Enzyme Details

EC Classification

1.14.99.1

Enzyme name
(recommended)

prostaglandin-endoperoxide synthase

Alternative names

(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate,hydrogen-donor:oxygen oxidoreductase
prostaglandin synthase
prostaglandin G/H synthase
(PG)H synthase
PG synthetase
prostaglandin synthetase
fatty acid cyclooxygenase
prostaglandin endoperoxide synthetase

Classification

Oxidoreductases

Acting on paired donors with incorporation of molecular oxygen

Miscellaneous (requires further characterization)

Catalyses reactions

O2 + 2 Prostaglandin H2 <-> 2 Prostaglandin G2

2 O2 + Arachidonate <-> Prostaglandin G2

2 O2 + Arachidonate + Reduced acceptor <-> H2O + Acceptor + Prostaglandin H2

Guaiacol + 5-Hydroperoxypent-1-enylbenzene <-> Reduced 5-hydroperoxypent-1-enylbenzene + Oxidized guaiacol

2 Guaiacol + 15-HPETE <-> H2O + 15-HETE + 3,3'-Dimethoxydipheno-4,4'-quinone

2 Guaiacol + Ethyl hydroperoxide <-> H2O + Ethanol + 3,3'-Dimethoxydipheno-4,4'-quinone

H2O2 + 2 Guaiacol <-> H2O + 3,3'-Dimethoxydipheno-4,4'-quinone

Guaiacol + t-Butylhydroperoxide <-> H2O + t-Butanol + 3,3'-Dimethoxydipheno-4,4'-quinone

2 Guaiacol + trans-5-Phenyl-4-pentenyl hydroperoxide <-> H2O + 3,3'-Dimethoxydipheno-4,4'-quinone + 5-Phenyl-4E-pentenol

2 O2 + alpha-Linolenate + Reduced acceptor <-> Unknown + H2O + Acceptor

2 O2 + Reduced acceptor + Dihomolinoleate <-> Unknown + H2O + Acceptor

2 O2 + gamma-Linolenic acid + Reduced acceptor <-> Unknown + H2O + Acceptor

2 O2 + Reduced acceptor + 8,11,14-Eicosatrienoate <-> Unknown + H2O + Acceptor

2 O2 + Eicosapentaenoic acid + Reduced acceptor <-> Unknown + H2O + Acceptor

2 O2 + Reduced acceptor + Docosatetraenoic acid <-> Unknown + H2O + Acceptor

2 O2 + Docosahexaenoic acid + Reduced acceptor <-> Unknown + H2O + Acceptor

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 1.14.99.1