H+ + Carboxylate

NAD+ + H2O + Formaldehyde <-> NADH + H+ + Formate

NAD+ + H2O + Aldehyde <-> NADH + H+ + Fatty acid

NAD+ + 2 H2O + (S)-1-Pyrroline-5-carboxylate <-> NADH + H+ + L-Glutamate

NAD+ + H2O + Succinate semialdehyde <-> NADH + H+ + Succinate

NAD+ + H2O + 3-Aminopropanal <-> NADH + H+ + beta-Alanine

NAD+ + H2O + Benzaldehyde <-> NADH + H+ + Benzoate

H2O + NADP+ + Benzaldehyde <-> H+ + NADPH + Benzoate

NAD+ + H2O + 16-Hexadecanal <-> NADH + H+ + Palmitate

NAD+ + H2O + D-Glyceraldehyde <-> NADH + H+ + D-Glycerate

H2O + NADP+ + 4-Aminobutanal <-> H+ + NADPH + 4-Aminobutanoate

NAD+ + H2O + Phenylacetaldehyde <-> NADH + H+ + Phenylacetic acid

NAD+ + H2O + 4-Aminobutanal <-> NADH + H+ + 4-Aminobutanoate

NAD+ + H2O + Betaine aldehyde <-> NADH + H+ + Betaine

NAD+ + H2O + Indole-3-acetaldehyde <-> NADH + H+ + Indole-3-acetate

NAD+ + H2O + 2-Propyn-1-al <-> NADH + H+ + Propynoate

NAD+ + 2 H2O + D-Glucurono-3,6-lactone <-> NADH + H+ + D-Glucarate

NAD+ + H2O + 4-Trimethylammoniobutanal <-> NADH + H+ + 4-Trimethylammoniobutanoate

NAD+ + H2O + 3,4-Dihydroxyphenylacetaldehyde <-> NADH + H+ + 3,4-Dihydroxyphenylacetate

NAD+ + H2O + (S)-Methylmalonate semialdehyde <-> NADH + H+ + Methylmalonate

NAD+ + H2O + Imidazole-4-acetaldehyde <-> NADH + H+ + Imidazole-4-acetate

NAD+ + H2O + 3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al <-> NADH + H+ + 3alpha,7alpha-Dihydroxy-5beta-cholestanate

NAD+ + H2O + 5-Hydroxyindoleacetaldehyde <-> NADH + H+ + 5-Hydroxyindoleacetate

NAD+ + H2O + N4-Acetylaminobutanal <-> NADH + H+ + 4-Acetamidobutanoate

NAD+ + H2O + 3-Butyn-1-al <-> NADH + H+ + 3-Butynoate

NAD+ + H2O + Chloroacetaldehyde <-> NADH + H+ + Chloroacetic acid

NAD+ + H2O + Perillyl aldehyde <-> NADH + H+ + Perillic acid

NAD+ + H2O + Butanal <-> NADH + H+ + Butanoate

NAD+ + H2O + 1-Octanal <-> NADH + H+ + Octanoate

NAD+ + H2O + Decanal <-> NADH + H+ + Decanoate

NAD+ + H2O + Hexanal <-> NADH + H+ + Hexanoate

NAD+ + H2O + Glutaral <-> NADH + H+ + 5-Oxopentanoate

NAD+ + H2O + Dodecanal <-> NADH + H+ + Dodecanoate

NAD+ + H2O + 2,4-Dinitrobenzaldehyde <-> NADH + H+ + 2,4-Dinitrobenzoate

NAD+ + H2O + 2-Naphthaldehyde <-> NADH + H+ + 2-Naphthoic acid

NAD+ + H2O + 2-quinolinone-4-carboxaldehyde <-> NADH + H+ + 2-quinolinone-4-carboxylate

NAD+ + H2O + Veratraldehyde <-> NADH + H+ + 3,4-Dimethoxybenzoate

NAD+ + H2O + 3-Pyridinecarboxaldehyde <-> NADH + H+ + Nicotinate

NAD+ + H2O + 4-Methoxy-1-naphthaldehyde <-> NADH + H+ + 4-Methoxy-1-naphtacetate

NAD+ + H2O + 5-Bromo-1-naphthaldehyde <-> NADH + H+ + 5-Bromo-1-naphthoate

NAD+ + H2O + 5-Methoxyindole-3-carboxaldehyde <-> NADH + H+ + 5-Methoxyindolecarboxylate

NAD+ + H2O + 5-Nitro-1-naphthaldehyde <-> NADH + H+ + 5-Nitro-1-naphthoate

NAD+ + H2O + 6,7-Dimethoxycoumarin-4-carboxaldehyde <-> NADH + H+ + 6,7-Dimethoxycoumarin-4-carboxylate

NAD+ + H2O + 6-(dimethylamino)-2-naphthaldehyde <-> NADH + H+ + 6-(dimethylamino)-2-naphthoate

NAD+ + H2O + 6-Methoxy-2-quinolinone-4-carboxaldehyde <-> NADH + H+ + 6-Methoxy-2-quinolinone-4-carboxylate

NAD+ + H2O + 7-(dimethylamino)coumarin-4-carboxaldehyde <-> NADH + H+ + 7-(dimethylamino)coumarin-4-carboxylate

NAD+ + H2O + 7-Acetoxycoumarin-4-carboxaldehyde <-> NADH + H+ + 7-Acetoxycoumarin-4-carboxylate

NAD+ + H2O + 7-Hydroxycoumarin-4-carboxaldehyde <-> NADH + H+ + 7-Hydroxycoumarin-4-carboxylate

NAD+ + H2O + 7-Methoxy-2-quinolinone-4-carboxaldehyde <-> NADH + H+ + 7-Methoxy-2-quinolinone-4-carboxylate

NAD+ + H2O + 7-Methoxycoumarin-4-carboxaldehyde <-> NADH + H+ + 7-Methoxycoumarin-4-carboxylate

NAD+ + H2O + Fluorene-2-carboxaldehyde <-> NADH + H+ + Fluorene-2-carboxylate

NAD+ + H2O + Cinnamaldehyde <-> NADH + H+ + Cinnamic acid

NAD+ + H2O + Heptanal <-> NADH + H+ + Heptanoate

NAD+ + H2O + Hydrocinnamaldehyde <-> NADH + H+ + Phenylpropanoate

NAD+ + H2O + Glyceraldehyde <-> NADH + H+ + Glycerate

NAD+ + H2O + Pentanal <-> NADH + H+ + Pentanoate

NAD+ + H2O + Phenanthrene-9-carboxaldehyde <-> NADH + H+ + Phenanthrene-9-carboxylate

H2O + NADP+ + Propanal <-> H+ + NADPH + Propanoate

NAD+ + H2O + Quinoline-3-carboxaldehyde <-> NADH + H+ + Quinoline-3-carboxylate

NAD+ + H2O + Quinoline-4-carboxaldehyde <-> NADH + H+ + 4-Quinolinecarboxylic acid

NAD+ + H2O + alpha-Phenylpropionaldehyde <-> NADH + H+ + alpha-Phenylpropionate

NAD+ + H2O + 3-Hydroxybenzaldehyde <-> NADH + H+ + 3-Hydroxybenzoate

NAD+ + H2O + 3-Methoxybenzaldehyde <-> NADH + H+ + m-Methoxybenzoate

NAD+ + H2O + m-Methylbenzaldehyde <-> NADH + H+ + m-Methylbenzoate

NAD+ + H2O + Salicylaldehyde <-> NADH + H+ + Salicylate

NAD+ + H2O + 2-Methoxybenzaldehyde <-> NADH + H+ + o-Methoxybenzoate

NAD+ + H2O + o-Methylbenzaldehyde <-> NADH + H+ + o-Toluate

NAD+ + H2O + o-Nitrobenzaldehyde <-> NADH + H+ + o-Nitrobenzoate

NAD+ + H2O + p-(dimethylamino)benzaldehyde <-> NADH + H+ + p-(dimethylamino)benzoate

NAD+ + H2O + p-(dimethylamino)cinnamaldehyde <-> NADH + H+ + p-(dimethylamino)cinnamate

NAD+ + H2O + 4-Methoxybenzaldehyde <-> NADH + H+ + 4-Methoxybenzoate

NAD+ + H2O + p-Tolualdehyde <-> NADH + H+ + Toluate

NAD+ + H2O + p-Nitrobenzaldehyde <-> NADH + H+ + p-Nitrobenzoate

NAD+ + H2O + p-Nitrocinnamaldehyde <-> NADH + H+ + p-Nitrocinnamate

NAD+ + H2O + trans-Cinnamaldehyde <-> NADH + H+ + trans-Cinnamate

2 NAD+ + 2 H2O + Malondialdehyde <-> 2 NADH + H+ + Malonate

NAD+ + H2O + 4-Hydroxy-2-nonenal <-> NADH + H+ + 4-Hydroxy-2-nonenoic acid

H2O + p-Nitrophenyl acetate <-> Acetate + p-Nitrophenol

H2O + p-Nitrophenyl propionate <-> Propanoate + p-Nitrophenol

NAD+ + H2O + Propanal <-> NADH + H+ + Propanoate

H2O + NADP+ + 20-CHO-Leukotriene B4 <-> H+ + NADPH + 20-COOH-Leukotriene B4

NAD+ + H2O + 20-CHO-6-trans-12-epi-Leukotriene B4 <-> NADH + H+ + 20-COOH-6-trans-12-epi-Leukotriene B4

NAD+ + H2O + Citral <-> NADH + H+ + 3,7-Dimethylocta-2,6-dienoic acid

NAD+ + H2O + Geranial <-> NADH + H+ + (2E)-3,7-Dimethylocta-2,6-dienoic acid

NAD+ + H2O + 20-CHO-Leukotriene B4 <-> NADH + H+ + 20-COOH-Leukotriene B4

NAD+ + H2O + cis-Citral <-> NADH + H+ + (2Z)-3,7-Dimethylocta-2,6-dienoic acid

H2O + Propanal + 3-Acetylpyridine-adenine dinucleotide <-> H+ + Propanoate + Reduced 3-acetylpyridine-adenine dinucleotide

NAD+ + H2O + 4-Carboxybenzaldehyde <-> NADH + H+ + Terephthalate

H2O + Deamino-NAD+ + Propanal <-> H+ + Propanoate + Deamino-NADH

NAD+ + H2O + 3-Methylbutanal <-> NADH + H+ + Isovaleric acid

NAD+ + H2O + L-Glyceraldehyde <-> NADH + H+ + L-Glycerate

NAD+ + H2O + 3,4-Dihydroxyphenylglycolaldehyde <-> NADH + H+ + 3,4-Dihydroxyphenylglycolate

H2O + p-(dimethylamino)cinnamoylimidazole <-> Imidazole + p-(dimethylamino)cinnamate

NAD+ + H2O + Glyceraldehyde 3-phosphate <-> Glycerate 3-phosphate + NADH + H+

NAD+ + H2O + Glutathione-4-oxonon-2-enal <-> NADH + H+ + Glutathione-4-oxonon-2-enoic acid

NAD+ + H2O + 4-Guanidinobutanal <-> NADH + H+ + 4-Guanidinobutanoate

NAD+ + H2O + 5-Aminopentanal <-> NADH + H+ + 5-Aminopentanoate

NAD+ + H2O + N-(3-Propanal)-1,4-diaminobutane <-> NADH + H+ + Carboxyethyl putrescine

NAD+ + H2O + N-(3-Aminopropyl)-N'-(3-propanal)-1,4-diaminobutane <-> NADH + H+ + Carboxyethyl spermidine

NAD+ + H2O + N,N'-Bis(3-propanal)-1,4-diaminobutane <-> NADH + H+ + N-(3-Propanal)-N'-(3-propanoyl)-1,4-diaminobutane

NAD+ + H2O + 5-Imidazoleacetaldehyde <-> NADH + H+ + 5-Imidazoleacetate

NAD+ + H2O + Acrolein <-> NADH + H+ + Acrylate

NAD+ + H2O + all-trans-Retinal <-> NADH + H+ + Retinoate

NAD+ + H2O + D-Lactaldehyde <-> NADH + H+ + D-Lactate

NAD+ + H2O + L-Lactaldehyde <-> NADH + H+ + L-Lactate

NAD+ + H2O + 2,5-Dioxopentanoate <-> NADH + H+ + 2-Oxoglutarate

H2O + NADP+ + 2,5-Dioxopentanoate <-> H+ + NADPH + 2-Oxoglutarate

H2O + NADP+ + Butanal <-> H+ + NADPH + Butanoate

H2O + NADP+ + Pentanal <-> H+ + NADPH + Pentanoate

H2O + NADP+ + Hexanal <-> H+ + NADPH + Hexanoate

H2O + NADP+ + Heptanal <-> H+ + NADPH + Heptanoate

H2O + NADP+ + 1-Octanal <-> H+ + NADPH + Octanoate

NAD+ + H2O + 9-cis-Retinal <-> NADH + H+ + Retinoate

NAD+ + H2O + Nonanal <-> NADH + H+ + Nonanoate

NAD+ + H2O + trans-2-Nonenal <-> NADH + H+ + trans-2-Nonenoic acid

2 NAD+ + 4 ALDH <-> Enzyme-ligand complex

2 NAD+ + 2 ALDH <-> Enzyme-ligand complex

2 NADH + 4 ALDH <-> Enzyme-ligand complex

4 NADH + 4 ALDH <-> Enzyme-ligand complex

2 1,N6-etheno-NAD+ + 4 ALDH <-> Enzyme-ligand complex

4 1,N6-etheno-NAD+ + 4 ALDH <-> Enzyme-ligand complex

NAD+ + 1-Propanol <-> NADH + H+ + Propanal

NAD+ + Acetoin <-> NADH + H+ + Dimethylglyoxal

H+ + NADPH + Dimethylglyoxal <-> NADP+ + Acetoin

NAD+ + H2O + 4-(Dimethylamino)butanal <-> NADH + 4-(Dimethylamino)butyrate

NAD+ + H2O + trans-2-Hexenal <-> NADH + H+ + trans-2-Hexenoic acid

NAD+ + H2O + N,N,N-Trimethyl-3-aminopropionaldehyde <-> NADH + Beta-alanine betaine

NAD+ + ALDH9A1 <-> Enzyme-ligand complex

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
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