Enzyme Details

 EC Classification 1.14.18.1
 Enzyme name
(recommended)
monophenol monooxygenase
 Alternative names cresolase
catechol oxidase
polyphenolase
phenolase
catecholase
monophenol,L-dopa:oxygen oxidoreductase
tyrosinase
monophenol oxidase
pyrocatechol oxidase
dopa oxidase
chlorogenic oxidase
polyphenol oxidase
monophenolase
o-diphenol oxidase
chlorogenic acid oxidase
diphenol oxidase
o-diphenolase
tyrosine-dopa oxidase
o-diphenol:oxygen oxidoreductase
polyaromatic oxidase
monophenol monooxidase
o-diphenol oxidoreductase
monophenol dihydroxyphenylalanine:oxygen oxidoreductase
N-acetyl-6-hydroxytryptophan oxidase
monophenol, dihydroxy-L-phenylalanine oxygen oxidoreductase
o-diphenol:O2 oxidoreductase
phenol oxidase
 Classification
Oxidoreductases
Acting on paired donors with incorporation of molecular oxygen
With another compound as one donor, and incorporation of one atom of oxygen
 Catalyses reactions
2 H2O2 <-> 2 H2O + O2
O2 + 2 L-Dopa <-> 2 H2O + 2 Dopaquinone
L-Tyrosine + O2 <-> H2O + L-Dopa
L-Tyrosine + O2 + L-Dopa <-> H2O + L-Dopa + Dopaquinone
O2 + 2 Hydroquinone <-> 2 H2O + 2 1,4-Benzoquinone
NADH + H+ + O2 + Tyramine <-> NAD+ + H2O + Dopamine
O2 + 4-Coumarate <-> H2O + 3,4-Dihydroxy-trans-cinnamate
L-Dopachrome <-> CO2 + 5,6-Dihydroxyindole
O2 + (S)-N-Methylcoclaurine <-> H2O + 3'-Hydroxy-N-methyl-(S)-coclaurine
O2 + 2 5,6-Dihydroxyindole <-> 2 H2O + 2 Indole-5,6-quinone
H2O2 + 4-Chlorophenol <-> H2O + 4-Chlorocatechol
H2O2 + 4-Cresol <-> H2O + 4-Methylcatechol
H2O2 + Methylparaben <-> H2O + Methyl 3,4-dihydroxybenzoate
H2O2 + p-Bromophenol <-> H2O + 4-Bromocatechol
H2O2 + p-Fluorophenol <-> H2O + 4-Fluorocatechol
O2 + (+)-Catechin <-> H2O + Catechin-O-quinone
O2 + L-Dopa <-> H2O + L-Dopachrome
O2 + Quercetin <-> H2O + Quercetin o-quinone
O2 + 4-(tert-Butyl)benzo-1,2-quinone + 4-tert-Butylcatechol <-> 2 H2O
O2 + L-Noradrenaline <-> H2O2 + L-Noradrenalinequinone
O2 + L-Dopa <-> H2O2 + L-Dopaquinone
O2 + L-Adrenaline <-> H2O2 + L-Adrenalinequinone
O2 + 2 D-Dopa <-> 2 H2O + 2 D-Dopaquinone
O2 + 2 L-Dopa <-> 2 H2O + 2 L-Dopaquinone
O2 + 2 L-Noradrenaline <-> 2 H2O + 2 L-Noradrenalinequinone
O2 + D-Dopa <-> H2O2 + D-Dopaquinone
O2 + 2 L-Adrenaline <-> 2 H2O + 2 L-Adrenalinequinone
O2 + Dopaxanthin <-> 2 H2O + Dipicolinic acid
O2 + Dopaxanthin <-> 2 H2O + Dopaxanthinquinone
O2 + Acetaminophen <-> H2O + 4-Acetamido-o-benzoquinone
O2 + 2 Catechol <-> 2 H2O + 2 1,2-Benzoquinone
O2 + 2 4-Methylcatechol <-> 2 H2O + 2 4-Methyl-o-benzoquinone
O2 + 2 4-tert-Butylcatechol <-> 2 H2O + 2 4-tert-Butyl-o-benzoquinone
O2 + 2 3,4-Dihydroxyphenylacetate <-> 2 H2O + 2 2-(3,4-Dioxocyclohexa-1,5-dien-1-yl)acetic acid
O2 + 2 3,4-Dihydroxyphenyl propionic acid <-> 2 H2O + 2 2-(3,4-Dioxocyclohexa-1,5-dien-1-yl)propionic acid
O2 + 2 Dopamine <-> 2 H2O + 2 Dopamine quinone
O2 + 2 L-alpha-Methyldopa <-> 2 H2O + 2 L-alpha-Methyldopaquinone
O2 + 2 Dopa methyl ester <-> 2 H2O + 2 Dopaquinone methyl ester
O2 + 2 L-Isoproterenol <-> 2 H2O + 2 1-[1-Hydroxy-2-(propan-2-ylamino)ethyl]-3,4-dioxocyclohexa-1,5-diene
O2 + 4-Hydroxyanisole <-> H2O + 3-Methoxycatechol
O2 + 4-Ethoxyphenol <-> H2O + 3-Ethoxycatechol
O2 + 4-Hydroxyphenyl propionic acid <-> H2O + 3,4-Dihydroxyphenyl propionic acid
O2 + 4-Hydroxyphenylacetate <-> H2O + 3,4-Dihydroxyphenylacetate
O2 + Tyramine <-> H2O + Dopamine
O2 + Phenol <-> H2O + Catechol
O2 + L-alpha-Methyltyrosine <-> H2O + L-alpha-Methyldopa
2 L-Tyrosine + O2 <-> 2 L-Dopa
L-Tyrosine + O2 <-> H2O + Dopaquinone
L-Tyrosine + O2 <-> H2O + L-Dopaquinone
O2 + D-Tyrosine <-> H2O + D-Dopaquinone
 External links Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop


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