Enzyme Details

EC Classification

1.17.3.2

Enzyme name
(recommended)

xanthine oxidase

Alternative names

xanthine:oxygen oxidoreductase
hypoxanthine oxidase
hypoxanthine:oxygen oxidoreductase
Schardinger enzyme
xanthine oxidoreductase
hypoxanthine-xanthine oxidase
xanthine:O2 oxidoreductase
xanthine:xanthine oxidase

Classification

Oxidoreductases

Acting on -CH(2) groups

With oxygen as acceptor

Catalyses reactions

H2O + O2 + Hypoxanthine <-> Xanthine + H2O2

H2O + O2 + Xanthine <-> Urate + H2O2

2 H2O + 2 O2 + 1-Methylnicotinamide <-> 2 H2O2 + N1-Methyl-2-pyridone-5-carboxamide + N1-Methyl-4-pyridone-5-carboxamide

H2O + O2 + Benzaldehyde <-> H2O2 + Benzoate

Xanthine + Nitrite <-> Urate + Nitric oxide

NADH + H+ + Nitrite <-> NAD+ + H2O + Nitric oxide

Nitrite + 2,3-Dihydroxybenzaldehyde <-> 2,3-Dihydroxybenzoate + Nitric oxide

H2O + O2 + Purine nucleoside <-> H2O2 + 7,9-Dihydropurin-8-one ribonucleoside

H2O + O2 + Purine 2'-deoxyribonucleoside <-> H2O2 + 7,9-Dihydropurin-8-one 2'-deoxyribonucleoside

H2O + O2 + 2-Hydroxypurine <-> H2O2 + 2-Hydroxy-7,9-dihydropurin-8-one

H2O + O2 + 2-Aminopurine <-> H2O2 + 2-Amino-7,9-dihydropurin-8-one

H2O + O2 + 2-Aminopurine ribonucleoside <-> H2O2 + 2-Amino-7,9-dihydropurin-8-one ribonucleoside

H2O + O2 + 2-Aminopurine 2'-deoxyribonucleoside <-> H2O2 + 2-Amino-7,9-dihydropurin-8-one 2'-deoxyribonucleoside

H2O + O2 + 2-Aminopurine arabinonucleoside <-> H2O2 + 2-Amino-7,9-dihydropurin-8-one arabinonucleoside

H2O + O2 + 6'-Deoxyacyclovir <-> H2O2 + 6-Deoxy-8-hydroxyacyclovir

H2O + O2 + 6-Methylpurine <-> H2O2 + 6-Methyl-7,9-dihydropurin-8-one

2 H2O + 2 O2 + Hypoxanthine <-> Urate + 2 H2O2

2 H2O + 2 O2 + 3-Methylhypoxanthine <-> 2 H2O2 + 3-Methylurate

2 H2O + 2 O2 + 7-Methylhypoxanthine <-> 2 H2O2 + 7-Methylurate

H2O + O2 + Inosine <-> H2O2 + 8-Hydroxyinosine

H2O + O2 + 6-Methylaminopurine <-> H2O2 + 6-Methylamino-7,9-dihydropurin-8-one

H2O + O2 + Guanosine <-> H2O2 + 8-Hydroxyguanosine

H2O + O2 + Deoxyguanosine <-> H2O2 + 2'-Deoxy-8-hydroxyguanosine

H2O + Adenine + O2 <-> H2O2 + 6-Amino-7,9-dihydropurin-8-one

H2O + O2 + Allopurinol <-> H2O2 + Alloxanthine

H2O + O2 + Formycin B <-> H2O2 + Oxoformycin B

H2O + O2 + Purine <-> H2O2 + 7,9-Dihydropurin-8-one

H2O + O2 + 6-Mercaptopurine <-> H2O2 + 6-Sulfanylidene-7,9-dihydro-3H-purin-8-one

NAD+ + H2O + all-trans-Retinal <-> NADH + H+ + Retinoate

H2O + O2 + 6-Deoxypenciclovir <-> H2O2 + Penciclovir

External links

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