Enzyme Details

EC Classification

1.14.15.18

Enzyme name
(recommended)

calcidiol 1-monooxygenase

Alternative names

calcidiol,adrenodoxin:oxygen oxidoreductase (1-hydroxylating)
25-hydroxycholecalciferol 1-hydroxylase
25-hydroxycholecalciferol 1?-hydroxylase
25-hydroxyvitamin D3 1?-hydroxylase
25-hydroxycholecalciferol 1-monooxygenase
1-hydroxylase-25-hydroxyvitamin D3
25-hydroxy D3-1?-hydroxylase
calcidiol,NADPH:oxygen oxidoreductase (1-hydroxylating)
25-hydroxycholecalciferol 1-hydroxylase
25-hydroxycholecalciferol 1-monooxygenase
1-hydroxylase-25-hydroxyvitamin D3
25-hydroxy D3-1alpha-hydroxylase
25-hydroxycholecalciferol 1alpha-hydroxylase
25-hydroxyvitamin D3 1alpha-hydroxylase

Classification

Oxidoreductases

Acting on paired donors with incorporation of molecular oxygen

With a reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen

Catalyses reactions

H+ + NADPH + O2 + Calcidiol <-> H2O + NADP+ + Calcitriol

H+ + NADPH + O2 + Secalciferol <-> H2O + NADP+ + Calcitetrol

H+ + NADPH + O2 + 23S,25-Dihydroxyvitamin D3 <-> H2O + NADP+ + 1alpha,23S,25-Trihydroxyvitamin D3

H+ + NADPH + O2 + 24-Oxo-25-hydroxyvitamin D3 <-> H2O + NADP+ + 1alpha,25-Dihydroxy-24-oxovitamin D3

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 1.14.15.18