Enzyme Details

EC Classification

1.17.4.2

Enzyme name
(recommended)

ribonucleoside-triphosphate reductase

Alternative names

2'-deoxyribonucleoside-triphosphate:thioredoxin-disulfide 2'-oxidoreductase
ribonucleotide reductase
2'-deoxyribonucleoside-triphosphate:oxidized-thioredoxin 2'-oxidoreductase

Classification

Oxidoreductases

Acting on -CH(2) groups

With a disulfide as acceptor

Catalyses reactions

H2O + Oxidized thioredoxin + Deoxynucleoside triphosphate <-> Reduced thioredoxin + NTP

H2O + Oxidized thioredoxin + dCDP <-> CDP + Reduced thioredoxin

H2O + Oxidized thioredoxin + dCTP <-> CTP + Reduced thioredoxin

H2O + Oxidized thioredoxin + dUTP <-> UTP + Reduced thioredoxin

H2O + dATP + Oxidized thioredoxin <-> ATP + Reduced thioredoxin

H2O + Oxidized thioredoxin + dGTP <-> GTP + Reduced thioredoxin

CTP + Dihydrolipoate <-> H2O + dCTP + Lipoate

CDP + Dihydrolipoate <-> H2O + dCDP + Lipoate

CMP + Dihydrolipoate <-> H2O + dCMP + Lipoate

GTP + Dihydrolipoate <-> H2O + dGTP + Lipoate

ATP + 1,4-Dithiothreitol <-> H2O + dATP + Oxidized dithiothreitol

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 1.17.4.2