Enzyme Details

EC Classification

1.14.17.1

Enzyme name
(recommended)

dopamine beta-monooxygenase

Alternative names

3,4-dihydroxyphenethylamine,ascorbate:oxygen oxidoreductase (beta-hydroxylating)
dopamine beta-hydroxylase
MDBH (membrane-associated dopamine beta-monooxygenase)
SDBH (soluble dopamine beta-monooxygenase)
dopamine-B-hydroxylase
oxygenase, dopamine beta-mono-
3,4-dihydroxyphenethylamine beta-oxidase
4-(2-aminoethyl)pyrocatechol beta-oxidase
dopa beta-hydroxylase
dopamine beta-oxidase
dopamine hydroxylase
phenylamine beta-hydroxylase
(3,4-dihydroxyphenethylamine)beta-mono-oxygenase
DbetaM

Classification

Oxidoreductases

Acting on paired donors with incorporation of molecular oxygen

With ascorbate as one donor, and incorporation of one atom of oxygen

Catalyses reactions

O2 + L-Ascorbate + Dopamine <-> H2O + L-Noradrenaline + Dehydroascorbate

O2 + Tyramine + N-(4-Chlorophenyl)-N'-hydroxyguanidine <-> H2O + 1-(4-Hydroxyphenyl)-2-aminoethanol + N-(4-Chlorophenyl)-N'-nitrosoimine

O2 + Tyramine + N-(4-Methoxyphenyl)-N'-hydroxyguanidine <-> H2O + 1-(4-Hydroxyphenyl)-2-aminoethanol + N-(4-Methoxyphenyl)-N'-nitrosoimine

O2 + L-Ascorbate + 4-(Trifluoromethyl)phenethylamine <-> H2O + Dehydroascorbate + 4-(Trifluoromethyl)phenylethanolamine

O2 + L-Ascorbate + 2-Phenylethylamine <-> H2O + Phenylethanolamine + Dehydroascorbate

O2 + L-Ascorbate + Tyramine <-> H2O + Dehydroascorbate + 1-(4-Hydroxyphenyl)-2-aminoethanol

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 1.14.17.1