Enzyme Details

EC Classification

1.2.1.12

Enzyme name
(recommended)

glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)

Alternative names

D-glyceraldehyde-3-phosphate:NAD+ oxidoreductase (phosphorylating)
triosephosphate dehydrogenase
dehydrogenase, glyceraldehyde phosphate
phosphoglyceraldehyde dehydrogenase
3-phosphoglyceraldehyde dehydrogenase
NAD+-dependent glyceraldehyde phosphate dehydrogenase
glyceraldehyde phosphate dehydrogenase (NAD+)
glyceraldehyde-3-phosphate dehydrogenase (NAD+)
NADH-glyceraldehyde phosphate dehydrogenase
glyceraldehyde-3-P-dehydrogenase

Classification

Oxidoreductases

Acting on the aldehyde or oxo group of donors

With NAD(+) or NADP(+) as acceptor

Catalyses reactions

D-Glyceraldehyde 3-phosphate + Phosphate + NAD+ <-> Glycerate 1,3-bisphosphate + NADH + H+

D-Glyceraldehyde 3-phosphate + Phosphate + NADP+ <-> Glycerate 1,3-bisphosphate + H+ + NADPH

H2O + NADP+ + (2R,4S)-2,4-Diaminopentanoate <-> H+ + NADPH + NH3 + 2-Amino-4-oxopentanoate

Phosphate + NAD+ + D-Erythrose 4-phosphate <-> NADH + H+ + 4-Phospho-D-erythronoyl phosphate

Phosphate + NAD+ + D-Glyceraldehyde <-> NADH + H+ + 1-Phospho-D-glycerate

D-Glyceraldehyde 3-phosphate + NAD+ + Arsenate <-> NADH + H+ + 3-Phospho-D-glyceroyl arsenate

D-Glyceraldehyde 3-phosphate + Phosphate + Nicotinamide hypoxanthine dinucleotide <-> Glycerate 1,3-bisphosphate + H+ + Deamino-NADH

D-Glyceraldehyde 3-phosphate + Phosphate + NAD+ <-> NADH + H+ + 3-Phospho-D-glyceroyl phosphate

H+ + NADPH + 3-Phospho-D-glyceroyl phosphate <-> D-Glyceraldehyde 3-phosphate + Phosphate + NADP+

NAD+ + GAPDH <-> Enzyme-NAD complex

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 1.2.1.12