Enzyme Details

 EC Classification 1.14.14.91
 Enzyme name
(recommended)
trans-cinnamate 4-monooxygenase
 Alternative names trans-cinnamate,NADPH:oxygen oxidoreductase (4-hydroxylating)
cinnamic acid 4-hydroxylase
oxygenase, cinnamate 4-mono-
CA4H
cytochrome P450 cinnamate 4-hydroxylase
cinnamate 4-hydroxylase
cinnamate 4-monooxygenase
cinnamate hydroxylase
cinnamic 4-hydroxylase
cinnamic acid 4-monooxygenase
cinnamic acid p-hydroxylase
hydroxylase, cinnamate 4-
t-cinnamic acid hydroxylase
trans-cinnamate 4-hydroxylase
trans-cinnamic acid 4-hydroxylase
 Classification
Oxidoreductases
Acting on paired donors with incorporation of molecular oxygen
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
 Catalyses reactions
H+ + NADPH + O2 + trans-Cinnamate <-> H2O + NADP+ + 4-Coumarate
H+ + NADPH + O2 + trans-Cinnamate <-> H2O + NADP+ + 2-Hydroxycinnamate
H+ + NADPH + O2 + 2-Fluoro-trans-cinnamate <-> H2O + NADP+ + 2-Fluoro-4-hydroxycinnamate
H+ + NADPH + O2 + 2-Chloro-trans-cinnamate <-> H2O + NADP+ + 2-Chloro-4-hydroxycinnamate
H+ + NADPH + O2 + 3-Hydroxycinnamate <-> H2O + NADP+ + Caffeate
H+ + NADPH + O2 + 2-Methylcinnamate <-> H2O + NADP+ + 2-Methyl-4-hydroxycinnamate
H+ + NADPH + O2 + 2-Ethoxycinnamate <-> H2O + NADP+ + 2-Ethoxy-4-hydroxycinnamate
H+ + NADPH + O2 + 2-Methoxycinnamate <-> H2O + NADP+ + 2-Methoxy-4-hydroxycinnamate
H+ + NADPH + O2 + 2-Nitrocinnamate <-> H2O + NADP+ + 2-Nitro-4-hydroxycinnamate
 External links Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop


View all entries for EC Class: 1.14.14.91



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