Enzyme Details

EC Classification

1.14.14.18

Enzyme name
(recommended)

heme oxygenase

Alternative names

heme oxidase
haem oxidase
heme,hydrogen-donor:oxygen oxidoreductase (alpha-methene-oxidizing, hydroxylating)
ORP33 proteins
haem oxygenase
heme oxygenase (decyclizing)

Classification

Oxidoreductases

Acting on paired donors with incorporation of molecular oxygen

With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

Catalyses reactions

3 O2 + 3 Reduced acceptor + Heme <-> 3 H2O + Fe2+ + Carbon monoxide + 3 Acceptor + Biliverdin

3 O2 + FADH2 + Hemoglobin <-> 3 H2O + FAD + Fe2+ + Carbon monoxide + Biliverdin + Globin

3 NADPH + 3 O2 + Heme <-> 3 H2O + 3 NADP+ + Fe2+ + Carbon monoxide + Biliverdin

3 NADPH + 3 O2 + Heme c <-> 3 H2O + 3 NADP+ + Fe2+ + Carbon monoxide + Biliverdin c

3 NADPH + 3 O2 + Hematoheme <-> 3 H2O + 3 NADP+ + Fe2+ + Carbon monoxide + Hematobiliverdin

3 NADPH + 3 O2 + Hematin <-> 3 H2O + 3 NADP+ + Fe2+ + Carbon monoxide + Biliverdin

3 NADH + 3 O2 + Heme <-> 3 NAD+ + 3 H2O + Fe2+ + Carbon monoxide + Biliverdin

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 1.14.14.18