Enzyme Details

EC Classification

1.2.1.23

Enzyme name
(recommended)

2-oxoaldehyde dehydrogenase (NAD+)

Alternative names

2-oxoaldehyde:NAD+ 2-oxidoreductase
alpha-ketoaldehyde dehydrogenase
methylglyoxal dehydrogenase
NAD+-linked alpha-ketoaldehyde dehydrogenase
2-ketoaldehyde dehydrogenase
NAD+-dependent alpha-ketoaldehyde dehydrogenase
2-oxoaldehyde dehydrogenase (NAD+)

Classification

Oxidoreductases

Acting on the aldehyde or oxo group of donors

With NAD(+) or NADP(+) as acceptor

Catalyses reactions

NAD+ + H2O + 2-Oxoaldehyde <-> NADH + H+ + 2-Oxo acid

NAD+ + H2O + Methylglyoxal <-> Pyruvate + NADH + H+

H2O + NADP+ + Methylglyoxal <-> Pyruvate + H+ + NADPH

NAD+ + H2O + D-Lactaldehyde <-> NADH + H+ + D-Lactate

NAD+ + H2O + Hydroxypyruvaldehyde <-> NADH + H+ + 3-Hydroxypyruvate

H2O + Methylglyoxal + 3-Acetylpyridine-adenine dinucleotide <-> Pyruvate + H+ + Reduced 3-acetylpyridine-adenine dinucleotide

NAD+ + H2O + Phenylglyoxal <-> NADH + H+ + alpha-Oxo-benzeneacetic acid

NAD+ + H2O + Glyoxal <-> NADH + H+ + Glyoxylate

H2O + Methylglyoxal + thio-NAD+ <-> Pyruvate + H+ + thio-NADH

NAD+ + H2O + 2-Keto-3-deoxy-D-glucose <-> NADH + H+ + 2-Keto-3-deoxy-D-gluconate

NAD+ + H2O + 3-Deoxy-D-glucosone <-> NADH + 2-Keto-3-deoxy-D-gluconate

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 1.2.1.23