Enzyme Details

EC Classification

1.14.18.1

Enzyme name
(recommended)

monophenol monooxygenase

Alternative names

cresolase
catechol oxidase
polyphenolase
phenolase
catecholase
monophenol,L-dopa:oxygen oxidoreductase
tyrosinase
monophenol oxidase
pyrocatechol oxidase
dopa oxidase
chlorogenic oxidase
polyphenol oxidase
monophenolase
o-diphenol oxidase
chlorogenic acid oxidase
diphenol oxidase
o-diphenolase
tyrosine-dopa oxidase
o-diphenol:oxygen oxidoreductase
polyaromatic oxidase
monophenol monooxidase
o-diphenol oxidoreductase
monophenol dihydroxyphenylalanine:oxygen oxidoreductase
N-acetyl-6-hydroxytryptophan oxidase
monophenol, dihydroxy-L-phenylalanine oxygen oxidoreductase
o-diphenol:O2 oxidoreductase
phenol oxidase

Classification

Oxidoreductases

Acting on paired donors with incorporation of molecular oxygen

With another compound as one donor, and incorporation of one atom of oxygen

Catalyses reactions

2 H2O2 <-> 2 H2O + O2

O2 + 2 L-Dopa <-> 2 H2O + 2 Dopaquinone

L-Tyrosine + O2 <-> H2O + L-Dopa

L-Tyrosine + O2 + L-Dopa <-> H2O + L-Dopa + Dopaquinone

O2 + 2 Hydroquinone <-> 2 H2O + 2 1,4-Benzoquinone

NADH + H+ + O2 + Tyramine <-> NAD+ + H2O + Dopamine

O2 + 4-Coumarate <-> H2O + 3,4-Dihydroxy-trans-cinnamate

L-Dopachrome <-> CO2 + 5,6-Dihydroxyindole

O2 + (S)-N-Methylcoclaurine <-> H2O + 3'-Hydroxy-N-methyl-(S)-coclaurine

O2 + 2 5,6-Dihydroxyindole <-> 2 H2O + 2 Indole-5,6-quinone

H2O2 + 4-Chlorophenol <-> H2O + 4-Chlorocatechol

H2O2 + 4-Cresol <-> H2O + 4-Methylcatechol

H2O2 + Methylparaben <-> H2O + Methyl 3,4-dihydroxybenzoate

H2O2 + p-Bromophenol <-> H2O + 4-Bromocatechol

H2O2 + p-Fluorophenol <-> H2O + 4-Fluorocatechol

O2 + (+)-Catechin <-> H2O + Catechin-O-quinone

O2 + L-Dopa <-> H2O + L-Dopachrome

O2 + Quercetin <-> H2O + Quercetin o-quinone

O2 + 4-(tert-Butyl)benzo-1,2-quinone + 4-tert-Butylcatechol <-> 2 H2O

O2 + L-Noradrenaline <-> H2O2 + L-Noradrenalinequinone

O2 + L-Dopa <-> H2O2 + L-Dopaquinone

O2 + L-Adrenaline <-> H2O2 + L-Adrenalinequinone

O2 + 2 D-Dopa <-> 2 H2O + 2 D-Dopaquinone

O2 + 2 L-Dopa <-> 2 H2O + 2 L-Dopaquinone

O2 + 2 L-Noradrenaline <-> 2 H2O + 2 L-Noradrenalinequinone

O2 + D-Dopa <-> H2O2 + D-Dopaquinone

O2 + 2 L-Adrenaline <-> 2 H2O + 2 L-Adrenalinequinone

O2 + Dopaxanthin <-> 2 H2O + Dipicolinic acid

O2 + Dopaxanthin <-> 2 H2O + Dopaxanthinquinone

O2 + Acetaminophen <-> H2O + 4-Acetamido-o-benzoquinone

O2 + 2 Catechol <-> 2 H2O + 2 1,2-Benzoquinone

O2 + 2 4-Methylcatechol <-> 2 H2O + 2 4-Methyl-o-benzoquinone

O2 + 2 4-tert-Butylcatechol <-> 2 H2O + 2 4-tert-Butyl-o-benzoquinone

O2 + 2 3,4-Dihydroxyphenylacetate <-> 2 H2O + 2 2-(3,4-Dioxocyclohexa-1,5-dien-1-yl)acetic acid

O2 + 2 3,4-Dihydroxyphenyl propionic acid <-> 2 H2O + 2 2-(3,4-Dioxocyclohexa-1,5-dien-1-yl)propionic acid

O2 + 2 Dopamine <-> 2 H2O + 2 Dopamine quinone

O2 + 2 L-alpha-Methyldopa <-> 2 H2O + 2 L-alpha-Methyldopaquinone

O2 + 2 Dopa methyl ester <-> 2 H2O + 2 Dopaquinone methyl ester

O2 + 2 Levisoprenaline <-> 2 H2O + 2 1-[1-Hydroxy-2-(propan-2-ylamino)ethyl]-3,4-dioxocyclohexa-1,5-diene

O2 + 4-Hydroxyanisole <-> H2O + 3-Methoxycatechol

O2 + 4-Ethoxyphenol <-> H2O + 3-Ethoxycatechol

O2 + 4-Hydroxyphenyl propionic acid <-> H2O + 3,4-Dihydroxyphenyl propionic acid

O2 + 4-Hydroxyphenylacetate <-> H2O + 3,4-Dihydroxyphenylacetate

O2 + Tyramine <-> H2O + Dopamine

O2 + Phenol <-> H2O + Catechol

O2 + L-alpha-Methyltyrosine <-> H2O + L-alpha-Methyldopa

2 L-Tyrosine + O2 <-> 2 L-Dopa

L-Tyrosine + O2 <-> H2O + Dopaquinone

L-Tyrosine + O2 <-> H2O + L-Dopaquinone

O2 + D-Tyrosine <-> H2O + D-Dopaquinone

O2 + 4-Cresol <-> H2O + 4-Methylcatechol

O2 + 4-tert-Butylphenol <-> H2O + 4-tert-Butylcatechol

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

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