Enzyme Details

EC Classification

1.14.14.94

Enzyme name
(recommended)

leukotriene-B4 20-monooxygenase

Alternative names

(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate,NADPH:oxygen oxidoreductase (20-hydroxylating)
leukotriene-B4 20-hydroxylase
leucotriene-B4 omega-hydroxylase
LTB4 20-hydroxylase
LTB4 omega-hydroxylase

Classification

Oxidoreductases

Acting on paired donors with incorporation of molecular oxygen

With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

Catalyses reactions

H+ + NADPH + O2 + Leukotriene B4 <-> H2O + NADP+ + 20-OH-Leukotriene B4

NADH + H+ + O2 + Leukotriene B4 <-> NAD+ + H2O + 19-OH-Leukotriene B4

NADH + H+ + O2 + Leukotriene B4 <-> NAD+ + H2O + 20-OH-Leukotriene B4

H+ + NADPH + O2 + Leukotriene B4 <-> H2O + NADP+ + 19-OH-Leukotriene B4

H+ + NADPH + O2 + 20-CHO-Leukotriene B4 <-> H2O + NADP+ + 20-COOH-Leukotriene B4

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 1.14.14.94