Enzyme Details

 EC Classification 1.14.14.18
 Enzyme name
(recommended)
heme oxygenase
 Alternative names heme,hydrogen-donor:oxygen oxidoreductase (alpha-methene-oxidizing, hydroxylating)
ORP33 proteins
haem oxygenase
heme oxygenase (decyclizing)
heme oxidase
haem oxidase
 Classification
Oxidoreductases
Acting on paired donors with incorporation of molecular oxygen
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
 Catalyses reactions
3 O2 + 3 Reduced acceptor + Heme <-> 3 H2O + Fe2+ + Carbon monoxide + 3 Acceptor + Biliverdin
3 O2 + FADH2 + Hemoglobin <-> 3 H2O + FAD + Fe2+ + Carbon monoxide + Biliverdin + Globin
3 NADPH + 3 O2 + Heme <-> 3 H2O + 3 NADP+ + Fe2+ + Carbon monoxide + Biliverdin
3 NADPH + 3 O2 + Heme c <-> 3 H2O + 3 NADP+ + Fe2+ + Carbon monoxide + Biliverdin c
3 NADPH + 3 O2 + Hematoheme <-> 3 H2O + 3 NADP+ + Fe2+ + Carbon monoxide + Hematobiliverdin
3 NADPH + 3 O2 + Hematin <-> 3 H2O + 3 NADP+ + Fe2+ + Carbon monoxide + Biliverdin
3 NADH + 3 O2 + Heme <-> 3 NAD+ + 3 H2O + Fe2+ + Carbon monoxide + Biliverdin
 External links Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop


View all entries for EC Class: 1.14.14.18



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