Enzyme Details

 EC Classification 1.14.99.1
 Enzyme name
(recommended)
prostaglandin-endoperoxide synthase
 Alternative names (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate,hydrogen-donor:oxygen oxidoreductase
prostaglandin synthase
prostaglandin G/H synthase
(PG)H synthase
PG synthetase
prostaglandin synthetase
fatty acid cyclooxygenase
prostaglandin endoperoxide synthetase
 Classification
Oxidoreductases
Acting on paired donors with incorporation of molecular oxygen
Miscellaneous (requires further characterization)
 Catalyses reactions
O2 + 2 Prostaglandin H2 <-> 2 Prostaglandin G2
2 O2 + Arachidonate <-> Prostaglandin G2
2 O2 + Arachidonate + Reduced acceptor <-> H2O + Acceptor + Prostaglandin H2
Guaiacol + 5-Hydroperoxypent-1-enylbenzene <-> Reduced 5-hydroperoxypent-1-enylbenzene + Oxidized guaiacol
2 Guaiacol + 15-HPETE <-> H2O + 15-HETE + 3,3'-Dimethoxydipheno-4,4'-quinone
2 Guaiacol + Ethyl hydroperoxide <-> H2O + Ethanol + 3,3'-Dimethoxydipheno-4,4'-quinone
H2O2 + 2 Guaiacol <-> H2O + 3,3'-Dimethoxydipheno-4,4'-quinone
Guaiacol + t-Butylhydroperoxide <-> H2O + t-Butanol + 3,3'-Dimethoxydipheno-4,4'-quinone
2 Guaiacol + trans-5-Phenyl-4-pentenyl hydroperoxide <-> H2O + 3,3'-Dimethoxydipheno-4,4'-quinone + 5-Phenyl-4E-pentenol
2 O2 + alpha-Linolenate + Reduced acceptor <-> Unknown + H2O + Acceptor
2 O2 + Reduced acceptor + Dihomolinoleate <-> Unknown + H2O + Acceptor
2 O2 + gamma-Linolenic acid + Reduced acceptor <-> Unknown + H2O + Acceptor
2 O2 + Reduced acceptor + 8,11,14-Eicosatrienoate <-> Unknown + H2O + Acceptor
2 O2 + Eicosapentaenoic acid + Reduced acceptor <-> Unknown + H2O + Acceptor
2 O2 + Reduced acceptor + Docosatetraenoic acid <-> Unknown + H2O + Acceptor
2 O2 + Docosahexaenoic acid + Reduced acceptor <-> Unknown + H2O + Acceptor
 External links Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop


View all entries for EC Class: 1.14.99.1



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